Implication of IL-33 gene polymorphism in Chinese patients with Alzheimer's disease
Abstract
Interleukin-33 (IL-33), a newly described member of the IL-1 family, is located on chromosome 9p24, a chromosomal region of interest in Alzheimer's disease (AD) defined by many genome-wide studies. Three intronic rs1157505, rs11792633, and rs7044343 single nucleotide polymorphisms (SNPs) within IL-33 have recently been reported to be associated with risk of AD in Caucasian populations. In order to assess the involvement of the IL-33 polymorphisms in the risk of developing late onset AD (LOAD), we analyzed the genotype and allele distributions of these 3 polymorphisms in 704 Han Chinese subjects. The minor alleles of the rs11792633 polymorphism within IL-33 was significantly associated with a reduced risk of LOAD (odds ratio [OR] = 0.73, p = 0.005). Furthermore, rs11792633 polymorphism was still strongly associated with LOAD (dominant model: OR = 0.67, p = 0.015; recessive model: OR 0.57, p = 0.021; additive model: OR = 0.71, p = 0.004) after adjusting for age, gender, and the apolipoprotein E (APOE) ε4 status. Our results support the evidence that genetic variants of IL-33 affect susceptibility to LOAD in Han Chinese.
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Observations in the murine AD model could be extrapolated to humans.
“Indeed, genetic studies have linked IL-33/ST2 single nucleotide polymorphisms to clinical AD (15,51), suggesting that our observations in the murine AD model could be extrapolated to humans.”
From IL-33 ameliorates Alzheimer's disease-like pathology and cognitive decline (2016) · cites this paper as [51]
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- Authors
- Yu, J.-T., Song, J.-H., Wang, N.-D., Wu, Z.-C., Zhang, Q., Zhang, N., Zhang, W., Xuan, S.-Y., & Tan, L.
- Affiliations
- Qingdao University (CN)
- Corresponding author
- Tan, Lan
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2012-05
- Volume
- 33
- Issue
- 5
- Pages
- 1014.e11-1014.e14
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2133619585
- Cited by
- 54
- References
- 17
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 3 · 2021: 8 · 2020: 1 · 2019: 2 · 2018: 3 · 2017: 5 · 2016: 8 · 2015: 1 · 2014: 7 · 2013: 3 · 2012: 1
- FWCI
- 2.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (30870884)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- IL-33, Alzheimer's disease, late-onset Alzheimer's disease, genetic susceptibility, Han Chinese, APOE ε4
- MeSH terms
- Interleukin-33, Aged, Aged, 80 and over, Alzheimer Disease, Female, Humans, Interleukins, Male, Polymorphism, Genetic, Risk Factors, Age of Onset, Age Distribution, Genetic Predisposition to Disease, Asian People
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