Measurements of medial temporal lobe atrophy for prediction of Alzheimer's disease in subjects with mild cognitive impairment
Open accessAbstract
Our aim was to compare the predictive accuracy of 4 different medial temporal lobe measurements for Alzheimer's disease (AD) in subjects with mild cognitive impairment (MCI). Manual hippocampal measurement, automated atlas-based hippocampal measurement, a visual rating scale (MTA-score), and lateral ventricle measurement were compared. Predictive accuracy for AD 2 years after baseline was assessed by receiver operating characteristics analyses with area under the curve as outcome. Annual cognitive decline was assessed by slope analyses up to 5 years after baseline. Correlations with biomarkers in cerebrospinal fluid (CSF) were investigated. Subjects with MCI were selected from the Development of Screening Guidelines and Clinical Criteria for Predementia AD (DESCRIPA) multicenter study (n = 156) and the single-center VU medical center (n = 172). At follow-up, area under the curve was highest for automated atlas-based hippocampal measurement (0.71) and manual hippocampal measurement (0.71), and lower for MTA-score (0.65) and lateral ventricle (0.60). Slope analysis yielded similar results. Hippocampal measurements correlated with CSF total tau and phosphorylated tau, not with beta-amyloid 1-42. MTA-score and lateral ventricle volume correlated with CSF beta-amyloid 1-42. We can conclude that volumetric hippocampal measurements are the best predictors of AD conversion in subjects with MCI.
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Medial temporal lobe atrophy on MRI is considered an early and sensitive marker for AD, and is assumed to reflect underlying neuronal loss in hippocampus and temporal lobe.
“Medial temporal lobe (MTA) atrophy as observed on MRI is considered to be an early and sensitive marker for AD, and is assumed that it reflects underlying neuronal loss in hippocampus and temporal lobe (Clerx et al., 2013; Jack et al., 1997; Duara et al., 2008).”
From T1rho MRI and CSF biomarkers in diagnosis of Alzheimer's disease (2015) · cites this paper as Clerx et al., 2013
The Introduction describes MRI-assessed medial temporal lobe atrophy as an effective aid to early AD diagnosis, and §4.1.1 calls medial temporal neurodegeneration a strong MRI marker of imminent conversion. The paper does not state that the MRI finding reflects neuronal loss in the hippocampus and temporal lobe; §4.1.3 notes that some atrophy measures may reflect more generalized atrophy. (LLM, conf=0.84)
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- Authors
- Clerx, L., van Rossum, I. A., Burns, L., Knol, D. L., Scheltens, P., Verhey, F., Aalten, P., Lapuerta, P., van de Pol, L., van Schijndel, R., de Jong, R., Barkhof, F., Wolz, R., Rueckert, D., Bocchetta, M., Tsolaki, M., Nobili, F., Wahlund, L.-O., Minthon, L., Frölich, L., Hampel, H., Soininen, H., & Visser, P. J.
- Affiliations
- Maastricht University (NL)
- Bristol-Myers Squibb (United States) (US)
- Amsterdam UMC Location Vrije Universiteit Amsterdam (NL)
- Lexicon Pharmaceuticals (United States) (US)
- Imperial College London (GB)
- Centro San Giovanni di Dio Fatebenefratelli (IT)
- University of Genoa (IT)
- Lund University (SE)
- Heidelberg University (DE)
- Goethe University Frankfurt (DE)
- University of Eastern Finland (FI)
- Corresponding author
- Clerx, Lies
- ORCID
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 34
- Issue
- 8
- Pages
- 2003-2013
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W1993773381
- Cited by
- 98
- References
- 7
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 8 · 2023: 2 · 2022: 9 · 2021: 12 · 2020: 5 · 2019: 5 · 2018: 6 · 2017: 12 · 2016: 7 · 2015: 19 · 2014: 8 · 2013: 1
- FWCI
- 8.30
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion, other-oa)
- Pure Amsterdam UMC (publishedVersion)
- Amsterdam UMC (VU Amsterdam) - Institutional Repository (publishedVersion)
- VU Research Portal (publishedVersion, other-oa)
- UCL Discovery (University College London) (submittedVersion)
- CINECA IRIS Institutial Research Information System (University of Genoa) (submittedVersion)
- Lund University Publications (Lund University) (submittedVersion)
- INFM-OAR (INFN Catania) (submittedVersion, other-oa)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Funders
- Seventh Framework Programme (211696)
- Center for Translational Molecular Medicine (02N-01)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- Alzheimer's disease, mild cognitive impairment, medial temporal lobe atrophy, hippocampal volume, lateral ventricle volume, cognitive decline, cerebrospinal fluid biomarkers, tau protein, phosphorylated tau, amyloid-beta 42
- MeSH terms
- Aged, Alzheimer Disease, Atrophy, Cognition, Female, Forecasting, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Peptide Fragments, Biomarkers, Amyloid beta-Peptides, tau Proteins, Disease Progression, Cognitive Dysfunction
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