A survey of Cdk5 activator p35 and p25 levels in Alzheimer's disease brains
Open accessAbstract
P25, a calpain cleavage product of the cyclin‐dependent kinase 5 (Cdk5) activator p35, causes prolonged activation of Cdk5. Although p25 has been shown to accumulate in brains of patients with Alzheimer's disease (AD), it is not known whether p25 accumulation in AD is brain region‐specific. We analyzed the amounts of p25 and p35 in human autopsy samples from multiple brain regions including frontal cortex, inferior parietal cortex and hippocampus using immunoblotting assays. Our results show that the p25–p35 indices are higher in AD than in the control groups in all three brain regions. The most significant difference in p25–p35 indices between AD and control groups is in the frontal cortex. No significant difference in calpain activity between AD and control groups is observed, indicating that postmortem calpain activation cannot account for the elevation of p25/p35 ratios in AD brains. Our results support the notion that p25 accumulation deregulates Cdk5 activity in AD brains, and the deregulated Cdk5 activity may contribute to the pathogenesis of AD.
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Increased GSK3β expression and CDK5 activity, decreased expression of PP1 and PP2A, and decreased PP2A activity have been observed in specific brain regions in AD patients.
“In support of this, increased GSK3β expression and CDK5 activity, decreased expression of PP1 and PP2A, and decreased PP2A activity has been observed in specific brain regions in AD patients [148–152].”
From Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease (2020) · cites this paper as [149]
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- Authors
- Tseng, H.-C., Zhou, Y., Shen, Y., & Tsai, L.-H.
- Affiliations
- Howard Hughes Medical Institute (US)
- Banner Sun Health Research Institute (US)
- Corresponding author
- Tsai, Li-Huei
- Venue
- FEBS Letters
- Publisher
- Wiley
- Published
- 2002-06-18
- Volume
- 523
- Issue
- 1-3
- Pages
- 58-62
- ISSN
- 0014-5793 (ISSN-L)
- 1873-3468
- OpenAlex
- W2092765133
- Cited by
- 198
- References
- 20
- Citations by year
- 2026: 4 · 2025: 12 · 2024: 7 · 2023: 2 · 2022: 3 · 2021: 6 · 2020: 7 · 2019: 5 · 2018: 4 · 2017: 9 · 2016: 6 · 2015: 6 · 2014: 4 · 2013: 4 · 2012: 19
- FWCI
- 7.79
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- FEBS Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Alzheimer's Association
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Calpain Protease Function and Regulation
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, cyclin-dependent kinase 5, p35, p25, calpain cleavage, brain region-specific expression, frontal cortex, hippocampus, inferior parietal cortex, postmortem brain
- MeSH terms
- Alzheimer Disease, Brain, Calpain, Frontal Lobe, Hippocampus, Humans, Nerve Tissue Proteins, Parietal Lobe, Postmortem Changes
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