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Cited by 224Advanced MRI Techniques and ApplicationsEpilepsy research and treatmentMedical Image Segmentation Techniques

The DOI matches its Crossref record; 31 of the 31 references it cites were found in a registry or an index.

MRI‐Based Hippocampal Volume Measurements in Epilepsy

Jack, Clifford R.·1994·Epilepsia
DOI 10.1111/j.1528-1157.1994.tb05986.x
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Abstract

Summary: In the study of brain morphometry, it is accepted that a relationship exists between brain structure and function, both normal and abnormal. One descriptor of morphometric structure is volume. Abnormalities in hippocampal morphology, including unilateral or bilateral volume loss, are known to occur in epilepsy, Alzheimer's disease, and in certain amnestic syndromes. Precise quantitation should improve understanding of the role of any biologic system in normal function and in disease. The objectives of magnetic resonance (MR)‐based hippocampal volume measurements are precise quantitation, identification of a normal range, and identification of the association between biologic variables and aberrations in this volumetric parameter. Volumetric measures introduce a level of precision in the estimation of hippocampal size that is not available simply by visually inspecting a set of MR images, thus enabling statistically based hypothesis testing. To produce accurate hippocampal volume measurements with magnetic resonance imaging (MRI), attention must be directed to the two major components of the operation as a whole, MR image acquisition and image processing.

Overview

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Crossref · 10.1111/j.1528-1157.1994.tb05986.x

Cites

31 of 31 references verified0 citation errors · 0 not checkable

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  • Of the three MTL structures measured, the anatomic boundaries presented by MRI are more precise, and less normal anatomic variability exists, for the hippocampus than for the amygdala or PHG.

    “Of the three MTL structures measured, the anatomic boundaries presented by MRI are more precise, and less normal anatomic variability exits, for the hippocampus than for the amygdala or PHG ([29](#R29)).”

    From Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease (1997) · cites this paper as [29]

  • The absolute numeric output of any image-based volume measurement technique is methodology-dependent.

    “One caveat however is that the absolute numeric output of any image based volume measurement technique is methodology-dependent([29](#R29)).”

    From Medial temporal atrophy on MRI in normal aging and very mild Alzheimer's disease (1997) · cites this paper as [29]

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Metadata

Authors
Jack, C. R.
Affiliations
Mayo Clinic (US)
Corresponding author
Jack, Clifford R.
ORCID
Jack, Clifford R.
Venue
Epilepsia
Publisher
Wiley
Published
1994-12
Volume
35
Issue
s6
Pages
S21-9
ISSN
  • 0013-9580 (ISSN-L)
  • 1528-1167
DOI
10.1111/j.1528-1157.1994.tb05986.x
OpenAlex
W2104517703
Cited by
224
References
31
Citations by year
2026: 1 · 2025: 2 · 2024: 1 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 3 · 2019: 3 · 2018: 4 · 2017: 6 · 2016: 3 · 2015: 3 · 2014: 8 · 2013: 5 · 2012: 6
FWCI
3.62
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor, 4722 d)
Locations
  • Epilepsia (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Neurological Disorders and Stroke (NS28374)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
  • Health Sciences › Medicine › Clinical Neurology › Epilepsy research and treatment
  • Physical Sciences › Computer Science › Computer Vision and Pattern Recognition › Medical Image Segmentation Techniques
Keywords
hippocampal volume, epilepsy, hippocampal atrophy, brain morphometry, volumetric MRI, reference values, image acquisition, image processing, hippocampal morphology
MeSH terms
Atrophy, Epilepsy, Epilepsy, Temporal Lobe, Hippocampus, Humans, Image Interpretation, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Reference Values, Temporal Lobe, Reproducibility of Results

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