Reduced hippocampal glutamate in Alzheimer disease

“Mini-mental state”

Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975) · Journal of Psychiatric Research · doi:10.1016/0022-3956(75)90026-6 · Cited by 88,282

An Algorithm for Least-Squares Estimation of Nonlinear Parameters

Marquardt, D. W. (1963) · Journal of the Society for Industrial and Applied Mathematics · doi:10.1137/0111030 · Cited by 30,728

Assessment of Older People: Self-Maintaining and Instrumental Activities of Daily Living

Lawton, M. P., & Brody, E. M. (1969) · The Gerontologist · doi:10.1093/geront/9.3_part_1.179 · Cited by 18,540

Current concepts in mild cognitive impairment

Petersen, R. C., Doody, R., Kurz, A., Mohs, R. C., Morris, J. C., Rabins, P. V., Ritchie, K., Rossor, M., Thal, L., & Winblad, B. (2001) · Archives of Neurology · doi:10.1001/archneur.58.12.1985 · Cited by 4,781

Cornell scale for depression in dementia

Alexopoulos, G. S., Abrams, R. C., Young, R. C., & Shamoian, C. A. (1988) · Biological Psychiatry · doi:10.1016/0006-3223(88)90038-8 · Cited by 2,678

Clinical Dementia Rating: A Reliable and Valid Diagnostic and Staging Measure for Dementia of the Alzheimer Type

Morris, J. C. (1997) · International Psychogeriatrics · doi:10.1017/s1041610297004870 · Cited by 1,641

Natural Oligomers of the Alzheimer Amyloid-β Protein Induce Reversible Synapse Loss by Modulating an NMDA-Type Glutamate Receptor-Dependent Signaling Pathway

Shankar, G. M., Bloodgood, B. L., Townsend, M., Walsh, D. M., Selkoe, D. J., & Sabatini, B. L. (2007) · The Journal of Neuroscience · doi:10.1523/jneurosci.4970-06.2007 · Cited by 1,592

Multimodal image coregistration and partitioning--a unified framework.

Ashburner, J., & Friston, K. (1997) · NeuroImage · doi:10.1006/nimg.1997.0290 · Cited by 1,051

The Return of the Frequency Sweep: Designing Adiabatic Pulses for Contemporary NMR

Garwood, M., & DelaBarre, L. J. (2001) · Journal of Magnetic Resonance · doi:10.1006/jmre.2001.2340 · Cited by 974

Multinuclear NMR Studies on the Energy Metabolism of Glial and Neuronal Cells

Brand, A., Richter‐Landsberg, C., & Leibfritz, D. (1994) · Developmental Neuroscience · doi:10.1159/000111347 · Cited by 889

Clinical Proton MR Spectroscopy in Central Nervous System Disorders

Öz, G., Alger, J. R., Barker, P. B., Bartha, R., Bizzi, A., Boesch, C., Bolan, P. J., Brindle, K. M., Cudalbu, C., Di̇nçer, A., et al. (2014) · Radiology · doi:10.1148/radiol.13130531 · Cited by 663

Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration

Andersen, J. V., Markussen, K. H., Jakobsen, E., Schousboe, A., Waagepetersen, H. S., Rosenberg, P. A., & Aldana, B. I. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108719 · Cited by 392

Magnetic Resonance Spectroscopy to Assess NeuroInflammation and Neuropathic Pain

Chang, L., Munsaka, S. M., Kraft-Terry, S. D., & Ernst, T. M. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9460-x · Cited by 306

On the early diagnosis of Alzheimer's Disease from multimodal signals: A survey

Alberdi, A., Aztiria, A., & Basarab, A. (2016) · Artificial Intelligence in Medicine · doi:10.1016/j.artmed.2016.06.003 · Cited by 231

Tau oligomers and aggregation in Alzheimer’s disease

Meraz‐Ríos, M. A., León, K. I. L.-D., Campos‐Peña, V., Anda-Hernández, M. A. D., & Mena‐López, R. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06511.x · Cited by 216

Alzheimer’s disease: Targeting the glutamatergic system

Conway, M. E. (2020) · Biogerontology · doi:10.1007/s10522-020-09860-4 · Cited by 180

‘Too much good news’ – are Alzheimer mouse models trying to tell us how to prevent, not cure, Alzheimer's disease?

Zahs, K. R., & Ashe, K. H. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.05.004 · Cited by 179

Hippocampal plasticity during the progression of Alzheimer’s disease

Mufson, E. J., Mahady, L. J., Waters, D., Counts, S., Perez, S. E., DeKosky, S. T., Ginsberg, S. D., Ikonomović, M. D., Scheff, S. W., & Binder, L. I. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.03.006 · Cited by 184

Magnetic resonance imaging of the Amine–Proton EXchange (APEX) dependent contrast

Jin, T., Wang, P., Zong, X., & Kim, S. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.08.014 · Cited by 169

Toward a Predictive Model of Alzheimer’s Disease Progression Using Capillary Electrophoresis–Mass Spectrometry Metabolomics

Ibáñez, C., Simó, C., Martín‐Álvarez, P. J., Kivipelto, M., Winblad, B. G., Cedazo-Mı́nguez, Á., & Cifuentes, A. (2012) · Analytical Chemistry · doi:10.1021/ac301243k · Cited by 168

The Dual Role of Glutamatergic Neurotransmission in Alzheimer’s Disease: From Pathophysiology to Pharmacotherapy

Bukke, V. N., Archana, M., Villani, R., Romano, A. D., Wawrzyniak, A., Balawender, K., Orkisz, S., Beggiato, S., Serviddio, G., & Cassano, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207452 · Cited by 161

Na+ and K+ ion imbalances in Alzheimer's disease

Vitvitsky, V., Garg, S. K., Keep, R. F., Albin, R. L., & Banerjee, R. V. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2012.07.004 · Cited by 170

Imaging of glutamate neurotransmitter alterations in Alzheimer's disease

Haris, M., Nath, K., Cai, K., Singh, A. K., Crescenzi, R. L., Kogan, F., Verma, G., Reddy, S., Hariharan, H., Melhem, E. R., et al. (2012) · NMR in Biomedicine · doi:10.1002/nbm.2875 · Cited by 152

Altered synapses and gliotransmission in Alzheimer's disease and AD model mice

Mitew, S., Kirkcaldie, M. T. K., Dickson, T. C., & Vickers, J. C. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.04.010 · Cited by 138

Magnetic resonance spectroscopy in mild cognitive impairment: Systematic review and meta-analysis

Tumati, S., Martens, S., & Aleman, A. (2013) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2013.08.004 · Cited by 135

Glutathione relates to neuropsychological functioning in mild cognitive impairment

Duffy, S. L., Lagopoulos, J., Hickie, I. B., Diamond, K., Graeber, M. B., Lewis, S. J. G., & Naismith, S. L. (2013) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.01.005 · Cited by 132

Brain Glutamate Levels Are Decreased in Alzheimer’s Disease: A Magnetic Resonance Spectroscopy Study

Fayed, N., Modrego, P. J., Rojas-Salinas, G., & Aguilar, K. (2011) · American Journal of Alzheimer's Disease & Other Dementias® · doi:10.1177/1533317511421780 · Cited by 128

Glutamate-glutamine and GABA in brain of normal aged and patients with cognitive impairment

Huang, D., Liu, D., Yin, J., Qian, T., Shrestha, S., & Ni, H. (2016) · European Radiology · doi:10.1007/s00330-016-4669-8 · Cited by 127

Amyloid Beta-Related Alterations to Glutamate Signaling Dynamics During Alzheimer’s Disease Progression

Findley, C. A., Bartke, A., Hascup, K. N., & Hascup, E. R. (2019) · ASN NEURO · doi:10.1177/1759091419855541 · Cited by 133

Glutamatergic alterations and mitochondrial impairment in a murine model of Alzheimer disease

Cassano, T., Serviddio, G., Gaetani, S., Romano, A., Dipasquale, P., Cianci, S., Bellanti, F., Laconca, L., Romano, A. D., Padalino, I., et al. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.09.021 · Cited by 102

Glutamate and Mitochondria: Two Prominent Players in the Oxidative Stress-Induced Neurodegeneration

Cassano, T., Pace, L., Bedse, G., Lavecchia, A. M., Marco, F. D., Gaetani, S., & Serviddio, G. (2015) · Current Alzheimer Research · doi:10.2174/1567205013666151218132725 · Cited by 96

Neurometabolites and associations with cognitive deficits in mild cognitive impairment: a magnetic resonance spectroscopy study at 7 Tesla

Oeltzschner, G., Wijtenburg, S. A., Mikkelsen, M. E., Edden, R. A. E., Barker, P. B., Joo, J. H., Leoutsakos, J., Rowland, L. M., Workman, C. I., & Smith, G. S. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.09.027 · Cited by 87

Magnetic resonance spectroscopy in Alzheimer’s disease

Kantarci, K., & Radford, G. (2013) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s35440 · Cited by 87

Posterior cingulate γ-aminobutyric acid and glutamate/glutamine are reduced in amnestic mild cognitive impairment and are unrelated to amyloid deposition and apolipoprotein E genotype

Riese, F., Gietl, A. F., Zoelch, N., Henning, A., Tuura, R., Kälin, A. M., Leh, S. E., Buck, A., Warnock, G., Edden, R. A. E., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.07.030 · Cited by 81

Serum Amino Acid Profiles in Normal Subjects and in Patients with or at Risk of Alzheimer Dementia

Corso, G., Cristofano, A., Sapere, N., la Marca, G., Angiolillo, A., Vitale, M., Fratangelo, R., Lombardi, T., Porcile, C., Intrieri, M., et al. (2017) · Dementia and Geriatric Cognitive Disorders Extra · doi:10.1159/000466688 · Cited by 81

A comprehensive multiomics approach toward understanding the relationship between aging and dementia

Currais, A. J. M., Goldberg, J., Farrokhi, C. B., Chang, M. W., Prior, M., Dargusch, R., Daugherty, D., Armando, A. M., Quehenberger, O., Maher, P. A., et al. (2015) · Aging · doi:10.18632/aging.100838 · Cited by 77

In vivo measurement of glutamate loss is associated with synapse loss in a mouse model of tauopathy

Crescenzi, R., DeBrosse, C., Nanga, R. P. R., Reddy, S., Haris, M., Hariharan, H., Iba, M., Lee, V. M. Y., Detre, J. A., Borthakur, A., et al. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.06.067 · Cited by 73

Glutamine metabolism in diseases associated with mitochondrial dysfunction

Bornstein, R., Mulholland, M. T., Sedensky, M. M., Morgan, P. G., & Johnson, S. C. (2023) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2023.103887 · Cited by 73

Whole-brain patterns of 1H-magnetic resonance spectroscopy imaging in Alzheimer's disease and dementia with Lewy bodies

Su, L., Blamire, A. M., Watson, R., He, J., Hayes, L., & O'Brien, J. T. (2016) · Translational Psychiatry · doi:10.1038/tp.2016.140 · Cited by 69

Advances in MRI Biomarkers for the Diagnosis of Alzheimer’s Disease

Kehoe, E. G., McNulty, J. P., Mullins, P. G., & Bokde, A. L. W. (2014) · Biomarkers in Medicine · doi:10.2217/bmm.14.42 · Cited by 70

Cell adhesion molecules in Alzheimer's disease

Nielsen, H. M., & Wennström, M. (2012) · Degenerative Neurological and Neuromuscular Disease · doi:10.2147/dnnd.s19829 · Cited by 60

Absolute Quantification in Proton Magnetic Resonance Spectroscopy Is Useful to Differentiate Amnesic Mild Cognitive Impairment from Alzheimer’s Disease and Healthy Aging

Watanabe, T., Shiino, A., & Akiguchi, I. (2010) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000318750 · Cited by 63

Glutamate metabolism is impaired in transgenic mice with tau hyperphosphorylation

Nilsen, L. H., Rae, C., Ittner, L. M., Götz, J., & Sonnewald, U. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2012.212 · Cited by 62

Reversal of Metabolic Deficits by Lipoic Acid in a Triple Transgenic Mouse Model of Alzheimer's Disease: A 13C NMR Study

Sancheti, H., Kanamori, K., Patil, I., Diaz-Brinton, R., Ross, B., & Cadenas, E. (2014) · Journal of Cerebral Blood Flow and Metabolism · doi:10.1038/jcbfm.2013.196 · Cited by 60

Increased glutamate in the hippocampus after galantamine treatment for Alzheimer disease

Penner, J., Rupsingh, R., Smith, M., Wells, J., BORRIE, M. J., & Bartha, R. (2009) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2009.10.007 · Cited by 57

1H NMR Metabolomic Signatures in Five Brain Regions of the AβPPswe Tg2576 Mouse Model of Alzheimer's Disease at Four Ages

Lalande-Martin, J., Halley, H., Balayssac, S., Gilard, V., Dejean, S., Martino, R., Francès, B., Lassalle, J., & Malet‐Martino, M. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-130023 · Cited by 60

NSCs promote hippocampal neurogenesis, metabolic changes and synaptogenesis in APP/PS1 transgenic mice

Zhang, W., Gu, G., Zhang, Q., Liu, J., Zhang, B., Guo, Y. C., Wang, M., Gong, Q., & Xu, J. (2017) · Hippocampus · doi:10.1002/hipo.22794 · Cited by 57

Reduced Hippocampal Glutamate and Posterior Cingulate N-Acetyl Aspartate in Mild Cognitive Impairment and Alzheimer’s Disease Is Associated with Episodic Memory Performance and White Matter Integrity in the Cingulum: A Pilot Study

Wong, D. Y., Atiya, S., Fogarty, J., Montero‐Odasso, M., Pasternak, S., Brymer, C., BORRIE, M. J., & Bartha, R. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-190773 · Cited by 56

Hippocampal metabolites in asthma and their implications for cognitive function

Kroll, J. L., Steele, A. M., Pinkham, A. E., Choi, C., Khan, D. A., Patel, S. V., Chen, J. R., Aslan, S., Brown, E. S., & Ritz, T. (2018) · NeuroImage Clinical · doi:10.1016/j.nicl.2018.04.012 · Cited by 55

Higher Glutamate + Glutamine and Reduction of N-acetylaspartate in Posterior Cingulate According to Age Range in Patients with Cognitive Impairment and/or Pain

Fayed, N. M., Andres, E. M., Viguera, L., Modrego, P. J., & García‐Campayo, J. (2014) · Academic Radiology · doi:10.1016/j.acra.2014.04.009 · Cited by 54

Feasibility and reproducibility of neurochemical profile quantification in the human hippocampus at 3 T

Bednařík, P., Moheet, A. A., Deelchand, D. K., Emir, U. E., Eberly, L. E., Bareš, M., Seaquist, E. R., & Öz, G. (2015) · NMR in Biomedicine · doi:10.1002/nbm.3309 · Cited by 54

Errors in 1H‐MRS estimates of brain metabolite concentrations caused by failing to take into account tissue‐specific signal relaxation

Gasparovic, C., Chen, H., & Mullins, P. G. (2018) · NMR in Biomedicine · doi:10.1002/nbm.3914 · Cited by 53

Proton and Phosphorus Magnetic Resonance Spectroscopy of a Mouse Model of Alzheimer's Disease

Mlynárik, V., Cacquevel, M., Sun-Reimer, L., Janssens, S., Cudalbu, C., Lei, H., Schneider, B. L., Aebischer, P., & Rolf Gruetter, A. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2012-112072 · Cited by 52

Electroacupuncture ameliorate learning and memory by improving N-acetylaspartate and glutamate metabolism in APP/PS1 mice

Lin, R., Li, L., Zhang, Y., Huang, S., Chen, S., Shi, J., Zhuo, P., Jin, H., Li, Z., Liu, W., et al. (2018) · Biological Research · doi:10.1186/s40659-018-0166-7 · Cited by 52

Proton MR Spectroscopy–Detectable Major Neurotransmitters of the Brain: Biology and Possible Clinical Applications

Agarwal, N., & Renshaw, P. F. (2011) · American Journal of Neuroradiology · doi:10.3174/ajnr.a2587 · Cited by 51

Modulating the Balance of Synaptic and Extrasynaptic NMDA Receptors Shows Positive Effects against Amyloid-β-Induced Neurotoxicity

Huang, Y. Y., Shen, W., Su, J., Cheng, B., Li, D., Liu, G., Zhou, W., & Zhang, Y. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161186 · Cited by 54

Activity of Selected Group of Monoterpenes in Alzheimer’s Disease Symptoms in Experimental Model Studies—A Non-Systematic Review

Wojtunik‐Kulesza, K. A., Rudkowska, M., Kasprzak‐Drozd, K., Oniszczuk, A., & Borowicz, K. K. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22147366 · Cited by 51

Down‐regulation of glutamatergic terminals (VGLUT1) driven by Aβ in Alzheimer's disease

Rodriguez‐Perdigon, M., Tordera, R. M., Gil-Bea, F. J., Gereñu, G., Ramírez, M. J., & Solas, M. (2016) · Hippocampus · doi:10.1002/hipo.22607 · Cited by 49

Magnetic Resonance Spectroscopy in Common Dementias

Kantarci, K. (2013) · Neuroimaging Clinics of North America · doi:10.1016/j.nic.2012.10.004 · Cited by 49

Protein and amino acid supplementation in older humans

Fukagawa, N. K. (2013) · Amino Acids · doi:10.1007/s00726-013-1480-6 · Cited by 43

Altered neurochemical profile in the M cGill‐ R ‐ T hy1‐ APP rat model of A lzheimer's disease: a longitudinal in vivo 1 H MRS study

Nilsen, L. H., Melø, T. M., Sæther, O., Witter, M. P., & Sonnewald, U. (2012) · Journal of Neurochemistry · doi:10.1111/jnc.12003 · Cited by 43

Neurochemicals, Behaviours and Psychiatric Perspectives of Neurological Diseases

Choudhury, A., Sahu, T., Ramanujam, P. L., Banerjee, A. K., Chakraborty, I., Arun Kumar, R., & Arora, N. (2018) · Neuropsychiatry · doi:10.4172/neuropsychiatry.1000361 · Cited by 41

The role of Smo-Shh/Gli signaling activation in the prevention of neurological and ageing disorders

Prajapati, A., Mehan, S., & Khan, Z. (2023) · Biogerontology · doi:10.1007/s10522-023-10034-1 · Cited by 40

Glutamate: Molecular Mechanisms and Signaling Pathway in Alzheimer’s Disease, a Potential Therapeutic Target

Puranik, N., & Song, M. (2024) · Molecules · doi:10.3390/molecules29235744 · Cited by 49

Decreased Glutamate Levels in Patients with Amnestic Mild Cognitive Impairment: An sLASER Proton MR Spectroscopy and PiB‐PET Study

Zeydan, B., Deelchand, D. K., Tosakulwong, N., Lesnick, T. G., Kantarci, O. H., Machulda, M. M., Knopman, D. S., Lowe, V. J., Jack, C. R., Petersen, R. C., et al. (2017) · Journal of Neuroimaging · doi:10.1111/jon.12454 · Cited by 37

Regional proton magnetic resonance spectroscopy patterns in dementia with Lewy bodies

Graff‐Radford, J., Boeve, B. F., Murray, M. E., Ferman, T. J., Tosakulwong, N., Lesnick, T. G., Maroney‐Smith, M., Senjem, M. L., Gunter, J. L., Smith, G. E., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.01.001 · Cited by 36

Increased hippocampal CA1 density of serotonergic terminals in a triple transgenic mouse model of Alzheimer's disease: an ultrastructural study

Noristani, H. N., Meadows, R. S., Olabarria, M., Verkhratsky, A., & Rodríguez, J. J. (2011) · Cell Death and Disease · doi:10.1038/cddis.2011.79 · Cited by 36

Age dependency of mGluR5 availability in 5xFAD mice measured by PET

Lee, M., Lee, H., Jeong, Y. J., Oh, S. J., Kang, K. J., Han, S. J., Nam, K. R., Lee, Y. J., Lee, K. C., Ryu, Y. H., et al. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2019.08.006 · Cited by 33

MRS in neurodegenerative dementias, prodromal syndromes and at‐risk states: A systematic review of the literature

McKiernan, E. F., Su, L., & O'Brien, J. T. (2023) · NMR in Biomedicine · doi:10.1002/nbm.4896 · Cited by 33

Increased astroglial activity and reduced neuronal function across brain in AβPP-PS1 mouse model of Alzheimer’s disease

Patel, A. B., Tiwari, V., Veeraiah, P., & Saba, K. (2017) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x17709463 · Cited by 34

Glutamatergic dysfunction in neurodegenerative diseases focusing on Parkinson's disease: Role of glutamate modulators

Almohmadi, N. H., Al-Kuraishy, H. M., Al-Gareeb, A. I., Albuhadily, A. K., Abdelaziz, A. M., Jabir, M. S., Alexiou, A. T., Papadakis, M., & Batiha, G. E. (2025) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2025.111349 · Cited by 35

Optimized in vivo brain glutamate measurement using long‐echo‐time semi‐LASER at 7 T

Wong, D. Y., Schranz, A. L., & Bartha, R. (2018) · NMR in Biomedicine · doi:10.1002/nbm.4002 · Cited by 32

GABA and glutamate moderate beta-amyloid related functional connectivity in cognitively unimpaired old-aged adults

Quevenco, F. C., Schreiner, S. J., Preti, M. G., Bergen, J. M. G. V., Kirchner, T., Wyss, M. T., Steininger, S. C., Gietl, A. F., Leh, S. E., Buck, A., et al. (2019) · NeuroImage Clinical · doi:10.1016/j.nicl.2019.101776 · Cited by 31

Metabolomics in aging research: aging markers from organs

Fang, W., Chen, S., Jin, X., Liu, S., Cao, X., & Liu, B. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1198794 · Cited by 30

Advances in High-Field Magnetic Resonance Spectroscopy in Alzheimer’s Disease

Zhang, N., Song, X., Bartha, R., Beyea, S., D’Arcy, R. C. N., Zhang, Y., & Rockwood, K. J. (2014) · Current Alzheimer Research · doi:10.2174/1567205011666140302200312 · Cited by 30

Cervical Spondylotic Myelopathy: Metabolite Changes in the Primary Motor Cortex after Surgery

Aleksanderek, I., McGregor, S. M. K., Stevens, T. K., Goncalves, S., Bartha, R., & Duggal, N. (2016) · Radiology · doi:10.1148/radiol.2016152083 · Cited by 29

Cerebral blood flow and metabolic changes in hippocampal regions of a modified rat model with chronic cerebral hypoperfusion

Jian, H., Yi-Fang, W., Qi, L., Huang, X.-S., & Zhang, G. (2012) · Acta Neurologica Belgica · doi:10.1007/s13760-012-0154-6 · Cited by 29

A novel phenoxy thiophene sulphonamide molecule protects against glutamate evoked oxidative injury in a neuronal cell model

Gliyazova, N. S., Huh, E. Y., & Ibeanu, G. C. (2013) · BMC Neuroscience · doi:10.1186/1471-2202-14-93 · Cited by 28

Novel Blood Biomarkers that Correlate with Cognitive Performance and Hippocampal Volumetry: Potential for Early Diagnosis of Alzheimer’s Disease

Hudd, F., Shiel, A., Harris, M., Bowdler, P., McCann, B., Tsivos, D., Wearn, A., Knight, M., Kauppinen, R., Coulthard, E., et al. (2019) · Journal of Alzheimer's Disease · doi:10.3233/jad-180879 · Cited by 26

Magnetic resonance spectroscopy analysis of neurochemical changes in the atrophic hippocampus of APP/PS1 transgenic mice

Liang, S., Huang, J., Liu, W., Jin, H., Li, L., Zhang, X., Nie, B., Lin, R., Tao, J., Zhao, S., et al. (2017) · Behavioural Brain Research · doi:10.1016/j.bbr.2017.08.005 · Cited by 26

Miniaturized Electrochemical Sensing Platforms for Quantitative Monitoring of Glutamate Dynamics in the Central Nervous System

Wang, Q., Yang, C., Chen, S., & Li, J. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202406867 · Cited by 26

Role of emerging neuroimaging modalities in patients with cognitive impairment: a review from the Canadian Consensus Conference on the Diagnosis and Treatment of Dementia 2012

Burhan, A. M., Bartha, R., Bocti, C., BORRIE, M. J., Laforce, R. J., Rosa‐Neto, P., & Soucy, J. (2013) · Alzheimer s Research & Therapy · doi:10.1186/alzrt200 · Cited by 24

GABA decrease is associated with degraded neural specificity in the visual cortex of glaucoma patients

Bang, J. W., Parra, C., Yu, K., Wollstein, G., Schuman, J. S., & Chan, K. C. (2023) · Communications Biology · doi:10.1038/s42003-023-04918-8 · Cited by 24

Danggui-Shaoyao-San Improves Learning and Memory in Female SAMP8 via Modulation of Estradiol

Huang, Y.-J., Hu, Z., Yuan, H., Shu, L., Liu, G., Qiao, S.-Y., Sun, L., Zhou, W.-X., & Zhang, Y.-X. (2014) · Evidence-Based Complementary and Alternative Medicine · doi:10.1155/2014/327294 · Cited by 22

Glutamate-Weighted CEST Contrast After Removal of Magnetization Transfer Effect in Human Brain and Rat Brain with Tumor

Debnath, A., Hariharan, H., Nanga, R. P. R., Reddy, R. D., & Singh, A. K. (2020) · Molecular Imaging and Biology · doi:10.1007/s11307-019-01465-9 · Cited by 21

1H MR spectroscopy biomarkers of neuronal and synaptic function are associated with tau deposition in cognitively unimpaired older adults

Kara, F., Joers, J. M., Deelchand, D. K., Park, Y. W., Przybelski, S. A., Lesnick, T. G., Senjem, M. L., Zeydan, B., Knopman, D. S., Lowe, V. J., et al. (2022) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.12.010 · Cited by 22

Alzheimer-like brain metabolic and structural features in cholesterol-fed rabbit detected by magnetic resonance imaging

Jin, P., Pan, Y., Pan, Z., Xu, J., Lin, M. T., Sun, Z., Chen, M., & Xu, M. (2018) · Lipids in Health and Disease · doi:10.1186/s12944-018-0705-9 · Cited by 21

Saturation Transfer MRI for Detection of Metabolic and Microstructural Impairments Underlying Neurodegeneration in Alzheimer’s Disease

Orzyłowska, A., & Oakden, W. (2021) · Brain Sciences · doi:10.3390/brainsci12010053 · Cited by 20

Memantine hydrochloride in the treatment of dementia subtypes

Peng, D., Yuan, X., & Zhu, R. (2013) · Journal of Clinical Neuroscience · doi:10.1016/j.jocn.2013.02.041 · Cited by 21

3T hippocampal glutamate-glutamine complex reflects verbal memory decline in aging

Nikolova, S., Stark, S. M., & Stark, C. E. L. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.01.026 · Cited by 21

Early Differences in Dorsal Hippocampal Metabolite Levels in Males But Not Females in a Transgenic Rat Model of Alzheimer’s Disease

Nilsen, L. H., Melø, T. M., Witter, M. P., & Sonnewald, U. (2013) · Neurochemical Research · doi:10.1007/s11064-013-1222-x · Cited by 20

1 H-Proton Magnetic Resonance Spectroscopy Differentiates Dementia with Lewy Bodies from Alzheimer's Disease

Zhong, X., Shi, H., Shen, Z., Hou, L., Luo, X., Chen, X., Liu, S., Zhang, Y., Zheng, D., Tan, Y. L., et al. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-131517 · Cited by 19

A Longitudinal Study of Cognition, Proton MR Spectroscopy and Synaptic and Neuronal Pathology in Aging Wild-type and AβPPswe-PS1dE9 Mice

Jansen, D., Zerbi, V., Janssen, C. I. F., Dederen, P. J. W. C., Mutsaers, M. P. C., Hafkemeijer, A., Janssen, A.-L., Nobelen, C. L. M., Veltien, A. A., van Asten, J. J. A., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0063643 · Cited by 19

CEST imaging combined with 1H-MRS reveal the neuroprotective effects of riluzole by improving neurotransmitter imbalances in Alzheimer’s disease mice

Shen, Y., Zhang, X., Liu, S.-Q., Xin, L., Xuan, W., Zhuang, C., Chen, Y., Chen, B., Zheng, X., Wu, R., et al. (2025) · Alzheimer s Research & Therapy · doi:10.1186/s13195-025-01672-3 · Cited by 18

Effects of Ultramicronized Palmitoylethanolamide on Mitochondrial Bioenergetics, Cerebral Metabolism, and Glutamatergic Transmission: An Integrated Approach in a Triple Transgenic Mouse Model of Alzheimer's Disease

Bellanti, F., Bukke, V. N., Moola, A., Villani, R., Scuderi, C., Steardo, L., Palombelli, G., Canese, R., Beggiato, S., Altamura, M., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.890855 · Cited by 18

Clinical benefits of green tea consumption for cognitive dysfunction

Ide, K., & Yamada, H. (2015) · PharmaNutrition · doi:10.1016/j.phanu.2015.07.001 · Cited by 19

Hippocampal Neurochemical Changes in Senescent Mice Induced with Chronic Injection of D-Galactose and NaNO2: An In Vitro High-Resolution NMR Spectroscopy Study at 9.4T

Lin, Y., Yao, J., Chen, Y., Pang, L., Li, H., Cao, Z., You, K., Dai, H., & Wu, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088562 · Cited by 19

Intracerebral synthesis of glutamine from hyperpolarized glutamate

Mazuel, L., Schulte, R. F., Cladière, A., Spéziale, C., Lagrée, M., Leremboure, M., Jean, B., Durif, F., & Chassain, C. (2016) · Magnetic Resonance in Medicine · doi:10.1002/mrm.26522 · Cited by 18

1H MR spectroscopy of the motor cortex immediately following transcranial direct current stimulation at 7 Tesla

Ryan, K., Wawrzyn, K., Gati, J. S., Chronik, B. A., Wong, D. Y., Duggal, N., & Bartha, R. (2018) · PLoS ONE · doi:10.1371/journal.pone.0198053 · Cited by 18

NCX1 and EAAC1 transporters are involved in the protective action of glutamate in an in vitro Alzheimer's disease-like model

Magi, S., Piccirillo, S., Maiolino, M., Lariccia, V., & Amoroso, S. (2020) · Cell Calcium · doi:10.1016/j.ceca.2020.102268 · Cited by 18

Magnetic resonance spectroscopy and brain volumetry in mild cognitive impairment. A prospective study

Fayed, N. M., Modrego, P. J., García‐Martí, G., Sanz‐Requena, R., & Martí‐Bonmatí, L. (2016) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2016.12.010 · Cited by 19

The relationship between measurement of in vivo brain glutamate and markers of iron metabolism: A proton magnetic resonance spectroscopy study in healthy adults

Burger, A., Kotze, M. J., Stein, D. J., van Rensburg, S. J., & Howells, F. M. (2019) · European Journal of Neuroscience · doi:10.1111/ejn.14583 · Cited by 17

Longitudinal Monitoring of Sex-Related in vivo Metabolic Changes in the Brain of Alzheimer's Disease Transgenic Mouse Using Magnetic Resonance Spectroscopy

van Duijn, S., Nabuurs, R. J. A., van Duinen, S. G., Natté, R., van Buchem, M. A., & Alia, A. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-122188 · Cited by 16

Magnetic resonance imaging of glutamate in neuroinflammation

Chen, Y., Dai, Z., Shen, Z., Lin, G., Zhuang, C., Li, H. J., & Wu, R. (2016) · Radiology of Infectious Diseases · doi:10.1016/j.jrid.2016.03.006 · Cited by 16

1H-MRS neurometabolites and associations with neurite microstructures and cognitive functions in amnestic mild cognitive impairment

Gozdas, E., Hinkley, L. M., Fingerhut, H., Dacorro, L., Gu, M., Sacchet, M. D., Hurd, R. E., & Hosseini, S. M. H. (2022) · NeuroImage Clinical · doi:10.1016/j.nicl.2022.103159 · Cited by 15

Microbiota-gut-brain axis dysregulation in Alzheimer’s disease and its modulation through probiotic supplementation

Marizzoni, M., Mombelli, E., Alboni, S., Rosa, M., Moretti, D. V., Mirabelli, P., Coppola, L., Luongo, D., Salamone, D., Saleri, S., et al. (2025) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2025.106138 · Cited by 17

Cholinergic neurotransmission in the brain of streptozotocin-induced rat model of sporadic Alzheimer’s disease: long-term follow up

Knezović, A., & Šalković‐Petrišić, M. (2025) · Journal of Neural Transmission · doi:10.1007/s00702-025-02887-2 · Cited by 15

Automated algorithm to measure changes in medial temporal lobe volume in Alzheimer disease

Kazemifar, S., Drozd, J. J., Rajakumar, N., BORRIE, M. J., & Bartha, R. (2014) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2014.01.033 · Cited by 15

Hippocampal Neurochemical Profile and Glucose Transport Kinetics in Patients With Type 1 Diabetes

Bednařík, P., Henry, P., Khowaja, A., Rubin, N., Kumar, A. D., Deelchand, D. K., Eberly, L. E., Seaquist, E. R., Öz, G., & Moheet, A. A. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz062 · Cited by 14

Hydrogen Proton Magnetic Resonance Spectroscopy in Multidomain Amnestic Mild Cognitive Impairment and Vascular Cognitive Impairment Without Dementia

Chen, S., Cai, Q., Shen, Y., Chuanxiao, X., Zhou, H., & Zhao, Z. (2016) · American Journal of Alzheimer s Disease & Other Dementias® · doi:10.1177/1533317515628052 · Cited by 15

Study of ~1H MR Spectroscopy in Hippocampus Metabolites of Alzheimer Disease

Jianpin, Q. (2009) · Radiologic Practice

Brain Glutamate Levels Are Decreased in Alzheimer’s Disease: A Magnetic Resonance Spectroscopy Study

Fayed, N., Modrego, P. J., Rojas-Salinas, G., & Aguilar, K. (2011) · American Journal of Alzheimer's Disease & Other Dementias® · doi:10.1177/1533317511421780 · Cited by 128

Metabolic Changes in Patients with Alzheimer's Disease Assessed by High Field Proton Magnetic Resonance Spectroscopy

Feng, X. (2010) · Chinese Computed Medical Imaging

Regional metabolic changes in the hippocampus and posterior cingulate area detected with 3-Tesla magnetic resonance spectroscopy in patients with mild cognitive impairment and alzheimer disease

Wang, Z., Zhao, C., Lei, Y., Zhou, W., & Li, K. (2009) · Acta Radiologica · doi:10.1080/02841850802709219 · Cited by 64

P2–349: Analysis of metabolite levels and ratios in age matched controls, mild cognitive impairment, and Alzheimer's disease converters using 1H magnetic resonance spectroscopy

Mueller, C., Bartnik‐Olson, B., Patra, S., Baqai, W. K., Petersen, F. F., Holshouser, B. A., & Kirsch, W. M. (2006) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2006.05.1189