Cited by 110Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

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c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice

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Cancino, Gonzalo I., Perez de Arce, Karen, Castro, Paula U., Toledo, Enrique M., von Bernhardi, Rommy, Alvarez, Alejandra R.·2011·Neurobiology of Aging

DOI 10.1016/j.neurobiolaging.2009.07.007

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Abstract

The c-Abl tyrosine kinase is an important link in signal transduction pathways that promote cytoskeletal rearrangement and apoptotic signalling. We have previously shown that amyloid-β-peptide (Aβ) activates c-Abl. Herein we show that c-Abl participates in Aβ-induced tau phosphorylation through Cdk5 activation. We found that intraperitoneal administration of STI571, a specific inhibitor for c-Abl kinase, decreased tau phosphorylation in the APPswe/PSEN1ΔE9 transgenic mouse brain. In addition, when neurons were treated with Aβ we observed: (i) an increase in active c-Abl and tau phosphorylation, (ii) the prevention of tau phosphorylation by STI571 and (iii) the inhibition of c-Abl expression by shRNA, as well as the expression of a c-Abl kinase death mutant, decreased AT8 and PHF1 signals. Furthermore, the increase of c-Abl was associated with Tyr15 phosphorylation of Cdk5 and its association with c-Abl. Brains from APPswe/PSEN1ΔE9 mice showed higher levels of c-Abl and phospho-Cdk5 than wild-type mice. Moreover, STI571 treatment decreased the phospho-Cdk5 levels. Together, the evidence suggests that activation of c-Abl by Aβ promotes tau phosphorylation through Tyr15 phosphorylation-mediated Cdk5 activation.

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Authors: Cancino, G. I., Perez de Arce, K., Castro, P. U., Toledo, E. M., von Bernhardi, R., & Alvarez, A. R.
Affiliations: Pontificia Universidad Católica de Chile (CL)
Corresponding author: Alvarez, Alejandra R.
ORCID: Cancino, Gonzalo I.
Toledo, Enrique M.
Alvarez, Alejandra R.
Venue: Neurobiology of Aging
Publisher: Elsevier BV
Published: 2011-07
Volume: 32
Issue: 7
Pages: 1249-1261
ISSN: 0197-4580 (ISSN-L)
DOI: 10.1016/j.neurobiolaging.2009.07.007
OpenAlex: W2012589975
Cited by: 110
References: 67
Citations by year: 2026: 1 · 2025: 11 · 2024: 5 · 2023: 10 · 2022: 9 · 2021: 7 · 2020: 8 · 2019: 5 · 2018: 6 · 2017: 2 · 2016: 7 · 2015: 7 · 2014: 8 · 2013: 8 · 2012: 4
FWCI: 3.53
Type: journal article
Language: en
Open access: green
americanae.aecid.es
Licence: other-oa
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Neurobiology of Aging (publishedVersion)
PubMed (publishedVersion)
Americanae (AECID Library) (submittedVersion, other-oa)
LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas) (submittedVersion, other-oa)
Funders: FONDECYT (1040782, 1080221)
FONDAP (13980001)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: c-Abl kinase, tau phosphorylation, cyclin-dependent kinase 5, amyloid-beta, Alzheimer's disease, imatinib, tau pathology, kinase inhibitors
MeSH terms: Alzheimer Disease, Animals, Cells, Cultured, Disease Models, Animal, Hippocampus, Humans, Mice, Transgenic, Phosphorylation, Proto-Oncogene Proteins c-abl, Amyloid beta-Protein Precursor, tau Proteins, Rats, Sprague-Dawley, Mice, Rats

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c-Abl tyrosine kinase modulates tau pathology and Cdk5 phosphorylation in AD transgenic mice

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