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Microglial activation in healthy aging
Abstract
Healthy brain aging is characterized by neuronal loss and decline of cognitive function. Neuronal loss is closely associated with microglial activation and postmortem studies have indeed suggested that activated microglia may be present in the aging brain. Microglial activation can be quantified in vivo using (R)-[(11)C]PK11195 and positron emission tomography. The purpose of this study was to measure specific binding of (R)-[(11)C]PK11195 in healthy subjects over a wide age range. Thirty-five healthy subjects (age range 19-79 years) were included. In all subjects 60-minute dynamic (R)-[(11)C]PK11195 scans were acquired. Specific binding of (R)-[(11)C]PK11195 was calculated using receptor parametric mapping in combination with supervised cluster analysis to extract the reference tissue input function. Increased binding of (R)-[(11)C]PK11195 with aging was found in frontal lobe, anterior and posterior cingulate cortex, medial inferior temporal lobe, insula, hippocampus, entorhinal cortex, thalamus, parietal and occipital lobes, and cerebellum. This indicates that activated microglia appear in several cortical and subcortical areas during healthy aging, suggesting widespread neuronal loss.
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“Several PET scan studies have revealed increased receptor binding of the TSPO ligands, R-[ 11 C]PK11195 and [ 11 C]vinpocetine, in the cortical and subcortical brain regions of healthy elderly participants (Gulyas et al, 2011;Schuitemaker et al, 2012).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Schuitemaker et al, 2012
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Metadata
- Authors
- Schuitemaker, A., van der Doef, T. F., Boellaard, R., van der Flier, W. M., Yaqub, M., Windhorst, A. D., Barkhof, F., Jonker, C., Kloet, R. W., Lammertsma, A. A., Scheltens, P., & van Berckel, B. N. M.
- Affiliations
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Corresponding author
- Schuitemaker, Alie
- ORCID
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2012-06
- Volume
- 33
- Issue
- 6
- Pages
- 1067-1072
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2009391988
- Cited by
- 142
- References
- 35
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 5 · 2023: 4 · 2022: 9 · 2021: 11 · 2020: 7 · 2019: 17 · 2018: 12 · 2017: 9 · 2016: 15 · 2015: 10 · 2014: 5 · 2013: 10 · 2012: 11
- FWCI
- 4.76
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- VU Research Portal (publishedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- UCL Discovery (University College London) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- European Commission
- Vrije Universiteit Amsterdam
- National Cancer Institute
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- microglial activation, healthy brain aging, neuronal loss, cognitive decline
- MeSH terms
- Adult, Aged, Aging, Brain, Female, Humans, Isoquinolines, Male, Middle Aged, Protein Binding, Cellular Senescence, Microglia, Young Adult
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