Higher iron in the red nucleus marks Parkinson's dyskinesia
Open accessAbstract
Dopamine cell loss and increased iron in the substantia nigra (SN) characterize Parkinson's disease (PD), with cerebellar involvement increasingly recognized, particularly in motor compensation and levodopa-induced dyskinesia (LID) development. Because the red nucleus (RN) mediates cerebellar circuitry, we hypothesized that RN iron changes might reflect cerebellum-related compensation, and/or the intrinsic capacity for LID development. We acquired high resolution magnetic resonance images from 23 control and 38 PD subjects (12 with PD and history of LID [PD+DYS]) and 26 with PD and no history of LID (PD-DYS). Iron content was estimated from bilateral RN and SN transverse relaxation rates (R2*). PD subjects overall displayed higher R2* values in both the SN and RN. RN R2* values correlated with off-drug Unified Parkinson's Disease Rating Scale-motor scores, but not disease duration or drug dosage. RN R2* values were significantly higher in PD+DYS compared with control and PD-DYS subjects; control and PD-DYS subjects did not differ. The association of higher RN iron content with PD-related dyskinesia suggests increased iron content is involved in, or reflects, greater cerebellar compensatory capacity and thus increased likelihood of LID development.
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Increased total iron content, detected by MRI, was reported in the red nuclei of patients with Parkinson's disease and dyskinesia.
“Increased total iron content, detected by MRI, was reported in the red nuclei of patients with Parkinson’s disease and dyskinesia.129”
From The role of iron in brain ageing and neurodegenerative disorders (2014) · cites this paper as [129]
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The role of iron in brain ageing and neurodegenerative disorders
Ward, R. J., Zucca, F. A., Duyn, J. H., Crichton, R. R., & Zecca, L. (2014) · The Lancet Neurology · doi:10.1016/s1474-4422(14)70117-6 · Cited by 1,819 · see citing works
- Authors
- Lewis, M. M., Du, G., Kidacki, M., Patel, N., Shaffer, M. L., Mailman, R. B., & Huang, X.
- Affiliations
- Pennsylvania State University (US)
- Corresponding author
- Huang, Xuemei
- ORCID
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 34
- Issue
- 5
- Pages
- 1497-1503
- ISSN
- 0197-4580 (ISSN-L)
- PMC
- PMC3570638
- OpenAlex
- W1979023529
- Cited by
- 84
- References
- 47
- Citations by year
- 2026: 4 · 2025: 1 · 2024: 6 · 2023: 6 · 2022: 13 · 2021: 12 · 2020: 7 · 2019: 2 · 2018: 5 · 2017: 8 · 2016: 6 · 2015: 5 · 2014: 6 · 2013: 3
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (NS060722, NS082151, ES019672 to XH)
- Penn State Clinical and Translational Science Institute, Pennsylvania State University CTSA (UL-1RR033184)
- Pennsylvania Department of Health Tobacco Settlement Funds (C06 RR016499)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Medicine › Neurology › Neurological disorders and treatments
- Keywords
- Parkinson's disease, levodopa-induced dyskinesia, red nucleus, iron accumulation, substantia nigra, R2* relaxation rate, motor symptoms
- MeSH terms
- Female, Humans, Iron, Magnetic Resonance Imaging, Male, Middle Aged, Parkinson Disease, Red Nucleus, Tissue Distribution, Biomarkers
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