Role of IL-33 in inflammation and disease
Open accessAbstract
Interleukin (IL)-33 is a new member of the IL-1 superfamily of cytokines that is expressed by mainly stromal cells, such as epithelial and endothelial cells, and its expression is upregulated following pro-inflammatory stimulation. IL-33 can function both as a traditional cytokine and as a nuclear factor regulating gene transcription. It is thought to function as an 'alarmin' released following cell necrosis to alerting the immune system to tissue damage or stress. It mediates its biological effects via interaction with the receptors ST2 (IL-1RL1) and IL-1 receptor accessory protein (IL-1RAcP), both of which are widely expressed, particularly by innate immune cells and T helper 2 (Th2) cells. IL-33 strongly induces Th2 cytokine production from these cells and can promote the pathogenesis of Th2-related disease such as asthma, atopic dermatitis and anaphylaxis. However, IL-33 has shown various protective effects in cardiovascular diseases such as atherosclerosis, obesity, type 2 diabetes and cardiac remodeling. Thus, the effects of IL-33 are either pro- or anti-inflammatory depending on the disease and the model. In this review the role of IL-33 in the inflammation of several disease pathologies will be discussed, with particular emphasis on recent advances.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
CXCL10 and IL-33 might contribute to the amplification of inflammatory responses by acting on T-cells and innate immune cells.
“By acting on T-cells and innate immune cells (Miller, 2011; Brownell and Polyak, 2013), CXCL10 and IL-33 might contribute to the amplification of inflammatory responses.”
From Model Based Targeting of IL-6-Induced Inflammatory Responses in Cultured Primary Hepatocytes to Improve Application of the JAK Inhibitor Ruxolitinib (2017) · cites this paper as Miller, 2011
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
1 retracted
RETRACTED: The cytokine interleukin-33 mediates anaphylactic shock
Pushparaj, P. N., Tay, H. K., H’ng, S. C., Pitman, N. I., Xu, D., McKenzie, A. N. J., Liew, F. Y., & Melendez, A. J. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901206106 · Cited by 285 · see citing works
RetractedSchmitz, J., Owyang, A. M., Oldham, E. R., Song, Y., Murphy, E., McClanahan, T. K., Zurawski, G., Moshrefi, M., Qin, J., Li, X., et al. (2005) · Immunity · doi:10.1016/j.immuni.2005.09.015 · Cited by 3,701 · see citing works
The immune system in atherosclerosis
Hansson, G. K., & Hermansson, A. (2011) · Nature Immunology · doi:10.1038/ni.2001 · Cited by 2,331 · see citing works
Nuocytes represent a new innate effector leukocyte that mediates type-2 immunity
Neill, D. R., Wong, S. H., Bellosi, A., Flynn, R. J., Daly, M. G., Langford, T. K. A., Bucks, C. M., Kane, C. M., Fallon, P. G., Pannell, R., et al. (2010) · Nature · doi:10.1038/nature08900 · Cited by 2,079 · see citing works
Innate production of TH2 cytokines by adipose tissue-associated c-Kit+Sca-1+ lymphoid cells
Moro, K., Yamada, T., Tanabe, M., Takeuchi, T., Ikawa, T., Kawamoto, H., Furusawa, J.-I., Ohtani, M., Fujii, H., & Koyasu, S. (2009) · Nature · doi:10.1038/nature08636 · Cited by 1,994 · see citing works
Moussion, C., Ortega, N., & Girard, J.-P. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003331 · Cited by 1,179 · see citing works
Systemically dispersed innate IL-13–expressing cells in type 2 immunity
Price, A. E., Liang, H.-E., Sullivan, B. M., Reinhardt, R. L., Eisley, C. J., Erle, D. J., & Locksley, R. M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003988107 · Cited by 1,134 · see citing works
IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system
Sanada, S., Hakuno, D., Higgins, L., Schreiter, E. R., McKenzie, A. N. J., & Lee, R. T. (2007) · Journal of Clinical Investigation · doi:10.1172/jci30634 · Cited by 1,053 · see citing works
Carriere, V., Roussel, L., Ortega, N., Lacorre, D.-A., Americh, L., Aguilar, L., Bouche, G., & Girard, J.-P. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0606854104 · Cited by 966 · see citing works
IFN-gamma potentiates atherosclerosis in ApoE knock-out mice.
Gupta, S. K. S., Pablo, A. M., Jiang, X., Wang, N., Tall, A. R., & Schindler, C. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119465 · Cited by 863 · see citing works
Kurowska‐Stolarska, M., Stolarski, B., Kewin, P., Murphy, G., Corrigan, C. J., Ying, S., Pitman, N. I., Mirchandani, A. S., Rana, B. M. J., van Rooijen, N., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0901575 · Cited by 716 · see citing works
The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1
Cayrol, C., & Girard, J.-P. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0812690106 · Cited by 707 · see citing works
Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases
Lüthi, A. U., Cullen, S. P., McNeela, E. A., Duriez, P. J., Afonina, I. S., Sheridan, C., Brumatti, G., Taylor, R. C., Kersse, K., Vandenabeele, P., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.007 · Cited by 677 · see citing works
IL-33 is a crucial amplifier of innate rather than acquired immunity
Oboki, K., Ohno, T., Kajiwara, N., Arae, K., Morita, H., Ishii, A., Nambu, A., Abe, T., Kiyonari, H., Matsumoto, K., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1003059107 · Cited by 655 · see citing works
Weinberg, E. O., Shimpo, M., Keulenaer, G. W. D., MacGillivray, C., Tominaga, S., Solomon, S. D., Rouleau, J. L., & Lee, R. T. (2002) · Circulation · doi:10.1161/01.cir.0000038705.69871.d9 · Cited by 645 · see citing works
IL-33 reduces the development of atherosclerosis
Miller, A. M., Xu, D., Asquith, D. L., Denby, L., Li, Y., Sattar, N. A., Baker, A. H., McInnes, I. B., & Liew, F. Y. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20071868 · Cited by 642 · see citing works
Self-citationSmithgall, M. D., Comeau, M. R., Yoon, B. R., Kaufman, D., Armitage, R. J., & Smith, D. E. (2008) · International Immunology · doi:10.1093/intimm/dxn060 · Cited by 619 · see citing works
Löhning, M., Stroehmann, A., Coyle, A. J., Grogan, J. L., Lin, S., Gutierrez-Ramos, J.-C., Levinson, D. A., Radbruch, A., & Kamradt, T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.12.6930 · Cited by 606 · see citing works
Soluble ST2 Blocks Interleukin-33 Signaling in Allergic Airway Inflammation
Hayakawa, H., Hayakawa, M., Kume, A., & Tominaga, S. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m704916200 · Cited by 547 · see citing works
Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells
Préfontaine, D., Lajoie-Kadoch, S., Foley, S., Audusseau, S., Olivenstein, R., Halayko, A. J., Lemière, C., Martin, J. G., & Hamid, Q. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802387 · Cited by 538 · see citing works
Measurement of the Interleukin Family Member ST2 in Patients With Acute Dyspnea
Januzzi, J. L., Peacock, W. F., Maisel, A. S., Chae, C. U., Jesse, R. L., Baggish, A. L., O’Donoghue, M. L., Sakhuja, R., Chen‐Tournoux, A., van Kimmenade, R. R. J., et al. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.05.014 · Cited by 523 · see citing works
Cutting Edge: The ST2 Ligand IL-33 Potently Activates and Drives Maturation of Human Mast Cells
Allakhverdi, Z., Smith, D. E., Comeau, M. R., & Delespesse, G. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.4.2051 · Cited by 518 · see citing works
Selective Expression of a Stable Cell Surface Molecule on Type 2 but Not Type 1 Helper T Cells
Xu, D., Chan, W. L., Leung, B. P. L., Huang, F., Wheeler, R. D., Piedrafita, D. M., Robinson, J. H., & Liew, F. Y. (1998) · The Journal of Experimental Medicine · doi:10.1084/jem.187.5.787 · Cited by 512 · see citing works
IL-1 Receptor Accessory Protein and ST2 Comprise the IL-33 Receptor Complex
Chackerian, A. A., Oldham, E. R., Murphy, E. E., Schmitz, J., Pflanz, S., & Kastelein, R. A. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.179.4.2551 · Cited by 508 · see citing works
Identification of Serum Soluble ST2 Receptor as a Novel Heart Failure Biomarker
Weinberg, E. O., Shimpo, M., Hurwitz, S., Tominaga, S., Rouleau, J. L., & Lee, R. T. (2003) · Circulation · doi:10.1161/01.cir.0000047274.66749.fe · Cited by 504 · see citing works
A novel IL-1 family cytokine, IL-33, potently activates human eosinophils
Cherry, W. B., Yoon, J., Bartemes, K. R., Iijima, K., & Kita, H. (2008) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2008.04.005 · Cited by 499 · see citing works
Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection
Alves-Filho, J. C., Sônego, F., Souto, F. O., de Freitas, A., Verri, W. A., Jr., Auxiliadora‐Martins, M., Basile-Filho, A., McKenzie, A. N. J., Xu, D., Cunha, F. Q., et al. (2010) · Nature Medicine · doi:10.1038/nm.2156 · Cited by 487 · see citing works
Kondo, Y., Yoshimoto, T., Yasuda, K., Futatsugi‐Yumikura, S., Morimoto, M., Hayashi, N., Hoshino, T., Fujimoto, J., & Nakanishi, K. (2008) · International Immunology · doi:10.1093/intimm/dxn037 · Cited by 478 · see citing works
Bækkevold, E. S., Roussigné, M., Yamanaka, T., Johansen, F., Jahnsen, F. L., Amalric, F., Brandtzæg, P., Érard, M., Haraldsen, G., & Girard, J. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63631-0 · Cited by 474 · see citing works
IL-33 exacerbates antigen-induced arthritis by activating mast cells
Xu, D., Jiang, H., Kewin, P., Li, Y., Mu, R., Fraser, A. R., Pitman, N. I., Kurowska‐Stolarska, M., McKenzie, A. N. J., McInnes, I. B., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0801898105 · Cited by 465 · see citing works
Kurowska‐Stolarska, M., Kewin, P., Murphy, G., Russo, R. C., Stolarski, B., Garcia, C. C., Komai‐Koma, M., Pitman, N. I., Li, Y., McKenzie, A. N. J., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.7.4780 · Cited by 461 · see citing works
Increased IL-33 expression by epithelial cells in bronchial asthma
Préfontaine, D., Nadigel, J., Chouiali, F., Audusseau, S., Semlali, A., Chakir, J., Martin, J. G., & Hamid, Q. A. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.12.935 · Cited by 454 · see citing works
Davenport, P., & Tipping, P. G. (2003) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)63471-2 · Cited by 442 · see citing works
Pastorelli, L., Garg, R. R., Hoang, S. B., Spina, L., Mattioli, B., Scarpa, M., Fiocchi, C., Vecchi, M. L., & Pizarro, T. T. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0912678107 · Cited by 418 · see citing works
IL-33, a Potent Inducer of Adaptive Immunity to Intestinal Nematodes
Humphreys, N. E., Xu, D., Hepworth, M. R., Liew, F. Y., & Grencis, R. K. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.4.2443 · Cited by 417 · see citing works
Shimpo, M., Morrow, D. A., Weinberg, E. O., Sabatine, M. S., Murphy, S. A., Antman, E. M., & Lee, R. T. (2004) · Circulation · doi:10.1161/01.cir.0000127958.21003.5a · Cited by 410 · see citing works
IL-33–activated dendritic cells induce an atypical TH2-type response
Rank, M. A., Kobayashi, T., Kozaki, H., Bartemes, K. R., Squillace, D. L., & Kita, H. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.02.026 · Cited by 395 · see citing works
Characteristics of the Novel Interleukin Family Biomarker ST2 in Patients With Acute Heart Failure
Rehman, S., Mueller, T., & Januzzi, J. L. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.07.042 · Cited by 388 · see citing works
High-Sensitivity ST2 for Prediction of Adverse Outcomes in Chronic Heart Failure
Ky, B., French, B. C., McCloskey, K., Rame, J. E., McIntosh, E. E., Shahi, P., Dries, D. L., Tang, W. H. W., Wu, A. H. B., Fang, J. C.-T., et al. (2010) · Circulation Heart Failure · doi:10.1161/circheartfailure.110.958223 · Cited by 376 · see citing works
Coyle, A. J., Lloyd, C. M., Tian, J. Y., Nguyen, T. T. T., Erikkson, C., Wang, L., Ottoson, P., Persson, P. O., Delaney, T. A., Lehar, S. M., et al. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.7.895 · Cited by 370 · see citing works
IL-33 can promote survival, adhesion and cytokine production in human mast cells
Iikura, M., Suto, H., Kajiwara, N., Oboki, K., Ohno, T., Okayama, Y., Saito, H., Galli, S. J., & Nakae, S. (2007) · Laboratory Investigation · doi:10.1038/labinvest.3700663 · Cited by 370 · see citing works
Seki, K., Sanada, S., Kudinova, A. Y., Steinhauser, M. L., Handa, V., Gannon, J., & Lee, R. T. (2009) · Circulation Heart Failure · doi:10.1161/circheartfailure.109.873240 · Cited by 364 · see citing works
Ali, S., Huber, M., Kollewe, C., Bischoff, S. C., Falk, W., & Martin, M. U. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0705939104 · Cited by 325 · see citing works
Interleukin-33 Induces Protective Effects in Adipose Tissue Inflammation During Obesity in Mice
Miller, A. M., Asquith, D. L., Hueber, A. J., Anderson, L. A., Holmes, W. M., McKenzie, A. N. J., Xu, D., Sattar, N. A., McInnes, I. B., & Liew, F. Y. (2010) · Circulation Research · doi:10.1161/circresaha.110.218867 · Cited by 323 · see citing works
Self-citationTheoharides, T. C., Zhang, B., Kempuraj, D., Tagen, M., Vasiadi, M., Angelidou, A., Alysandratos, K., Kalogeromitros, D., Asadi, S., Stavrianeas, N. G., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000803107 · Cited by 320 · see citing works
IL‐33 is a chemoattractant for human Th2 cells
Komai‐Koma, M., Xu, D., Li, Y., McKenzie, A. N. J., McInnes, I. B., & Liew, F. Y. (2007) · European Journal of Immunology · doi:10.1002/eji.200737547 · Cited by 319 · see citing works
Sabatine, M. S., Morrow, D. A., Higgins, L., MacGillivray, C., Guo, W., Bode, C., Rifai, N., Cannon, C. P., Gerszten, R. E., & Lee, R. T. (2008) · Circulation · doi:10.1161/circulationaha.107.728022 · Cited by 315 · see citing works
Inhibition of interleukin‐33 signaling attenuates the severity of experimental arthritis
Palmer, G., Talabot‐Ayer, D., Lamacchia, C., Toy, D. Y., Seemayer, C. A., Viatte, S., Finckh, A., Smith, D. E., & Gabay, C. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24305 · Cited by 313 · see citing works
Interleukin-33 – cytokine of dual function or novel alarmin?
Haraldsen, G., Balogh, J., Pollheimer, J., Sponheim, J., & Küchler, A. M. (2009) · Trends in Immunology · doi:10.1016/j.it.2009.03.003 · Cited by 309 · see citing works
Choi, Y.-S., Choi, H.-J., Min, J., Pyun, B., Maeng, Y., Park, H., Kim, J., Kim, Y., & Kwon, Y. (2009) · Blood · doi:10.1182/blood-2009-02-203372 · Cited by 302 · see citing works
Roussel, L., Érard, M., Cayrol, C., & Girard, J. (2008) · EMBO Reports · doi:10.1038/embor.2008.145 · Cited by 300 · see citing works
IL-33 Exacerbates Eosinophil-Mediated Airway Inflammation
Stolarski, B., Kurowska‐Stolarska, M., Kewin, P., Xu, D., & Liew, F. Y. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000730 · Cited by 291 · see citing works
Weir, R. A. P., Miller, A. M., Murphy, G., Clements, S. E., Steedman, T., Connell, J., McInnes, I. B., Dargie, H. J., & McMurray, J. J. V. (2010) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.08.047 · Cited by 283 · see citing works
Self-citationIL-33 induces neutrophil migration in rheumatoid arthritis and is a target of anti-TNF therapy
Verri, W. A., Souto, F. O., Vieira, S. M., Almeida, S. C. L., Fukada, S. Y., Xu, D., Alves-Filho, J. C., Cunha, T. M., Guerrero, A. T. G., Mattos-Guimaraes, R. B., et al. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2009.122655 · Cited by 263 · see citing works
Interleukin-33 Is Biologically Active Independently of Caspase-1 Cleavage
Talabot‐Ayer, D., Lamacchia, C., Gabay, C., & Palmer, G. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m901744200 · Cited by 251 · see citing works
Interleukin-33 expression is specifically enhanced in inflamed mucosa of ulcerative colitis
Kobori, A., Yagi, Y., Imaeda, H., Ban, H., Bamba, S., Tsujikawa, T., Saito, Y., Fujiyama, Y., & Andoh, A. (2010) · Journal of Gastroenterology · doi:10.1007/s00535-010-0245-1 · Cited by 251 · see citing works
Kuhn, E. W., Addona, T. A., Keshishian, H., Burgess, M. W., Mani, D. R., Lee, R. T., Sabatine, M. S., Gerszten, R. E., & Carr, S. A. (2009) · Clinical Chemistry · doi:10.1373/clinchem.2009.123935 · Cited by 247 · see citing works
Bartúnek, J., Delrue, L., Durme, F. V., Müller, O., Casselman, F. P. A., Wiest, B. D., Croes, R., Verstreken, S., Goethals, M. A., RAEDT, H. D., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.09.027 · Cited by 244 · see citing works
Characterization of the novel ST2/IL-33 system in patients with inflammatory bowel disease
Beltrán, C. J., Núñez, L. E., Díaz-Jiménez, D., Farfán, N., Candía, E., Heine, C., López, F., González, M. J., Quera, R., & Hermoso, M. A. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21175 · Cited by 239 · see citing works
IL-33 Mediates Inflammatory Responses in Human Lung Tissue Cells
Yagami, A., Orihara, K., Morita, H., Futamura, K., Hashimoto, N., Matsumoto, K., Saito, H., & Matsuda, A. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903818 · Cited by 237 · see citing works
Pascual-Figal, D. A., Ordóñez‐Llanos, J., Tornel, P. L., Vázquez, R., Puig, T., Valdés, M., Juan Cinca, A., Bayés‐Genís, A., & Bayés‐Genís, A. (2009) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2009.07.041 · Cited by 233 · see citing works
Production and functions of IL-33 in the central nervous system
Yasuoka, S., Kawanokuchi, J., Parajuli, B., Jin, S., Doi, Y., Noda, M., Sonobe, Y., Takeuchi, H., Mizuno, T., & Suzumura, A. (2011) · Brain Research · doi:10.1016/j.brainres.2011.02.045 · Cited by 222 · see citing works
Küchler, A. M., Pollheimer, J., Balogh, J., Sponheim, J., Manley, L., Sørensen, D. R., Angelis, P. M. D., Scott, H., & Haraldsen, G. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.080014 · Cited by 220 · see citing works
Anti-IL-33 antibody treatment inhibits airway inflammation in a murine model of allergic asthma
Liu, X., Li, M., Wu, Y., Zhou, Y., Zeng, L., & Huang, T. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.06.008 · Cited by 218 · see citing works
IL-33 Induces IL-13–Dependent Cutaneous Fibrosis
Rankin, A. L., Mumm, J. B., Murphy, E., Turner, S. P., Yu, N., McClanahan, T. K., Bourne, P. A., Pierce, R. H., KASTELEIN, R. A., & Pflanz, S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0903306 · Cited by 217 · see citing works
Induction of IL-33 expression and activity in central nervous system glia
Hudson, C. A., Christophi, G. P., Gruber, R. C., Wilmore, J. R., Lawrence, D. A., & Massa, P. T. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.1207830 · Cited by 213 · see citing works
Serial Sampling of ST2 Predicts 90-Day Mortality Following Destabilized Heart Failure
Boisot, S., Beede, J., Isakson, S. R., Chiu, A., Clopton, P., Januzzi, J. L., Maisel, A. S., & Fitzgerald, R. L. (2008) · Journal of Cardiac Failure · doi:10.1016/j.cardfail.2008.06.415 · Cited by 210 · see citing works
Manzano‐Fernández, S., Mueller, T., Pascual-Figal, D. A., Truong, Q. A., & Januzzi, J. L. (2011) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2010.09.011 · Cited by 209 · see citing works
Transcriptomic and genetic studies identify IL-33 as a candidate gene for Alzheimer's disease
Chapuis, J., Hot, D., Hansmannel, F., Kerdraon, O., Ferreira, S., Hubans, C., Maurage, C. A., Huot, L., Bensemain, F., Laumet, G., et al. (2009) · Molecular Psychiatry · doi:10.1038/mp.2009.10 · Cited by 201 · see citing works
Hoshino, K., Kashiwamura, S., Kuribayashi, K., Kodama, T., Tsujimura, T., Nakanishi, K., Matsuyama, T., Takeda, K., & Akira, S. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.10.1541 · Cited by 201 · see citing works
IL-33 mediates antigen-induced cutaneous and articular hypernociception in mice
Verri, W. A., Jr., Guerrero, A. T. G., Fukada, S. Y., Valério, D. A. R., Cunha, T. M., Xu, D., Ferreira, S. H., Liew, F. Y., & Cunha, F. Q. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712116105 · Cited by 185 · see citing works
IL-33 Reduces Macrophage Foam Cell Formation
McLaren, J. E., Michael, D. R., Salter, R. C., Ashlin, T. G., Calder, C. J., Miller, A. M., Liew, F. Y., & Ramji, D. P. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000520 · Cited by 184 · see citing works
Self-citationIL-33, a recently identified interleukin-1 gene family member, is expressed in human adipocytes
Wood, I. S., Wang, B., & Trayhurn, P. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.04.081 · Cited by 183 · see citing works
Palmer, G., Lipsky, B. P., Smithgall, M. D., Meininger, D. P., Siu, S., Talabot‐Ayer, D., Gabay, C., & Smith, D. E. (2008) · Cytokine · doi:10.1016/j.cyto.2008.03.008 · Cited by 181 · see citing works
Shah, R. V., Chen‐Tournoux, A., Picard, M. H., van Kimmenade, R. R. J., & Januzzi, J. L. (2009) · Circulation Heart Failure · doi:10.1161/circheartfailure.108.833707 · Cited by 179 · see citing works
Mueller, T., Dieplinger, B., Gegenhuber, A., Poelz, W., Pacher, R., & Haltmayer, M. (2008) · Clinical Chemistry · doi:10.1373/clinchem.2007.096560 · Cited by 173 · see citing works
Mok, M. Y., Huang, F., Ip, W., Lo, Y., Wong, F. Y., Chan, E. Y. T., Lam, K. F., & Xu, D. (2009) · Lara D. Veeken · doi:10.1093/rheumatology/kep402 · Cited by 172 · see citing works
Matsuyama, Y., Okazaki, H., Tamemoto, H., KIMURA, H., Kamata, Y., Nagatani, K., Nagashima, T., Hayakawa, M., Iwamoto, M., Yoshio, T., et al. (2009) · The Journal of Rheumatology · doi:10.3899/jrheum.090492 · Cited by 169 · see citing works
Bulek, K., Swaidani, S., Qin, J., Lu, Y., Gulen, M. F., Herjan, T., Min, B., Kastelein, R. A., Aronica, M. A., Kosz‐Vnenchak, M., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802729 · Cited by 168 · see citing works
IL‐33 induces skin inflammation with mast cell and neutrophil activation
Hueber, A. J., Alves-Filho, J. C., Asquith, D. L., Michels, C., Millar, N. L., Reilly, J. H., Graham, G. J., Liew, F. Y., Miller, A. M., & McInnes, I. B. (2011) · European Journal of Immunology · doi:10.1002/eji.201041360 · Cited by 167 · see citing works
Self-citationOnda, H., Kasuya, H., Takakura, K., Hori, T., Imaizumi, T., Takeuchi, T., Inoue, I., & Takeda, J. (1999) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199911000-00013 · Cited by 165 · see citing works
Caspase-1, Caspase-8, and Calpain Are Dispensable for IL-33 Release by Macrophages
Ohno, T., Oboki, K., Kajiwara, N., Morii, E., Aozasa, K., Flavell, R. A., Okumura, K., Saito, H., & Nakae, S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802449 · Cited by 160 · see citing works
IL-33 family members and asthma – bridging innate and adaptive immune responses
Lloyd, C. M. (2010) · Current Opinion in Immunology · doi:10.1016/j.coi.2010.10.006 · Cited by 156 · see citing works
Espinassous, Q., Paco, E. G. D., García-Verdugo, I., Synguélakis, M., von Aulock, S., Sallenave, J., McKenzie, A. N. J., & Kanellopoulos, J. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803067 · Cited by 151 · see citing works
Sponheim, J., Pollheimer, J., Olsen, T., Balogh, J., Hammarström, C. L., Loos, T., Kasprzycka, M., Sørensen, D. R., Nilsen, H. R., Küchler, A. M., et al. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.100378 · Cited by 150 · see citing works
IL-33 is upregulated in colonocytes of ulcerative colitis
Seidelin, J. B., Bjerrum, J. T., Coskun, M., Widjaya, B., Vainer, B., & Nielsen, O. H. (2009) · Immunology Letters · doi:10.1016/j.imlet.2009.11.001 · Cited by 144 · see citing works
Schneider, E., Petit-Bertron, A.-F., Rignault‐Bricard, R., Levasseur, M., Ramadan, A., Girard, J., Herbelin, A., & Dy, M. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0900328 · Cited by 144 · see citing works
Schulze, J., Bickert, T., Beil, F. T., Zaiss, M. M., Albers, J., Wintges, K., Streichert, T., Klaetschke, K., Keller, J., Hißnauer, T.-N., et al. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.269 · Cited by 143 · see citing works
Yanaba, K., Yoshizaki, A., Asano, Y., Kadono, T., & Sato, S. (2011) · Clinical Rheumatology · doi:10.1007/s10067-011-1686-5 · Cited by 136 · see citing works
Louten, J., Rankin, A. L., Li, Y., Murphy, E. E., Beaumont, M., Moon, C., Bourne, P. A., McClanahan, T. K., Pflanz, S., & Malefyt, R. D. W. (2011) · International Immunology · doi:10.1093/intimm/dxr006 · Cited by 132 · see citing works
ST2 deletion enhances innate and acquired immunity to murine mammary carcinoma
Jovanović, I., Radosavljevic, G. D., Mitrović, M., Lisnić, V. J., McKenzie, A. N. J., Arsenijević, N., Jonjić, S., & Lukić, M. L. (2011) · European Journal of Immunology · doi:10.1002/eji.201141417 · Cited by 126 · see citing works
Jones, L. A., Roberts, F., Nickdel, M. B., Brombacher, F., McKenzie, A. N. J., Henriquez, F. L., Alexander, J. K., & Roberts, C. W. (2009) · European Journal of Immunology · doi:10.1002/eji.200939705 · Cited by 122 · see citing works
Tago, K., Noda, T., Hayakawa, M., Iwahana, H., Yanagisawa, K., Yashiro, T., & Tominaga, S. (2001) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2001.5306 · Cited by 121 · see citing works
IL-33 Exacerbates Autoantibody-Induced Arthritis
Xu, D., Jiang, H., Li, Y., Pushparaj, P. N., Kurowska‐Stolarska, M., Leung, B. P. L., Mu, R., Tay, H. K., McKenzie, A. N. J., McInnes, I. B., et al. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902685 · Cited by 119 · see citing works
Lamkanfi, M., & Dixit, V. M. (2009) · Immunity · doi:10.1016/j.immuni.2009.06.011 · Cited by 116 · see citing works
IL-33 Activates B1 Cells and Exacerbates Contact Sensitivity
Komai‐Koma, M., Gilchrist, D. S., McKenzie, A. N. J., Goodyear, C. S., Xu, D., & Liew, F. Y. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1002103 · Cited by 113 · see citing works
Association of ST2 Levels With Cardiac Structure and Function and Mortality in Outpatients
Daniels, L. B., Clopton, P., Iqbal, N., Tran, K., & Maisel, A. S. (2009) · American Heart Journal · doi:10.1016/j.ahj.2010.06.033 · Cited by 104 · see citing works
Bruno, R., Sabater, L., Sospedra, M., Ferrer-Francesch, X., Escudero, D., Martínez-Cáceres, E. M., & Pujol‐Borrell, R. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(2002010)32:10 · Cited by 102 · see citing works
Talabot‐Ayer, D., McKee, T., Gindre, P., Bas, S., Baeten, D., Gabay, C., & Palmer, G. (2011) · Joint Bone Spine · doi:10.1016/j.jbspin.2011.02.011 · Cited by 99 · see citing works
Interleukin-33 stimulates formation of functional osteoclasts from human CD14+ monocytes
Mun, S. H., Ko, N. Y., Kim, H. S., Kim, J. W., Kim, D. K., Kim, A., Lee, S. H., Kim, Y., Lee, C. K., Lee, S. H., et al. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0410-y · Cited by 96 · see citing works
Yang, Z., Liang, Y., Xi, W., Li, C., & Zhong, R. (2010) · Clinical and Experimental Medicine · doi:10.1007/s10238-010-0115-4 · Cited by 94 · see citing works
Tsuchiya, T., Ohshima, K., Karube, K., Yamaguchi, T., Suefuji, H., Hamasaki, M., Kawasaki, C., Suzumiya, J., Tomonaga, M., & Kikuchi, M. (2003) · Blood · doi:10.1182/blood-2002-05-1352 · Cited by 93 · see citing works
Rani, R., Smulian, A. G., Greaves, D. R., Hogan, S. P., & Herbert, D. R. (2011) · European Journal of Immunology · doi:10.1002/eji.201041135 · Cited by 89 · see citing works
Mu, R., Huang, H., Li, Y., Li, C., Ye, H., & Li, Z. (2010) · The Journal of Rheumatology · doi:10.3899/jrheum.100184 · Cited by 87 · see citing works
Over-expression of IL-33 leads to spontaneous pulmonary inflammation in mIL-33 transgenic mice
Zhiguang, X., Chen, W., Steven, R., Dong, W., Zhang, W., Mu, R., Zhanguo, L., & Zhang, L. (2010) · Immunology Letters · doi:10.1016/j.imlet.2010.04.005 · Cited by 85 · see citing works
Biomarkers of Heart Failure in Pleural Fluid
Porcel, J. M., Martínez‐Alonso, M., Cao, G., Bielsa, S., Sopena, A., & Esquerda, A. (2009) · CHEST Journal · doi:10.1378/chest.09-0270 · Cited by 79 · see citing works
Saleh, H., Eeles, D. G., Hodge, J. M., Nicholson, G. C., Gu, R., Pompolo, S., Gillespie, M. T., & Quinn, J. M. W. (2011) · Endocrinology · doi:10.1210/en.2010-1268 · Cited by 76 · see citing works
Identification of Constitutively Active Interleukin 33 (IL-33) Splice Variant
Hong, J., Bae, S., Jhun, H., Lee, S., Choi, J., Kang, T., Kwak, A., Hong, K., Kim, E., Jo, S., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.219089 · Cited by 74 · see citing works
Dieplinger, B., Gegenhuber, A., Kaar, G., Poelz, W., Haltmayer, M., & Mueller, T. (2010) · Clinical Biochemistry · doi:10.1016/j.clinbiochem.2010.02.002 · Cited by 73 · see citing works
Bayés‐Genís, A., Pascual-Figal, D. A., Januzzi, J. L., Maisel, A. S., Casas, T., Valdés, M., & Ordóñez‐Llanos, J. (2010) · Revista Española de Cardiología (English Edition) · doi:10.1016/s1885-5857(10)70231-0 · Cited by 69 · see citing works
T1/ST2 expression on Th2 cells negatively regulates allergic pulmonary inflammation
Mangan, N. E., Dasvarma, A., McKenzie, A. N. J., & Fallon, P. G. (2007) · European Journal of Immunology · doi:10.1002/eji.200636520 · Cited by 68 · see citing works
Bayés‐Genís, A., Pascual-Figal, D. A., Januzzi, J. L., Maisel, A. S., Casas, T., Chávarri, M. V., & Ordóñez‐Llanos, J. (2010) · Revista Española de Cardiología · doi:10.1016/s0300-8932(10)70249-9 · Cited by 65 · see citing works
IL-33 is expressed in human osteoblasts, but has no direct effect on bone remodeling
Saïdi, S., Bouri, F., Lencel, P., Duplomb, L., Baud’huin, M., Delplace, S., Leterme, D., Miellot, F., Heymann, D., Hardouin, P., et al. (2010) · Cytokine · doi:10.1016/j.cyto.2010.11.021 · Cited by 64 · see citing works
Rehman, S., Martinez‐Rumayor, A., Mueller, T., & Januzzi, J. L. (2008) · Clinica Chimica Acta · doi:10.1016/j.cca.2008.03.002 · Cited by 57 · see citing works
Implication of IL-33 gene polymorphism in Chinese patients with Alzheimer's disease
Yu, J.-T., Song, J.-H., Wang, N.-D., Wu, Z.-C., Zhang, Q., Zhang, N., Zhang, W., Xuan, S.-Y., & Tan, L. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2010.07.003 · Cited by 54 · see citing works
Martinez‐Rumayor, A., Camargo, C. A., Green, S. M., Baggish, A. L., O’Donoghue, M. L., & Januzzi, J. L. (2008) · American Journal of Clinical Pathology · doi:10.1309/wmg2bfrc97mkkqkp · Cited by 51 · see citing works
ST2 in Emergency Department Chest Pain Patients With Potential Acute Coronary Syndromes
Brown, A., Wu, A. H. B., Clopton, P., Robey, J. L., & Hollander, J. E. (2007) · Annals of Emergency Medicine · doi:10.1016/j.annemergmed.2007.02.015 · Cited by 40 · see citing works
Secretion of Soluble ST2 – Possible Explanation for Systemic Immunosuppression after Heart Surgery
Szerafin, T., Niederpold, T., Mangold, A., Höetzenecker, K., Hacker, S., Roth, G. A., Lichtenauer, M., Dworschak, M., Wolner, E., & Ankersmit, H. J. (2009) · The Thoracic and Cardiovascular Surgeon · doi:10.1055/s-2008-1039044 · Cited by 37 · see citing works
Kropf, P., Herath, S., Klemenz, R., & Müller, I. (2003) · Infection and Immunity · doi:10.1128/iai.71.4.1961-1971.2003 · Cited by 32 · see citing works
Modulation of interleukin signalling and gene expression in cardiac myocytes by endothelin-1
Yndestad, A., Marshall, A. K., Hodgkinson, J. D., Tham, E. L., Sugden, P. H., & Clerk, A. (2009) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2009.10.021 · Cited by 28 · see citing works
Yoshida, K., Arai, T., YOKOTA, T., Komatsu, N., Miura, Y., Yanagisawa, K., Tetsuka, T., & Tominaga, S. (1995) · Hybridoma · doi:10.1089/hyb.1995.14.419 · Cited by 24 · see citing works
Interleukins IL-33 and IL-17/IL-17A in patients with ulcerative colitis.
Ajdukovic, J., Tonkić, A., Salamunić, I., Hozo, I., Šimunić, M., & Bonacin, D. (2010) · PubMed · Cited by 20 · see citing works
Szerafin, T., Brunner, M., Horváth, A., Szentgyörgyi, L., Moser, B., Boltz‐Nitulescu, G., Péterffy, Á., Höetzenecker, K., Steinlechner, B., Wolner, E., et al. (2005) · PubMed · Cited by 19 · see citing works
Kalina (2002) · doi:10.1002/1521-4141(200209)32:9
Flagged first, then by citations
Cited by
Sorted by citations
Azevedo, R. S. S., de Sousa, J. R., Araujo, M. T. F., Martins Filho, A. J., de Alcantara, B. N., Araujo, F. M. C., Queiroz, M. G. L., Cruz, A. C. R., Vasconcelos, B. H. B., Chiang, J. O., et al. (2018) · Scientific Reports · doi:10.1038/s41598-017-17765-5 · Cited by 3,478 · see citing works
A role for IL-25 and IL-33–driven type-2 innate lymphoid cells in atopic dermatitis
Salimi, M., Barlow, J. L., Saunders, S. P., Xue, L., Gutowska‐Owsiak, D., Wang, X., Huang, L.-C., Johnson, D., Scanlon, S. T., McKenzie, A. N. J., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20130351 · Cited by 980 · see citing works
Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer
Alam, A., Levanduski, E., Denz, P. J., Villavicencio, H. S., Bhatta, M., Alhorebi, L., Zhang, Y., Gomez, E. C., Morreale, B. G., Senchanthisai, S., et al. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.01.003 · Cited by 374 · see citing works
Innate Lymphoid Cells in Inflammation and Immunity
McKenzie, A. N. J., Spits, H., & Eberl, G. (2014) · Immunity · doi:10.1016/j.immuni.2014.09.006 · Cited by 366 · see citing works
Fullerenes in biology and medicine
Castro, E., Garcia, A. H., Zavala, G., & Echegoyen, L. A. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb00855d · Cited by 366 · see citing works
Activated T Lymphocytes are Essential Drivers of Pathological Remodeling in Ischemic Heart Failure
Bansal, S. S., Ismahil, M. A., Goel, M., Patel, B., Hamid, T., Rokosh, G. D., & Prabhu, S. D. (2017) · Circulation Heart Failure · doi:10.1161/circheartfailure.116.003688 · Cited by 323 · see citing works
Computer-aided designing of immunosuppressive peptides based on IL-10 inducing potential
Nagpal, G., Usmani, S. S., Dhanda, S. K., Kaur, H., Singh, S., Sharma, D. M., & Raghava, G. P. S. (2017) · Scientific Reports · doi:10.1038/srep42851 · Cited by 318 · see citing works
Association of metabolic and inflammatory markers with polycystic ovarian syndrome (PCOS): an update
Gnanadass, S. A., Prabhu, Y. D., & Gopalakrishnan, A. V. (2021) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-020-05951-2 · Cited by 299 · see citing works
The role of cytokines in inflammatory bone loss
de Souza, P. C., & Lerner, U. H. (2013) · Immunological Investigations · doi:10.3109/08820139.2013.822766 · Cited by 272 · see citing works
Ballak, D. B., Stienstra, R., Tack, C. J., Dinarello, C. A., & van Diepen, J. A. (2015) · Cytokine · doi:10.1016/j.cyto.2015.05.005 · Cited by 256 · see citing works
Wooff, Y., Man, S. M., Aggio‐Bruce, R., Natoli, R., & Fernando, N. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01618 · Cited by 244 · see citing works
The translational revolution in atopic dermatitis: the paradigm shift from pathogenesis to treatment
Facheris, P., Jeffery, J., DUCA, E. D., & Guttman‐Yassky, E. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-00992-4 · Cited by 247 · see citing works
Bhat, A. A., Nisar, S., Singh, M. K., Ashraf, B., Masoodi, T., Prasad, C. P., Sharma, A., Maacha, S., Karedath, T., Hashem, S., et al. (2022) · 癌症：英文版 · doi:10.1002/cac2.12295 · Cited by 245 · see citing works
Salker, M. S., Nautiyal, J., Steel, J. H., Webster, Z., Šućurović, S., Nicou, M., Singh, Y., Lucas, E. S., Murakami, K., Chan, Y., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052252 · Cited by 223 · see citing works
Inflammation in acute and chronic pancreatitis
Habtezion, A. (2015) · Current Opinion in Gastroenterology · doi:10.1097/mog.0000000000000195 · Cited by 210 · see citing works
Kałużna, A., Olczyk, P., & Komosińska‐Vassev, K. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11020400 · Cited by 208 · see citing works
The role of IL‐33 and mast cells in allergy and inflammation
Saluja, R., Khan, M., Church, M. K., & Maurer, M. (2015) · Clinical and Translational Allergy · doi:10.1186/s13601-015-0076-5 · Cited by 199 · see citing works
IL-33 promotes the egress of group 2 innate lymphoid cells from the bone marrow
Stier, M. T., Zhang, J., Goleniewska, K., Cephus, J. Y., Rusznak, M., Wu, L., Kaer, L. V., Zhou, B., Newcomb, D. C., & Peebles, R. S. (2017) · The Journal of Experimental Medicine · doi:10.1084/jem.20170449 · Cited by 187 · see citing works
Kay, A. B., Clark, P., Maurer, M., & Ying, S. (2014) · British Journal of Dermatology · doi:10.1111/bjd.13621 · Cited by 170 · see citing works
New Cytokines in the Pathogenesis of Atopic Dermatitis—New Therapeutic Targets
Klonowska, J., Gleń, J., Nowicki, R. J., & Trzeciak, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103086 · Cited by 170 · see citing works
Demyanets, S., Kaun, C., Pentz, R., Krychtiuk, K. A., Rauscher, S., Pfaffenberger, S., Zuckermann, A. O., Aliabadi, A. Z., Gröger, M., Maurer, G., et al. (2013) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2013.03.020 · Cited by 165 · see citing works
Zeyda, M., Wernly, B., Demyanets, S., Kaun, C., Hämmerle, M., Hantusch, B., Schranz, M., Neuhofer, A., Itariu, B. K., Keck, M. K., et al. (2012) · International Journal of Obesity · doi:10.1038/ijo.2012.118 · Cited by 161 · see citing works
Saunders, S. P., Moran, T., Floudas, A., Wurlod, F., Kaszlikowska, A., Salimi, M., Quinn, E. M., Oliphant, C. J., Núñez, G., McManus, R., et al. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2015.06.045 · Cited by 160 · see citing works
IL-25 (IL-17E) in epithelial immunology and pathophysiology
Borowczyk, J., Shutova, M. S., Brembilla, N. C., & Boehncke, W. (2021) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2020.12.628 · Cited by 161 · see citing works
Shao, Y., Cheng, Z. A., Li, X., Chernaya, V., Wang, H., & Yang, X. (2014) · Journal of Hematology & Oncology · doi:10.1186/s13045-014-0080-6 · Cited by 155 · see citing works
Ryder, A. L., Azcarate, P. M., & Cohen, B. E. (2018) · Current Psychiatry Reports · doi:10.1007/s11920-018-0977-9 · Cited by 155 · see citing works
Zhang, Y., Davis, C., Shah, S. N., Hughes, D. T., Ryan, J. C., Altomare, D., & Peña, M. M. O. (2016) · Molecular Carcinogenesis · doi:10.1002/mc.22491 · Cited by 151 · see citing works
Alarmin IL-33 Acts as an Immunoadjuvant to Enhance Antigen-Specific Tumor Immunity
Villarreal, D. O., Wise, M. C., Walters, J. N., Reuschel, E. L., Choi, M. J., Obeng-Adjei, N., Yan, J., Morrow, M. P., & Weiner, D. B. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-2729 · Cited by 147 · see citing works
Teufelberger, A. R., Nordengrün, M., Braun, H., Maes, T., Grove, K. C. D., Holtappels, G., O'Brien, C., Provoost, S., Hammad, H., Gonçalves, A. C., et al. (2017) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2017.05.004 · Cited by 139 · see citing works
Type-2 Innate Lymphoid Cells in Asthma and Allergy
McKenzie, A. N. J. (2014) · Annals of the American Thoracic Society · doi:10.1513/annalsats.201403-097aw · Cited by 136 · see citing works
Role of interleukins in obesity: implications for metabolic disease
Febbraio, M. A. (2014) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2014.02.004 · Cited by 130 · see citing works
Liu, T., Kanaoka, Y., Barrett, N. A., Feng, C., Garofalo, D., Lai, J., Buchheit, K. M., Bhattacharya, N., Laidlaw, T. M., Katz, H. R., et al. (2015) · The Journal of Immunology · doi:10.4049/jimmunol.1500905 · Cited by 127 · see citing works
Luo, Y., Zhou, Y.-Q., Xiao, W., Liang, Z., Dai, J., Weng, X., & Wu, X. (2014) · Brain Research · doi:10.1016/j.brainres.2014.12.005 · Cited by 125 · see citing works
Common genetic variation at the IL1RL1 locus regulates IL-33/ST2 signaling
Ho, J. E., Chen, W., Chen, M., Larson, M. G., McCabe, E. L., Cheng, S. C., Ghorbani, A., Coglianese, E. E., Emilsson, V., Johnson, A. D., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67119 · Cited by 124 · see citing works
Alfonso‐Loeches, S., Ureña‐Peralta, J. R., Morillo-Bargues, M. J., Gómez‐Pinedo, U., & Guerri, C. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1760-5 · Cited by 122 · see citing works
Haridoss, M., Mohan, V., Deepa, M., Babu, S., & Aravindhan, V. (2014) · Cardiovascular Diabetology · doi:10.1186/1475-2840-13-1 · Cited by 118 · see citing works
Dieplinger, B., Egger, M., Haltmayer, M., Kleber, M. E., Scharnagl, H., Silbernagel, G., de Boer, R. A., Maerz, W., & Mueller, T. (2014) · Clinical Chemistry · doi:10.1373/clinchem.2013.209858 · Cited by 117 · see citing works
The role of interleukin-33 in chronic rhinosinusitis
Kim, D., Jin, H. R., Eun, K. M., Mo, J., Cho, S., Oh, S., Cho, D., & Kim, D. W. (2016) · Thorax · doi:10.1136/thoraxjnl-2016-208772 · Cited by 114 · see citing works
IL-1β suppresses innate IL-25 and IL-33 production and maintains helminth chronicity
Zaiss, M. M., Maslowski, K. M., Mosconi, I., Guenat, N., Marsland, B. J., & Harris, N. L. (2013) · PLoS Pathogens · doi:10.1371/journal.ppat.1003531 · Cited by 116 · see citing works
Interleukin-33 Is hepatoprotective during liver ischemia/reperfusion in mice
Sakai, N., Sweringen, H. L. V., Quillin, C. R., Schuster, R. M., Blanchard, J. A., Burns, J. M., Tevar, A. D., Edwards, M. J., & Lentsch, A. B. (2012) · Hepatology · doi:10.1002/hep.25768 · Cited by 109 · see citing works
Inflammasome Activation of IL‐1 Family Mediators in Response to Cutaneous Photodamage†
Nasti, T. H., & Timares, L. (2012) · Photochemistry and Photobiology · doi:10.1111/j.1751-1097.2012.01182.x · Cited by 106 · see citing works
Mast Cells Respond to Cell Injury through the Recognition of IL-33
Lunderius-Andersson, C., Enoksson, M., & Nilsson, G. P. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00082 · Cited by 106 · see citing works
Emerging role of interleukin‐33 in autoimmune diseases
Pei, C., Barbour, M., Fairlie‐Clarke, K. J., Allan, D., Mu, R., & Jiang, H. (2013) · Immunology · doi:10.1111/imm.12174 · Cited by 106 · see citing works
IL-33/IL-31 Axis: A Potential Inflammatory Pathway
Salvo, E. D., Ventura-Spagnolo, E., Casciaro, M., Navarra, M., & Gangemi, S. (2018) · Mediators of Inflammation · doi:10.1155/2018/3858032 · Cited by 105 · see citing works
Dual role of lipoproteins in endothelial cell dysfunction in atherosclerosis
Stancu, C. S., Toma, L., & Sima, A. V. (2012) · Cell and Tissue Research · doi:10.1007/s00441-012-1437-1 · Cited by 104 · see citing works
Buckley, M. L., & Ramji, D. P. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2015.04.011 · Cited by 98 · see citing works
The Pro-tumorigenic IL-33 Involved in Antitumor Immunity: A Yin and Yang Cytokine
Fournié, J., & Poupot, M. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02506 · Cited by 97 · see citing works
Demyanets, S., Speidl, W. S., Tentzeris, I., Járai, R., Katsaros, K. M., Farhan, S., Krychtiuk, K. A., Wonnerth, A., Weiss, T. W., Huber, K., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0095055 · Cited by 96 · see citing works
Oxidised IL-33 drives COPD epithelial pathogenesisviaST2-independent RAGE/EGFR signalling complex
Strickson, S., Houslay, K. F., Negri, V. A., Ohne, Y., Ottosson, T., Dodd, R. B., Chaillan, C., Baker, T., Li, J., Stephenson, K. E., et al. (2023) · European Respiratory Journal · doi:10.1183/13993003.02210-2022 · Cited by 95 · see citing works
Andrés‐Benito, P., Moreno, J. R., Aso, E., Povedano, M., & Ferrer, I. (2017) · Aging · doi:10.18632/aging.101195 · Cited by 89 · see citing works
Interleukin 33: a switch-hitting cytokine
Villarreal, D. O., & Weiner, D. B. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.03.004 · Cited by 93 · see citing works
Stojković, S., Kaun, C., Basílio, J., Rauscher, S., Hell, L., Krychtiuk, K. A., Bonstingl, C., de Martin, R., Gröger, M., Ay, C., et al. (2016) · Scientific Reports · doi:10.1038/srep25171 · Cited by 87 · see citing works
Endothelium-mediated contributions to fibrosis
Sun, X., Nkennor, B., Mastikhina, O., Soon, K., & Nunes, S. S. (2019) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2019.10.015 · Cited by 88 · see citing works
IL-33/ST2 axis in autoimmune disease
Shakerian, L., Kolahdooz, H., Garousi, M. T., Keyvani, V., Kheder, R. K., Faraj, T. A., Yazdanpanah, E., & Esmaeili, S. (2022) · Cytokine · doi:10.1016/j.cyto.2022.156015 · Cited by 85 · see citing works
The Role of IL-33-Dependent Inflammation in the Tumor Microenvironment
Wasmer, M.-H., & Krebs, P. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00682 · Cited by 84 · see citing works
Abbott, R. D., Wang, R. Y., Reagan, M. R., Chen, Y. G., Borowsky, F. E., Zieba, A., Marra, K. G., Rubin, J. P., Ghobrial, I. M., & Kaplan, D. L. (2016) · Advanced Healthcare Materials · doi:10.1002/adhm.201600211 · Cited by 81 · see citing works
Special aspects of interleukin-33 and the IL-33 receptor complex
Martin, M. U. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.10.006 · Cited by 80 · see citing works
Cytokine Signaling in the Development and Homeostasis of Regulatory T cellsPreprint
Toomer, K. H., & Malek, T. R. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a028597 · Cited by 79 · see citing works
Insights into Group 2 Innate Lymphoid Cells in Human Airway Disease
Karta, M. R., Broide, D. H., & Doherty, T. A. (2016) · Current Allergy and Asthma Reports · doi:10.1007/s11882-015-0581-6 · Cited by 77 · see citing works
Schmieder, A., Multhoff, G., & Radons, J. (2012) · Cytokine · doi:10.1016/j.cyto.2012.06.286 · Cited by 77 · see citing works
Tetè, S., Tripodi, D., Rosati, M., Conti, F., Maccauro, G., Saggini, A., Cianchetti, E., Caraffa, A., Antinolfi, P., Toniato, E., et al. (2012) · International Journal of Immunopathology and Pharmacology · doi:10.1177/039463201202500105 · Cited by 75 · see citing works
Glück, J., Rymarczyk, B., & Rogala, B. (2012) · Inflammation Research · doi:10.1007/s00011-012-0443-9 · Cited by 73 · see citing works
Immunomodulation and Immune Escape Strategies of Gastrointestinal Helminths and Schistosomes
Wiedemann, M., & Voehringer, D. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.572865 · Cited by 75 · see citing works
IL-33 biology in cancer: An update and future perspectives.
Yeoh, W. J., Vu, V., & Krebs, P. (2022) · Cytokine · doi:10.1016/j.cyto.2022.155961 · Cited by 62 · see citing works
Connelly, C. E., Sun, Y., & Carbonetti, N. H. (2012) · Infection and Immunity · doi:10.1128/iai.00808-12 · Cited by 71 · see citing works
Interleukin-1 family cytokines and their regulatory proteins in normal pregnancy and pre-eclampsia
Southcombe, J. H., Redman, C. W. G., Sargent, I. L., & Granne, I. (2015) · Clinical & Experimental Immunology · doi:10.1111/cei.12608 · Cited by 71 · see citing works
IL-33 Induces Nuocytes and Modulates Liver Injury in Viral Hepatitis
Liang, Y., Jie, Z., Hou, L., Aguilar‐Valenzuela, R., Vu, D., Soong, L., & Sun, J. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1300117 · Cited by 70 · see citing works
Kempuraj, D., Twait, E. C., Williard, D. E., Yuan, Z., Meyerholz, D. K., & Samuel, I. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056866 · Cited by 70 · see citing works
The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19
Makaremi, S., Asgarzadeh, A., Kianfar, H., Mohammadnia, A., Asghariazar, V., & Safarzadeh, E. (2022) · Inflammation Research · doi:10.1007/s00011-022-01596-w · Cited by 68 · see citing works
IL-33 (Interleukin 33)/sST2 Axis in Hypertension and Heart Failure
Ghali, R., Altara, R., Louch, W. E., Cataliotti, A., Mallat, Z., Kaplan, A., Zouein, F. A., & Booz, G. W. (2018) · Hypertension · doi:10.1161/hypertensionaha.118.11157 · Cited by 67 · see citing works
Evidence for a regulatory loop between IFN‐γ and IL‐33 in skin inflammation
Seltmann, J., Werfel, T., & Wittmann, M. (2012) · Experimental Dermatology · doi:10.1111/exd.12076 · Cited by 67 · see citing works
IL-33/IL-31 Axis in Osteoporosis
Martinis, M. D., Sirufo, M. M., Suppa, M., & Ginaldi, L. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21041239 · Cited by 68 · see citing works
Fousteris, E., Melidonis, A., Panoutsopoulos, G. I., Tzirogiannis, K. N., Foussas, S. G., Theodosis-Georgilas, A., Tzerefos, S., Matsagos, S., Boutati, E. I., Economopoulos, T., et al. (2011) · Cardiovascular Diabetology · doi:10.1186/1475-2840-10-101 · Cited by 66 · see citing works
Ishikawa, K., Yagi-Nakanishi, S., Nakanishi, Y., Kondo, S., Tsuji, A., Endo, K., Wakisaka, N., Murono, S., & Yoshizaki, T. (2014) · Auris Nasus Larynx · doi:10.1016/j.anl.2014.08.007 · Cited by 66 · see citing works
Pathophysiology of IL-33 and IL-17 in allergic disorders
Gupta, R. K., Gupta, K., & Dwivedi, P. D. (2017) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2017.09.005 · Cited by 66 · see citing works
Serum IL-33 Is a Novel Diagnostic and Prognostic Biomarker in Acute Ischemic Stroke
Li, Q., Yuanshao, L., Huang, W., Zhou, Y., Xiaoli, C., Wang, B. Z., Wanli, Z., Zhengyi, C., Jie, X., Wenhui, Z., et al. (2016) · Aging and Disease · doi:10.14336/ad.2016.0207 · Cited by 64 · see citing works
Neural Stem Cell-Conditioned Medium Suppresses Inflammation and Promotes Spinal Cord Injury Recovery
Cheng, Z., Bosco, D. B., Sun, L. J., Chen, X., Xu, Y., Tai, W., Didier, R., Li, J., Fan, J., He, X., et al. (2016) · Cell Transplantation · doi:10.3727/096368916x693473 · Cited by 63 · see citing works
Challenging the Paradigm: Anti-Inflammatory Interleukins and Angiogenesis
Peluzzo, A. M., & Autieri, M. V. (2022) · Cells · doi:10.3390/cells11030587 · Cited by 64 · see citing works
Current insights into the role of human β-defensins in atopic dermatitis
Chieosilapatham, P., Ogawa, H., & Niyonsaba, F. (2017) · Clinical & Experimental Immunology · doi:10.1111/cei.13013 · Cited by 62 · see citing works
Verheijden, K. A. T., Willemsen, L. E. M., Braber, S., Leusink-Muis, T., Delsing, D. J. M., Garssen, J., Kraneveld, A. D., & Folkerts, G. (2015) · Respiratory Research · doi:10.1186/s12931-015-0171-0 · Cited by 61 · see citing works
IL-33 enhances macrophage M2 polarization and protects mice from CVB3-induced viral myocarditis
Wang, C., Dong, C., & Xiong, S. (2016) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2016.12.010 · Cited by 60 · see citing works
Akimoto, M., Hayashi, J.-I., Nakae, S., Saito, H., & Takenaga, K. (2016) · Cell Death and Disease · doi:10.1038/cddis.2015.418 · Cited by 59 · see citing works
Cell–Cell Interaction Mechanisms in Acute Lung Injury
Zhou, H., Fan, E. K., & Fan, J. (2020) · Shock · doi:10.1097/shk.0000000000001598 · Cited by 58 · see citing works
Jones‐Hall, Y., & Grisham, M. B. (2014) · Pathophysiology · doi:10.1016/j.pathophys.2014.05.002 · Cited by 57 · see citing works
Asahina, R., & Maeda, S. (2017) · Veterinary dermatology (Print) · doi:10.1111/vde.12351 · Cited by 57 · see citing works
Cytokines and the immune response in obesity-related disorders
Moghbeli, M., Khedmatgozar, H., Yadegari, M., Avan, A., Ferns, G. A., & Mobarhan, M. G. (2020) · Advances in clinical chemistry · doi:10.1016/bs.acc.2020.06.004 · Cited by 57 · see citing works
Sex differences and immune correlates of Long Covid development, symptom persistence, and resolution
Hamlin, R. E., Pienkos, S. M., Chan, L., Stabile, M. A., Pinedo, K., Rao, M., Grant, P., Bonilla, H. F., Holubar, M. K., Singh, U., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adr1032 · Cited by 59 · see citing works
Spinal interleukin-33 and its receptor ST2 contribute to bone cancer-induced pain in mice
Zhao, J., Zhang, H., Liu, S.-B., Han, P., Hu, S., Li, Q., Wang, Z.-F., Mao‐Ying, Q., Chen, H.-M., Jiang, J., et al. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.08.026 · Cited by 55 · see citing works
Rivas, M. N., Koh, Y. T., Chen, A., Nguyen, A. L., Lee, Y., Lawson, G., & Chatila, T. A. (2012) · Journal of Clinical Investigation · doi:10.1172/jci40591 · Cited by 55 · see citing works
Interleukin-33 serum levels in postmenopausal women with osteoporosis
Ginaldi, L., Martinis, M. D., Saitta, S., Sirufo, M. M., Mannucci, C., Casciaro, M., Ciccarelli, F., & Gangemi, S. (2019) · Scientific Reports · doi:10.1038/s41598-019-40212-6 · Cited by 54 · see citing works
He, X., Bai, Y., Zhou, H., & Wu, K. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.906920 · Cited by 54 · see citing works
Interleukin‐33 induces urokinase in human endothelial cells―possible impact on angiogenesis
Stojković, S., Kaun, C., Heinz, M., Krychtiuk, K. A., Rauscher, S., Lemberger, C. E., de Martin, R., Gröger, M., Petzelbauer, P., Huk, I., et al. (2014) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12581 · Cited by 54 · see citing works
Stromal and immune cells in gut fibrosis: the myofibroblast and the scarface
Valatas, V. (2017) · Annals of Gastroenterology · doi:10.20524/aog.2017.0146 · Cited by 55 · see citing works
IL-33 and Its Receptor ST2 after Inhaled Allergen Challenge in Allergic Asthmatics
Mitchell, P. D., Salter, B., Oliveria, J. P., El-Gammal, A. I., Tworek, D., Smith, S. G., Sehmi, R., Gauvreau, G. M., & O’Byrne, P. M. (2018) · International Archives of Allergy and Immunology · doi:10.1159/000488015 · Cited by 54 · see citing works
Alarmins in Osteoporosis, RAGE, IL-1, and IL-33 Pathways: A Literature Review
Martinis, M. D., Ginaldi, L., Sirufo, M. M., Pioggia, G., Calapai, G., Gangemi, S., & Mannucci, C. (2020) · Medicina · doi:10.3390/medicina56030138 · Cited by 53 · see citing works
Kaur, G., Sharma, D., Bisen, S., Mukhopadhyay, C. S., Gurdziel, K., & Singh, N. K. (2023) · Communications Biology · doi:10.1038/s42003-023-04905-z · Cited by 52 · see citing works
Helicobacter pylori vs coronary heart disease - searching for connections
Chmiela, M., Gajewski, A., & Rudnicka, K. (2015) · World Journal of Cardiology · doi:10.4330/wjc.v7.i4.187 · Cited by 51 · see citing works
The Role of IL-33/ST2 in COPD and Its Future as an Antibody Therapy
Riera, L., Cànaves‐Gómez, L., Iglesias, A., Martín-Medina, A., & Cosío, B. G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24108702 · Cited by 50 · see citing works
Transgenic over-expression of interleukin-33 in osteoblasts results in decreased osteoclastogenesis
Keller, J., Catalá-Lehnen, P., Wintges, K., Schulze, J., Bickert, T., Ito, W. D., Horst, A. K., Amling, M., & Schinke, T. (2011) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2011.11.088 · Cited by 50 · see citing works
The potential role of IL-33/ST2 signaling in fibrotic diseases
Gao, Q., Li, Y., & Li, M. (2015) · Journal of Leukocyte Biology · doi:10.1189/jlb.3ru0115-012r · Cited by 50 · see citing works
- Authors
- Miller, A. M.
- Affiliations
- University of Glasgow (GB)
- Corresponding author
- Miller, Ashley M
- ORCID
- Miller, Ashley M
- Venue
- Journal of Inflammation
- Published
- 2011
- Volume
- 8
- Issue
- 1
- Pages
- 22
- ISSN
- 1476-9255 (ISSN-L)
- PMC
- PMC3175149
- OpenAlex
- W2137520462
- Cited by
- 481
- References
- 124
- Citations by year
- 2026: 18 · 2025: 21 · 2024: 27 · 2023: 39 · 2022: 27 · 2021: 32 · 2020: 37 · 2019: 31 · 2018: 28 · 2017: 48 · 2016: 40 · 2015: 42 · 2014: 33 · 2013: 27 · 2012: 25
- FWCI
- 12.77
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- cc-by
- Locations
- Journal of Inflammation (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- British Heart Foundation (FS/08/035/25309)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Health Sciences › Medicine › Oncology › Cytokine Signaling Pathways and Interactions
- Life Sciences › Immunology and Microbiology › Immunology › Mast cells and histamine
- Keywords
- IL-33, IL-1 superfamily, IL-1 receptor accessory protein, alarmins, Th2 cells, asthma, atopic dermatitis, anaphylaxis, atherosclerosis, obesity, type 2 diabetes, cardiac remodeling, inflammation, innate immunity
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
