Cited by 150Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsAdvanced Neuroimaging Techniques and Applications

Grey and white matter changes at different stages of Alzheimer’s disease

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Serra, Laura, Cercignani, Mara, Lenzi, Delia, Perri, Roberta, Fadda, Lucia, Caltagirone, Carlo, Macaluso, Emiliano, Bozzali, Marco·2010·Journal of Alzheimer's Disease

Abstract

This study investigates abnormalities of grey (GM) and white matter (WM) in Alzheimer's disease (AD), by modeling the AD pathological process as a continuous course between normal aging and fully developed dementia, with amnesic mild cognitive impairment (aMCI) as an intermediate stage. All subjects (9 AD, 16 aMCI patients, and 13 healthy controls) underwent a full neuropsychological assessment and an MRI examination at 3 Tesla, including a volumetric scan and diffusion tensor (DT)-MRI. The volumes were processed to perform a voxel-based morphometric analysis of GM and WM volume, while DT-MRI data were analyzed using tract based spatial statistics, to estimate changes in fractional anisotropy and mean diffusivity data. GM and WM volume and mean diffusivity and fractional anisotropy were compared across the three groups, and their correlation with cognitive functions was investigated. While AD presented a pattern of widespread GM atrophy, tissue loss was more subtle in patients with aMCI. WM atrophy was mainly located in the temporal lobe, but evidence of WM microscopic damage, assessed by DT-MRI, was also observable in the thalamic radiations and in the corpus callosum. Memory and executive functions correlated with either GM volume or fractional anisotropy in fronto-temporal areas. In conclusion, this study shows a comprehensive assessment of the brain tissue damage across AD evolution, providing insights on different pathophysiological mechanisms (GM atrophy, Wallerian dege…

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Registry

Crossref · 10.3233/jad-2010-1223

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  • Previous neuroimaging studies comparing GM changes between AD patients and healthy individuals have identified significant morphological atrophy in the hippocampus, entorhinal cortex, amygdala, putamen, and thalamus.

    “Previous neuroimaging studies comparing GM changes between AD patients and healthy individuals have identified significant morphological atrophy in the hippocampus, entorhinal cortex, amygdala, putamen, and thalamus (de Jong et al., 2008; Serra et al., 2010; Matsuda, 2013).”

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Authors
Serra, L., Cercignani, M., Lenzi, D., Perri, R., Fadda, L., Caltagirone, C., Macaluso, E., & Bozzali, M.
Affiliations
  • Fondazione Santa Lucia (IT)
  • University of Rome Tor Vergata (IT)
Corresponding author
Bozzali, Marco
Venue
Journal of Alzheimer's Disease
Published
2010-01-06
Volume
19
Issue
1
Pages
147-159
ISSN
  • 1387-2877 (ISSN-L)
  • 1875-8908
OpenAlex
W1568194840
Cited by
149
References
53
Citations by year
2026: 2 · 2025: 6 · 2024: 5 · 2023: 11 · 2022: 4 · 2021: 12 · 2020: 10 · 2019: 3 · 2018: 4 · 2017: 7 · 2016: 10 · 2015: 12 · 2014: 8 · 2013: 13 · 2012: 20
FWCI
11.56
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Journal of Alzheimer s Disease (publishedVersion)
  • PubMed (publishedVersion)
  • Cineca Institutional Research Information System (Tor Vergata University) (submittedVersion)
  • Figshare (submittedVersion, cc-by)
  • ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
  • Institutional Research Information System University of Turin (University of Turin) (submittedVersion)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
Keywords
Alzheimer's disease, gray matter atrophy
MeSH terms
Aged, Alzheimer Disease, Cerebral Cortex, Female, Humans, Male, Middle Aged, Nerve Fibers, Myelinated, Disease Progression

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