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BDNF Val66Met, Aβ amyloid, and cognitive decline in preclinical Alzheimer's disease
Abstract
Brain-derived neurotrophic factor (BDNF) Val66Met polymorphism has previously been implicated in Alzheimer's disease (AD)-related cognitive impairment. We aimed to determine the relationship between BDNF Val66Met and beta-amyloid (Aβ) on cognitive decline, hippocampal atrophy, and Aβ accumulation over 36 months in 165 healthy adults enrolled in the Australian Imaging, Biomarkers and Lifestyle study. In healthy adults with high Aβ, Met carriers showed significant and moderate-to-large declines in episodic memory, executive function, and language, and greater hippocampal atrophy over 36 months, compared with Val/Val homozygotes. BDNF Val66Met was not found to be related to rates of change in cognition or hippocampal volume in healthy adults with low Aβ. BDNF Val66Met did not relate to the amount of Aβ or to the rate of Aβ accumulation in either group. High Aβ levels coupled with Met carriage may be useful prognostic markers of accelerated cognitive decline and hippocampal degeneration in individuals in the preclinical stage of AD.
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“In the study conducted in healthy adults having a high Aβ level and carrying the Met allele, the rate of HV reduction was significantly more.”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [72]
In the citing paper
“A greater reduction rate in HV was observed in Val/Val homozygotes who were having high Aβ levels than with low Aβ, irrespective of their BDNF Val66Met polymorphism over 36 months.”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [72]
In the citing paper
“The decline in memory with the reduction in hippocampal volume (HV) corresponding with high Aβ levels has been already reported in healthy individuals; Lim et al. (2013) showed that BDNF Val66Met worsens these conditions more in the preclinical stage of AD [72].”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [72]
In the citing paper
“The decline in memory with the reduction in hippocampal volume (HV) corresponding with high Aβ levels has been already reported in healthy individuals; Lim et al. (2013) showed that BDNF Val66Met worsens these conditions more in the preclinical stage of AD [72].”
From Recent Advancements in Pathogenesis, Diagnostics and Treatment of Alzheimer’s Disease (2020) · cites this paper as [72]
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Metadata
- Authors
- Lim, Y. Y., Villemagne, V. L., Laws, S. M., Ames, D., Pietrzak, R. H., Ellis, K. A., Harrington, K. D., Bourgeat, P., Salvado, O., Darby, D., Snyder, P. J., Bush, A. I., Martins, R. N., Masters, C. L., Rowe, C. C., Nathan, P. J., & Maruff, P.
- Affiliations
- Mental Health Research Institute (AU)
- Edith Cowan University (AU)
- The University of Melbourne (AU)
- Yale University (US)
- Australian e-Health Research Centre (AU)
- Brown University (US)
- GlaxoSmithKline (United Kingdom) (GB)
- Corresponding author
- Lim, Yen Ying
- ORCID
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 34
- Issue
- 11
- Pages
- 2457-2464
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W1998751550
- Cited by
- 124
- References
- 40
- Citations by year
- 2026: 2 · 2025: 6 · 2024: 3 · 2023: 7 · 2022: 7 · 2021: 10 · 2020: 16 · 2019: 12 · 2018: 17 · 2017: 12 · 2016: 11 · 2015: 6 · 2014: 13 · 2013: 2
- FWCI
- 7.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Research Online (Edith Cowan University) (submittedVersion)
- Swinburne figshare (Swinburne University of Technology) (submittedVersion)
- Funders
- Australian Commonwealth Scientific Industrial and research Organization
- Edith Cowan University
- Mental Health Research institute (MHRI), Alzheimer's Australia
- National Ageing Research Institute
- Austin Health, CogState Ltd.
- Hollywood Private Hospital
- Sir Charles Gardner Hospital
- National Health and Medical Research Council
- Dementia Collaborative Research Centres
- Science and Industry Endowment Fund
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Oncology › Cancer-related cognitive impairment studies
- Keywords
- BDNF Val66Met polymorphism, brain-derived neurotrophic factor, amyloid-beta, preclinical Alzheimer's disease, cognitive decline, hippocampal atrophy, episodic memory, executive function, language, amyloid accumulation, prognostic factors
- MeSH terms
- Aged, Alzheimer Disease, Aniline Compounds, Australia, Cognition Disorders, Female, Genotype, Hippocampus, Humans, Magnetic Resonance Imaging, Male, Methionine, Neuropsychological Tests, Psychiatric Status Rating Scales, Thiazoles, Valine, Amyloid beta-Peptides, Brain-Derived Neurotrophic Factor, Positron-Emission Tomography, Apolipoprotein E4, Memory, Episodic
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