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Cited by 142Neuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and TreatmentsDementia and Cognitive Impairment Research

The DOI matches its Crossref record; 34 of the 35 references it cites were found in a registry or an index.

Microglial activation in healthy aging

Schuitemaker, Alie, van der Doef, Thalia F., Boellaard, Ronald, van der Flier, Wiesje M., Yaqub, Maqsood, Windhorst, Albert D., Barkhof, Frederik, Jonker, Cees, Kloet, Reina W., Lammertsma, Adriaan A., Scheltens, Philip, van Berckel, Bart N.M.·2012·Neurobiology of Aging
DOI 10.1016/j.neurobiolaging.2010.09.016
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Abstract

Healthy brain aging is characterized by neuronal loss and decline of cognitive function. Neuronal loss is closely associated with microglial activation and postmortem studies have indeed suggested that activated microglia may be present in the aging brain. Microglial activation can be quantified in vivo using (R)-[(11)C]PK11195 and positron emission tomography. The purpose of this study was to measure specific binding of (R)-[(11)C]PK11195 in healthy subjects over a wide age range. Thirty-five healthy subjects (age range 19-79 years) were included. In all subjects 60-minute dynamic (R)-[(11)C]PK11195 scans were acquired. Specific binding of (R)-[(11)C]PK11195 was calculated using receptor parametric mapping in combination with supervised cluster analysis to extract the reference tissue input function. Increased binding of (R)-[(11)C]PK11195 with aging was found in frontal lobe, anterior and posterior cingulate cortex, medial inferior temporal lobe, insula, hippocampus, entorhinal cortex, thalamus, parietal and occipital lobes, and cerebellum. This indicates that activated microglia appear in several cortical and subcortical areas during healthy aging, suggesting widespread neuronal loss.

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Crossref · 10.1016/j.neurobiolaging.2010.09.016

Cites

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Citations

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Research works printed but not linked: 2

  1. Boellaard, 2008, Performance of a modified supervised cluster algorithm for extracting reference tissue input functions from (R)-[11C]PK11195 PET studies, IEEE Medical Imaging Conference Program Edition, 2008, 209
  2. Brix, 1997, Performance evaluation of a whole-body PET scanner using the NEMA protocol, J. Nucl. Med, 38, 1614

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Metadata

Authors
Schuitemaker, A., van der Doef, T. F., Boellaard, R., van der Flier, W. M., Yaqub, M., Windhorst, A. D., Barkhof, F., Jonker, C., Kloet, R. W., Lammertsma, A. A., Scheltens, P., & van Berckel, B. N. M.
Affiliations
Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
Corresponding author
Schuitemaker, Alie
ORCID
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2012-06
Volume
33
Issue
6
Pages
1067-1072
ISSN
0197-4580 (ISSN-L)
DOI
10.1016/j.neurobiolaging.2010.09.016
OpenAlex
W2009391988
Cited by
142
References
35
Citations by year
2026: 4 · 2025: 9 · 2024: 5 · 2023: 4 · 2022: 9 · 2021: 11 · 2020: 7 · 2019: 17 · 2018: 12 · 2017: 9 · 2016: 15 · 2015: 10 · 2014: 5 · 2013: 10 · 2012: 11
FWCI
4.76
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Neurobiology of Aging (publishedVersion)
  • PubMed (publishedVersion)
  • Pure Amsterdam UMC (publishedVersion)
  • Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
  • VU Research Portal (publishedVersion)
  • Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
  • UCL Discovery (University College London) (submittedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
Funders
  • European Commission
  • Vrije Universiteit Amsterdam
  • National Cancer Institute
Topics
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
  • Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Keywords
microglial activation, healthy brain aging, neuronal loss, cognitive decline
MeSH terms
Adult, Aged, Aging, Brain, Female, Humans, Isoquinolines, Male, Middle Aged, Protein Binding, Cellular Senescence, Microglia, Young Adult

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