In vivo diffusion tensor imaging of amyloid‐β‐induced white matter damage in mice
Open accessAbstract
BACKGROUND: Diffusion tensor imaging (DTI) suggests the presence of white matter abnormality at the prodromal stage in human Alzheimer's disease (AD). OBJECTIVE: To use a mouse model of AD to determine whether the white matter abnormality detected by in vivo DTI is associated with functional deficits and axon damage. METHODS: Amyloid-β1-42 (Aβ1-42) was injected into the left lateral ventricle in mice. Two months after the injection, in vivo DTI and visual evoked potential (VEP) recordings were performed, followed by immunohistochemistry of phosphorylated neurofilament and myelin basic protein. RESULTS: DTI of Aβ1-42-treated mice showed a significant increase of radial diffusivity in white matter including the optic nerves and tracts. The abnormality was associated with decreased amplitude and increased latency of VEP. Immunohistochemistry confirmed a significant loss of axons and myelin integrity. CONCLUSION: White matter damage induced by Aβ1-42 in mice can be detected non-invasively by DTI.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Significant directional alignment between MRI and transcriptional changes likely reflects co-occurring neuronal loss, dendritic degeneration, axonal disruption, and myelin damage, together with cellular responses to neuroinflammation and neuropathology.
“Significant directional alignment between MRI and transcriptional changes likely reflects co‐occurring neuronal loss, dendritic degeneration, axonal disruption, and myelin damage, 85 , 86 , 87 together with cellular responses to neuroinflammation and neuropathology. 69”
From Diffusion MRI reveals amyloid plaque–associated cellular signatures through spatial transcriptomic integration (2026) · cites this paper as [87]
The Results and Discussion report that DTI abnormalities in Aβ-treated mice were associated with axonal loss and myelin damage. They do not establish neuronal loss or dendritic degeneration, and the study did not compare MRI with transcriptional changes. The separate claim about cellular responses is attached to citation 69, not this source. (LLM, conf=0.84)
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
Li, J., Wang, C., Zhang, J. H., Cai, J., Cao, Y., & Sun, X. (2010) · Brain Research · doi:10.1016/j.brainres.2010.02.046 · Cited by 204 · see citing works
RetractedThe Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859 · see citing works
Alzheimer's Disease: Genes, Proteins, and Therapy
Selkoe, D. J. (2001) · Physiological Reviews · doi:10.1152/physrev.2001.81.2.741 · Cited by 6,063 · see citing works
Diffusion tensor MR imaging of the human brain
Pierpaoli, C., Jezzard, P., Basser, P. J., Barnett, A., & Di Chiro, G. (1996) · Radiology · doi:10.1148/radiology.201.3.8939209 · Cited by 2,664 · see citing works
Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water
Song, S.-K., Sun, S.-W., Ramsbottom, M. J., Chang, C., Russell, J., & Cross, A. H. (2002) · NeuroImage · doi:10.1006/nimg.2002.1267 · Cited by 2,582 · see citing works
Self-citationAlzheimer's disease: cell-specific pathology isolates the hippocampal formation.
Hyman, B. T., Van Hoesen, G. W., Damasio, A. R., & Barnes, C. L. (1984) · Science · doi:10.1126/science.6474172 · Cited by 2,268 · see citing works
Alzheimer Mechanisms and Therapeutic Strategies
Huang, Y., & Mucke, L. (2012) · Cell · doi:10.1016/j.cell.2012.02.040 · Cited by 1,758 · see citing works
Song, S.-K., Sun, S.-W., Ju, W.-K., Lin, S.-J., Cross, A. H., & Neufeld, A. H. (2003) · NeuroImage · doi:10.1016/j.neuroimage.2003.07.005 · Cited by 1,738 · see citing works
Self-citationAmyloid-β–induced neuronal dysfunction in Alzheimer's disease: from synapses toward neural networks
Palop, J. J., & Mucke, L. (2010) · Nature Neuroscience · doi:10.1038/nn.2583 · Cited by 1,651 · see citing works
Diffusion tensor imaging (DTI)-based white matter mapping in brain research: a review
Assaf, Y., & Pasternak, O. (2008) · Journal of Molecular Neuroscience · doi:10.1007/s12031-007-0029-0 · Cited by 1,537 · see citing works
Verret, L., Mann, E. O., Hang, G. B., Barth, A. M. I., Cobos, I., Ho, K., Devidze, N., Masliah, E., Kreitzer, A. C., Mody, I., et al. (2012) · Cell · doi:10.1016/j.cell.2012.02.046 · Cited by 1,216 · see citing works
A white matter disorder in dementia of the Alzheimer type: A pathoanatomical study
Brun, A., & Englund, E. (1986) · Annals of Neurology · doi:10.1002/ana.410190306 · Cited by 1,014 · see citing works
Mechanisms of Neuronal Degeneration in Alzheimer's Disease
Yankner, B. A. (1996) · Neuron · doi:10.1016/s0896-6273(00)80115-4 · Cited by 947 · see citing works
β-Amyloid fibrils induce tau phosphorylation and loss of microtubule binding
Busciglio, J., Lorenzo, A., Yeh, J., & Yankner, B. A. (1995) · Neuron · doi:10.1016/0896-6273(95)90232-5 · Cited by 595 · see citing works
Douaud, G., Jbabdi, S., Behrens, T. E. J., Menke, R. A., Gass, A., Monsch, A. U., Rao, A., Whitcher, B., Kindlmann, G., Matthews, P. M., et al. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.12.008 · Cited by 514 · see citing works
Sun, S., Liang, H., Trinkaus, K., Cross, A. H., Armstrong, R. C., & Song, S. (2006) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20774 · Cited by 461 · see citing works
Self-citationMucke, L. (2009) · Nature · doi:10.1038/461895a · Cited by 456 · see citing works
A meta-analysis of diffusion tensor imaging in mild cognitive impairment and Alzheimer's disease
Sexton, C. E., Kalu, U. G., Filippini, N., Mackay, C. E., & Ebmeier, K. P. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.05.019 · Cited by 410 · see citing works
İşeri, P., Altıntaş, Ö., Tokay, T., & Yüksel, N. (2006) · Journal of Neuro-Ophthalmology · doi:10.1097/01.wno.0000204645.56873.26 · Cited by 400 · see citing works
Identification of MCI individuals using structural and functional connectivity networks
Chong-yaw Wee, A., Yap, P., Zhang, D., Denny, K., Browndyke, J. N., Potter, G. G., Welsh-Bohmer, K. A., Wang, L., & Shen, D. G. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.10.015 · Cited by 378 · see citing works
White matter damage in frontotemporal dementia and Alzheimer's disease measured by diffusion MRI
Zhang, Y., Schuff, N., Du, A.-T., Rosen, H. J., Kramer, J. H., Gorno-Tempini, M. L., Miller, B. L., & Weiner, M. W. (2009) · Brain · doi:10.1093/brain/awp071 · Cited by 356 · see citing works
Fellgiebel, A., Wille, P., Müller, M. J., Winterer, G., Scheurich, A., Vucurevic, G., Schmidt, L. G., & Stoeter, P. (2004) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000077817 · Cited by 298 · see citing works
Takashima, A., Honda, T., Yasutake, K., Michel, G., Murayama, O., Murayama, M., Ishiguro, K., & Yamaguchi, H. (1998) · Neuroscience Research · doi:10.1016/s0168-0102(98)00061-3 · Cited by 287 · see citing works
Lee, J.-T., Xu, J., Lee, J.-M., Ku, G., Han, X., Yang, D.-I., Chen, S., & Hsu, C. Y. (2004) · The Journal of Cell Biology · doi:10.1083/jcb.200307017 · Cited by 280 · see citing works
White matter pathology isolates the hippocampal formation in Alzheimer's disease
Salat, D. H., Tuch, D. S., van der Kouwe, A. J. W., Greve, D. N., Pappu, V., Lee, S. Y., Hevelone, N. D., Zaleta, A. K., Growdon, J. H., Corkin, S., et al. (2010) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.03.013 · Cited by 279 · see citing works
Effects of injected Alzheimer beta-amyloid cores in rat brain.
Frautschy, S. A., Baird, A., & Cole, G. M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.19.8362 · Cited by 254 · see citing works
Amyloid-β Peptides Are Cytotoxic to Oligodendrocytes
Xu, J., Chen, S., Ahmed, S. H., Chen, H., Ku, G., Goldberg, M. P., & Hsu, C. Y. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-01-j0001.2001 · Cited by 230 · see citing works
The visual physiology of the wild type mouse determined with pattern VEPs
Porciatti, V., Pizzorusso, T., & Maffei, L. (1999) · Vision Research · doi:10.1016/s0042-6989(99)00022-x · Cited by 202 · see citing works
Sun, S., Liang, H., Cross, A. H., & Song, S. (2008) · NeuroImage · doi:10.1016/j.neuroimage.2007.11.049 · Cited by 200 · see citing works
Self-citationJhoo, J. H., Kim, H., Nabeshima, T., Yamada, K., Shin, E., Jhoo, W., Kim, W. K., Kang, K., Jo, S. A., & Woo, J. I. (2004) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.04.012 · Cited by 184 · see citing works
Song, S.-K., Kim, J. H., Lin, S.-J., Brendza, R. P., & Holtzman, D. M. (2004) · Neurobiology of Disease · doi:10.1016/j.nbd.2003.12.003 · Cited by 170 · see citing works
Ashtari, M., Cottone, J. G., Ardekani, B. A., Cervellione, K. L., Szeszko, P. R., Wu, J., Chen, S., & Kumra, S. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.11.1270 · Cited by 170 · see citing works
Flood, J. F., Morley, J. E., & Roberts, E. R. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.8.3363 · Cited by 164 · see citing works
Axonal transport, tau protein, and neurodegeneration in Alzheimer's disease
Terwel, D., Dewachter, I., & Van Leuven, F. (2002) · NeuroMolecular Medicine · doi:10.1385/nmm:2:2:151 · Cited by 146 · see citing works
Jones, D. K., & Pierpaoli, C. M. (2005) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20466 · Cited by 138 · see citing works
DTI analyses and clinical applications in Alzheimer’s disease
Oishi, K., Mielke, M. M., Albert, M., Lyketsos, C. G., & Mori, S. (2011) · Journal of Alzheimer's Disease · doi:10.3233/jad-2011-0007 · Cited by 134 · see citing works
Clerx, L., Visser, P. J., Verhey, F., & Aalten, P. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-110797 · Cited by 132 · see citing works
Sun, S.-W., Song, S.-K., Harms, M. P., Lin, S.-J., Holtzman, D. M., Merchant, K. M., & Kotyk, J. J. (2005) · Experimental Neurology · doi:10.1016/j.expneurol.2004.09.006 · Cited by 121 · see citing works
Self-citationRetinal pathology as biomarker for cognitive impairment and Alzheimer's disease
Ikram, M. K., Cheung, C. Y.-L., Wong, T. Y., & Chen, C. (2012) · Journal of Neurology Neurosurgery & Psychiatry · doi:10.1136/jnnp-2011-301628 · Cited by 119 · see citing works
O'Dwyer, L., Lamberton, F., Bokde, A. L. W., Ewers, M., Faluyi, Y. O., Tanner, C., Mazoyer, B., O'Neill, D., Bartley, M., Collins, D. R., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0032441 · Cited by 117 · see citing works
Electrophysiological analysis of visual function in mutant mice
Peachey, N. S., & Ball, S. L. (2003) · Documenta Ophthalmologica · doi:10.1023/a:1024448314608 · Cited by 114 · see citing works
Colaianna, M., Tucci, P., Zotti, M., Morgese, M. G., Schiavone, S., Govoni, S. M., Cuomo, V., & Trabace, L. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00669.x · Cited by 107 · see citing works
A diffusion tensor MRI study of patients with MCI and AD with a 2-year clinical follow-up
Scola, E., Bozzali, M., Agosta, F., Magnani, G., Franceschi, M., Sormani, M. P., Cercignani, M., Pagani, E., Falautano, M., Filippi, M., et al. (2010) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.2009.189639 · Cited by 98 · see citing works
Radial diffusivity in remote optic neuritis discriminates visual outcomes
Naismith, R. T., Xu, J., Tutlam, N. T., Trinkaus, K. M., Cross, A. H., & Song, S. (2010) · Neurology · doi:10.1212/wnl.0b013e3181e0434d · Cited by 93 · see citing works
Mizoguchi, H., Takuma, K., Fukuzaki, E., Ibi, D., Someya, E., Akazawa, K., Alkam, T., Tsunekawa, H., Mouri, A., Noda, Y., et al. (2009) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.109.154724 · Cited by 87 · see citing works
Amyloid-Beta Peptide Is Toxic to Neurons In Vivo via Indirect Mechanisms
Walsh, D. T., Montero, R., Bresciani, L. G., Jen, A., Leclercq, P. D., Saunders, D., EL-Amir, A. N., Gbadamoshi, L., Gentleman, S. M., & Jen, L. (2002) · Neurobiology of Disease · doi:10.1006/nbdi.2002.0485 · Cited by 66 · see citing works
Retinal Microvascular Signs and Cognitive Impairment
Liew, G., Mitchell, P., Wong, T. Y., Lindley, R. I., Cheung, N., Kaushik, S., & Wang, J. J. (2009) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2009.02459.x · Cited by 62 · see citing works
Maurice, T., Lockhart, B. P., Su, T., & Privat, A. (1996) · Brain Research · doi:10.1016/0006-8993(96)00710-x · Cited by 60 · see citing works
Optic Nerve Imaging in Multiple Sclerosis
Hickman, S. J. (2007) · Journal of Neuroimaging · doi:10.1111/j.1552-6569.2007.00136.x · Cited by 57 · see citing works
Takeda, S., Sato, N., Niisato, K., Takeuchi, D., Kurinami, H., Shinohara, M., Rakugi, H., Kano, M., & Morishita, R. (2009) · Brain Research · doi:10.1016/j.brainres.2009.05.035 · Cited by 56 · see citing works
Diffusion Tensor MR Study of Optic Nerve Degeneration in Glaucoma
Hui, E. S. K., Fu, Q., So, K., & Wu, E. X. (2007) · Conference proceedings · doi:10.1109/iembs.2007.4353290 · Cited by 48 · see citing works
Hong, Y. J., Yoon, B., Lim, S.-C., Shim, Y. S., Kim, J.-Y., Ahn, K. J., Han, I.-W., & Yang, D. W. (2013) · Neurological Sciences · doi:10.1007/s10072-012-1225-4 · Cited by 48 · see citing works
Walsh, D. T., Bresciani, L. G., Saunders, D., Manca, M. F., Jen, A., Gentleman, S., & Jen, L. S. (2005) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2005.00666.x · Cited by 44 · see citing works
The Role of MRI and PET/SPECT in Alzheimers Disease
Coimbra, A., Williams, D., & Hostetler, E. D. (2006) · Current Topics in Medicinal Chemistry · doi:10.2174/156802606776743075 · Cited by 43 · see citing works
Harms, M. P., Kotyk, J. J., & Merchant, K. M. (2006) · Experimental Neurology · doi:10.1016/j.expneurol.2006.01.002 · Cited by 38 · see citing works
The Disturbances of Object Vision and Spatial Vision in Alzheimer's Disease
Fujimori, M., Imamura, T., Yamashita, H., Hirono, N., & Mori, E. (1997) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000106635 · Cited by 37 · see citing works
Effects of Aβ25–35on neurogenesis in the adult mouse subventricular zone and dentate gyrus
Li, X., & Zuo, P. (2005) · Neurological Research · doi:10.1179/016164105x35585 · Cited by 26 · see citing works
Bitner, B. R., Pérez‐Torres, C. J., Hu, L., Inoue, T., & Pautler, R. G. (2012) · Magnetic Resonance Insights · doi:10.4137/mri.s9352 · Cited by 15 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Manno, F. A. M., Isla, A. G., Manno, S. H. C., Ahmed, I., Cheng, S. H., Barrios, F. A., & Lau, C. (2019) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2019.00039 · Cited by 49 · see citing works
Badea, A., Kane, L., Anderson, R. J., Qi, Y., Foster, M., Cofer, G. P., Medvitz, N., Buckley, A. F., Badea, A. K., Wetsel, W. C., et al. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.08.014 · Cited by 39 · see citing works
Whittaker, H. T., Zhu, S., Di Curzio, D. L., Buist, R., Li, X.-M., Noy, S., Wiseman, F. K., Thiessen, J. D., & Martin, M. (2018) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2018.03.010 · Cited by 12 · see citing works
Müller, H.-P., Roselli, F., Rasche, V., & Kassubek, J. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00734 · Cited by 12 · see citing works
Han, X., Hu, R., Ping, X., Chen, J., Liu, J., Liu, Z., Jin, X., Gao, X., Lin, M., Zhao, Y., et al. (2026) · Alzheimer's & Dementia · doi:10.1002/alz.71908
- Authors
- Sun, S.-W., Liang, H.-F., Mei, J., Xu, D., & Shi, W.-X.
- Affiliations
- University of California, Riverside (US)
- Loma Linda University (US)
- ORCID
- Shi, Wei-Xing
- Venue
- Journal of Alzheimer s Disease
- Publisher
- SAGE Publications
- Published
- 2013-10-29
- Volume
- 38
- Issue
- 1
- Pages
- 93-101
- ISSN
- 1387-2877 (ISSN-L)
- 1875-8908
- PMC
- PMC3962204
- OpenAlex
- W1495248241
- Cited by
- 27
- References
- 58
- Citations by year
- 2026: 3 · 2025: 1 · 2024: 1 · 2023: 3 · 2022: 1 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 3 · 2014: 1
- FWCI
- 1.81
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Journal of Alzheimer s Disease (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- The Scholars Repository - LLU (Loma Linda University) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS062830)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- amyloid-beta 42, white matter injury
- MeSH terms
- Animals, Body Weight, Disease Models, Animal, Myelin Basic Protein, Evoked Potentials, Visual, Female, Functional Laterality, Male, Mice, Inbred C57BL, Optic Nerve, Peptide Fragments, Amyloid beta-Peptides, Neurofilament Proteins, Diffusion Magnetic Resonance Imaging, Mice, Leukoencephalopathies
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
