Fifteen Years of the Australian Imaging, Biomarkers and Lifestyle (AIBL) Study: Progress and Observations from 2,359 Older Adults Spanning the Spectrum from Cognitive Normality to Alzheimer’s Disease
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Background: The Australian Imaging, Biomarkers and Lifestyle (AIBL) Study commenced in 2006 as a prospective study of 1,112 individuals (768 cognitively normal (CN), 133 with mild cognitive impairment (MCI), and 211 with Alzheimer’s disease dementia (AD)) as an ‘Inception cohort’ who underwent detailed ssessments every 18 months. Over the past decade, an additional 1247 subjects have been added as an ‘Enrichment cohort’ (as of 10 April 2019). Objective: Here we provide an overview of these Inception and Enrichment cohorts of more than 8,500 person-years of investigation. Methods: Participants underwent reassessment every 18 months including comprehensive cognitive testing, neuroimaging (magnetic resonance imaging, MRI; positron emission tomography, PET), biofluid biomarkers and lifestyle evaluations. Results: AIBL has made major contributions to the understanding of the natural history of AD, with cognitive and biological definitions of its three major stages: preclinical, prodromal and clinical. Early deployment of Aβ-amyloid and tau molecular PET imaging and the development of more sensitive and specific blood tests have facilitated the assessment of genetic and environmental factors which affect age at onset and rates of progression. Conclusion: This fifteen-year study provides a large database of highly characterized individuals with longitudinal cognitive, imaging and lifestyle data and biofluid collections, to aid in the development of interventions to delay onset, prevent or treat AD. Harmonization with similar large longitudinal cohort studies is underway to further these aims.
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The AIBL study is a longitudinal study of over 1,117 volunteers and includes amyloid PET imaging and repeated cognitive and behavioral tests.
“The Australian Imaging, Biomarker and Lifestyle (AIBL) study of aging is a longitudinal study of over 1,117 volunteers and includes amyloid positron emission tomography (PET) imagining, as well as several repeated cognitive and behavioral tests [24].”
From Discovery of a Missense Mutation (Q222K) of the <i>APOE</i> Gene from the Australian Imaging, Biomarker and Lifestyle Study (2023) · cites this paper as [24]
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Self-citationA plasma protein classifier for predicting amyloid burden for preclinical Alzheimer’s disease
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Self-citationAPOE ε4 moderates amyloid-related memory decline in preclinical Alzheimer's disease
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Self-citationAβ and cognitive change: Examining the preclinical and prodromal stages of Alzheimer's disease
Lim, Y. Y., Maruff, P. T., Pietrzak, R. H., Ellis, K. A., Darby, D., Ames, D. J., Harrington, K., Martins, R. N., Masters, C. L., Szoeke, C. E. I., et al. (2014) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2013.11.005 · Cited by 80 · see citing works
Self-citationLim, Y., Kalinowski, P., Pietrzak, R., Laws, S., Burnham, S., Ames, D., Villemagne, V., Fowler, C., Rainey-Smith, S., Martins, R., et al. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2017.4325 · Cited by 80 · see citing works
Self-citationElecsys CSF biomarker immunoassays demonstrate concordance with amyloid-PET imaging
Doecke, J. D., Ward, L. D., Burnham, S. C., Villemagne, V. L., Li, Q.-X., Collins, S. J., Fowler, C. J., Manuilova, E., Widmann, M., Rainey‐Smith, S. R., et al. (2020) · Alzheimer s Research & Therapy · doi:10.1186/s13195-020-00595-5 · Cited by 79 · see citing works
Self-citationAssociation of Plasma Aß Peptides with Blood Pressure in the Elderly
Lambert, J., Dallongeville, J., Ellis, K. A., Schraen‐Maschke, S., Lui, J. K., Laws, S. M., Dumont, J., Richard, F., Cottel, D., Berr, C., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0018536 · Cited by 78 · see citing works
Self-citationLi, Q., Villemagne, V. L., Doecke, J. D., Rembach, A., Sarros, S., Varghese, S., McGlade, A. R., Laughton, K. M., Pertile, K. K., Fowler, C. J., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150247 · Cited by 73 · see citing works
Self-citationBlood-Borne Amyloid-β Dimer Correlates with Clinical Markers of Alzheimer's Disease
Villemagne, V. L., Perez, K. A., Pike, K. E., Kok, W. M., Rowe, C. C., White, A. R., Bourgeat, P., Salvado, O., Bedő, J., Hutton, C. A., et al. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5180-09.2010 · Cited by 71 · see citing works
Self-citationInnate phagocytosis by peripheral blood monocytes is altered in Alzheimer’s disease
The Australian Imaging, B. A. L. (. S., Gu, B. J., Huang, X., Ou, A., Rembach, A., Fowler, C. J., Avula, P. K., Horton, A., Doecke, J. D., Villemagne, V. L., et al. (2016) · Acta Neuropathologica · doi:10.1007/s00401-016-1596-3 · Cited by 68 · see citing works
Self-citationInfluence of BDNF Val66Met on the relationship between physical activity and brain volume
Brown, B. M., Bourgeat, P., Peiffer, J. J., Burnham, S. C., Laws, S. M., Rainey‐Smith, S. R., David Bartrés-faz, A., Villemagne, V. L., Taddei, K., Rembach, A., et al. (2014) · Neurology · doi:10.1212/wnl.0000000000000867 · Cited by 66 · see citing works
Self-citationThe Computerized Cognitive Composite (C3) in A4, an Alzheimer's Disease Secondary Prevention Trial
Papp, K. V., Rentz, D. M., Maruff, P. T., Sun, C., Raman, R., Donohue, M., Schembri, A. J., Stark, C. E. L., Yassa, M. A., Wessels, A. M., et al. (2021) · The Journal of Prevention of Alzheimer s Disease · doi:10.14283/jpad.2020.38 · Cited by 66 · see citing works
Self-citationRapid Decline in Episodic Memory in Healthy Older Adults with High Amyloid-β
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Self-citationMild memory impairment in healthy older adults is distinct from normal aging
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Self-citationAβ amyloid, cognition, and APOE genotype in healthy older adults
Lim, Y. Y., Ellis, K. A., Ames, D. J., Darby, D., Harrington, K., Martins, R. N., Masters, C. L., Rowe, C. C., Savage, G. R., Szoeke, C. E. I., et al. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.07.004 · Cited by 57 · see citing works
Self-citationAssociations of Dietary Protein and Fiber Intake with Brain and Blood Amyloid-β
Fernando, W. M. A. D. B., Rainey‐Smith, S. R., Gardener, S. L., Villemagne, V. L., Burnham, S. C., Macaulay, S. L., Brown, B. M., Gupta, V. B., Sohrabi, H. R., Weinborn, M., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-170742 · Cited by 56 · see citing works
Self-citationPorter, T., Burnham, S. C., Milicic, L., Savage, G. R., Maruff, P. T., Lim, Y. Y., Li, Q.-X., Ames, D. J., Masters, C. L., Rainey‐Smith, S. R., et al. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180713 · Cited by 56 · see citing works
Self-citationLim, Y., Pietrzak, R., Bourgeat, P., Ames, D., Ellis, K., Rembach, A., Harrington, K., Salvado, O., Martins, R., Snyder, P., et al. (2015) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acu068 · Cited by 53 · see citing works
Self-citationEllis, K. A., Szoeke, C. E. I., Bush, A. I., Darby, D., Graham, P. L., Lautenschlager, N. T., Macaulay, S. L., Martins, R. N., Maruff, P. T., Masters, C. L., et al. (2013) · International Psychogeriatrics · doi:10.1017/s1041610213001956 · Cited by 53 · see citing works
Self-citationLim, Y. Y., Baker, J. E., Bruns, L., Mills, A., Fowler, C. J., Fripp, J., Rainey‐Smith, S. R., Ames, D. J., Masters, C. L., & Maruff, P. T. (2020) · Neurology · doi:10.1212/wnl.0000000000010728 · Cited by 52 · see citing works
Self-citationFazlollahi, A., Calamante, F., Liang, X., Bourgeat, P., Raniga, P., Doré, V., Fripp, J., Ames, D. J., Masters, C. L., Rowe, C. C., et al. (2019) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.26810 · Cited by 51 · see citing works
Self-citationPlasma Amyloid-β Biomarker Associated with Cognitive Decline in Preclinical Alzheimer’s Disease
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Self-citationGupta, V. B., Doecke, J. D., Hone, E., Pedrini, S., Laws, S. M., Thambisetty, M., Bush, A. I., Rowe, C. C., Villemagne, V. L., Ames, D. J., et al. (2015) · Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring · doi:10.1016/j.dadm.2015.12.001 · Cited by 40 · see citing works
Self-citationLim, Y. Y., Williamson, R., Laws, S. M., Villemagne, V. L., Bourgeat, P., Fowler, C. J., Rainey‐Smith, S. R., Salvado, O., Martins, R. N., Rowe, C. C., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170072 · Cited by 40 · see citing works
Self-citationDang, C., Harrington, K., Lim, Y. Y., Ames, D. J., Hassenstab, J. J., Laws, S. M., Yassi, N., Hickey, M., Rainey‐Smith, S. R., Robertson, J. S., et al. (2018) · Archives of Clinical Neuropsychology · doi:10.1093/arclin/acy078 · Cited by 40 · see citing works
Self-citationDecline in verbal memory in non-demented older adults
Cargin, J. W., Maruff, P. T., Collie, A., Shafiq-Antonacci, R., & Masters, C. L. (2006) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13825580600954256 · Cited by 39 · see citing works
Self-citationAβ-related memory decline in APOE ε4 noncarriers
Lim, Y. Y., Laws, S. M., Villemagne, V. L., Pietrzak, R. H., Porter, T., Ames, D. J., Fowler, C. J., Rainey‐Smith, S. R., Snyder, P. J., Martins, R. N., et al. (2016) · Neurology · doi:10.1212/wnl.0000000000002604 · Cited by 37 · see citing works
Self-citationPorter, T., Burnham, S. C., Doré, V., Savage, G. R., Bourgeat, P., Begemann, K., Milicic, L., Ames, D. J., Bush, A. I., Maruff, P. T., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-20513-y · Cited by 37 · see citing works
Self-citationPorter, T., Burnham, S. C., Savage, G. R., Lim, Y. Y., Maruff, P. T., Milicic, L., Peretti, M., Ames, D. J., Masters, C. L., Martins, R. N., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00423 · Cited by 37 · see citing works
Self-citationRelationships Between Plasma Lipids Species, Gender, Risk Factors, and Alzheimer’s Disease
Lim, W. L. F., Huynh, K., Chatterjee, P., Martins, I. J., Jayawardana, K. S., Giles, C., Mellett, N. A., Laws, S. M., Bush, A. I., Rowe, C. C., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-191304 · Cited by 36 · see citing works
Self-citationThe association of Aβ amyloid and composite cognitive measures in healthy older adults and MCI
Harrington, K., Lim, Y. Y., Ellis, K. A., Copolov, C., Darby, D., Weinborn, M., Ames, D. J., Martins, R. N., Savage, G. R., Szoeke, C. E. I., et al. (2013) · International Psychogeriatrics · doi:10.1017/s1041610213001087 · Cited by 35 · see citing works
Self-citationLim, Y. Y., Ellis, K. A., Harrington, K., Pietrzak, R. H., Gale, J., Ames, D. J., Bush, A. I., Darby, D., Martins, R. N., Masters, C. L., et al. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-121771 · Cited by 34 · see citing works
Self-citationLim, Y. Y., Yassi, N., Bransby, L., Properzi, M. J., & Buckley, R. F. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-181139 · Cited by 33 · see citing works
Self-citationLongitudinal evaluation of the natural history of amyloid-β in plasma and brain
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Self-citationDoecke, J. D., Rembach, A., Villemagne, V. L., Varghese, S., Rainey‐Smith, S. R., Sarros, S., Evered, L. A., Fowler, C. J., Pertile, K. K., Rumble, R. L., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170128 · Cited by 31 · see citing works
Self-citationNabais, M. F., Lin, T., Benyamin, B., Williams, K. L., Garton, F. C., Vinkhuyzen, A. A. E., Zhang, F., Vallerga, C. L., Restuadi, R., Freydenzon, A., et al. (2020) · npj Genomic Medicine · doi:10.1038/s41525-020-0118-3 · Cited by 31 · see citing works
Predicting Alzheimer disease from a blood-based biomarker profile
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Self-citationPedrini, S., Gupta, V. B., Hone, E., Doecke, J. D., O’Bryant, S. E., JAMES, I. R., Bush, A. I., Rowe, C. C., Villemagne, V. L., Ames, D. J., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-14020-9 · Cited by 30 · see citing works
Self-citationInfluence of Comorbidity of Cerebrovascular Disease and Amyloid-β on Alzheimer’s Disease
Yassi, N., Hilal, S., Xia, Y., Lim, Y. Y., Watson, R., Kuijf, H. J., Fowler, C. J., Yates, P. A., Maruff, P. T., Martins, R. N., et al. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-191028 · Cited by 30 · see citing works
Self-citationPorter, T., Burnham, S. C., Milicic, L., Savage, G. R., Maruff, P. T., Lim, Y. Y., Ames, D. J., Masters, C. L., Martins, R. N., Rainey‐Smith, S. R., et al. (2019) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.12.014 · Cited by 28 · see citing works
Self-citationBransby, L., Lim, Y. Y., Ames, D. J., Fowler, C. J., Roberston, J., Harrington, K., Snyder, P. J., Villemagne, V. L., Salvado, O., Masters, C. L., et al. (2019) · Journal of Clinical and Experimental Neuropsychology · doi:10.1080/13803395.2019.1593949 · Cited by 28 · see citing works
Self-citationRembach, A., Evered, L. A., Li, Q., Nash, T., Vidaurre, L., Fowler, C. J., Pertile, K. K., Rumble, R. L., Trounson, B. O., Maher, S., et al. (2015) · Alzheimer s Research & Therapy · doi:10.1186/s13195-015-0157-7 · Cited by 27 · see citing works
Self-citationValidation of a priori candidate Alzheimer’s disease SNPs with brain amyloid-beta deposition
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Self-citationLim, Y. Y., Rainey‐Smith, S. R., Lim, Y. P., Laws, S. M., Gupta, V. B., Porter, T., Bourgeat, P., Ames, D. J., Fowler, C. J., Salvado, O., et al. (2017) · International Psychogeriatrics · doi:10.1017/s1041610217001284 · Cited by 25 · see citing works
Self-citationLim, Y., Villemagne, V., Laws, S., Pietrzak, R., Ames, D., Fowler, C., Rainey-Smith, S., Snyder, P., Bourgeat, P., Martins, R., et al. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-016-0822-8 · Cited by 22 · see citing works
Self-citationBaker, J. E., Pietrzak, R. H., Laws, S. M., Ames, D. J., Villemagne, V. L., Rowe, C. C., Masters, C. L., Maruff, P. T., & Lim, Y. Y. (2019) · Neuropsychology · doi:10.1037/neu0000561 · Cited by 22 · see citing works
Self-citationEstimates of age-related memory decline are inflated by unrecognized Alzheimer's disease
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Self-citationGardener, S. L., Rainey‐Smith, S. R., Sohrabi, H. R., Weinborn, M., Verdile, G., Fernando, W. M. A. D. B., Lim, Y. Y., Harrington, K., Burnham, S. C., Taddei, K., et al. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-161158 · Cited by 15 · see citing works
Self-citationRembach, A., Stingo, F. C., Peterson, C. B., Vannucci, M., Do, K.-A., Wilson, W. J., Macaulay, S. L., Ryan, T. M., Martins, R. N., Ames, D. J., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-141497 · Cited by 14 · see citing works
Self-citationComorbidity of Cerebrovascular and Alzheimer’s Disease in Aging
Xia, Y., Yassi, N., Raniga, P., Bourgeat, P., Desmond, P. M., Doecke, J. D., Ames, D. J., Laws, S. M., Fowler, C. J., Rainey‐Smith, S. R., et al. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200419 · Cited by 12 · see citing works
Self-citationPorter, T., Burnham, S. C., Milicic, L., Savage, G. R., Maruff, P. T., Sohrabi, H. R., Peretti, M., Lim, Y. Y., Weinborn, M., Ames, D. J., et al. (2019) · IBRO Reports · doi:10.1016/j.ibror.2019.05.001 · Cited by 5 · see citing works
Self-citationBradfield, N. I., Ellis, K. A., Savage, G. R., Maruff, P. T., Burnham, S. C., Darby, D., Lautenschlager, N. T., Martins, R. N., Masters, C. L., Rainey‐Smith, S. R., et al. (2020) · Journal of the International Neuropsychological Society · doi:10.1017/s135561772000079x · Cited by 4 · see citing works
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Self-citationAssociation of Basal Forebrain Atrophy With Cognitive Decline in Early Alzheimer Disease
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No Influence of Age-Related Hearing Loss on Brain Amyloid-β
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Self-citationIdentification of Leukocyte Surface P2X7 as a Biomarker Associated with Alzheimer’s Disease
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Self-citationLongitudinal trajectories of basal forebrain volume in normal aging and Alzheimer’s disease
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Causal functional connectivity in Alzheimer's disease computed from time series fMRI data
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Cross‐Dataset Evaluation of Dementia Longitudinal Progression Prediction Models
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Mind the Gap: Does Brain Age Improve Alzheimer’s Disease Prediction?
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Self-citationLeukocyte surface biomarkers implicate deficits of innate immunity in sporadic Alzheimer's disease
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Self-citationAdvancements and challenges in using AI for biomarker detection in early Alzheimer’s disease
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Overview of Challenges in Brain-Based Predictive Modeling: Toward Meaningful Predictive Insights
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Epigenetic age acceleration in peripheral blood correlates with brain-MRI age acceleration
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A Paradox in Digital Memory Assessment: Increased Sensitivity With Reduced Difficulty
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Self-citationAssociation of plastic-associated chemicals with Alzheimer's disease amyloid-β and cognitive status
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Self-citationUnraveling Normal Anatomy via Fluid-Driven Anomaly Randomization
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Self-citationMitochondrial methylcytosines as blood-based biomarkers for Alzheimer’s disease dementia prognosis
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Self-citation“Brain health”—the emergence of a new healthy construct and its role in everyday life
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Plasma Aβ42/40 predicts progression from Aβ-amyloid negative to positive PET scans
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Self-citation
- Authors
- Fowler, C., Rainey-Smith, S. R., Bird, S., Bomke, J., Bourgeat, P., Brown, B. M., Burnham, S. C., Bush, A. I., Chadunow, C., Collins, S., Doecke, J., Doré, V., Ellis, K. A., Evered, L., Fazlollahi, A., Fripp, J., Gardener, S. L., Gibson, S., Grenfell, R., Harrison, E., Head, R., Jin, L., Kamer, A., Lamb, F., Lautenschlager, N. T., Laws, S. M., Li, Q.-X., Lim, L., Lim, Y. Y., Louey, A., Macaulay, S. L., Mackintosh, L., Martins, R. N., Maruff, P., Masters, C. L., McBride, S., Milicic, L., Peretti, M., Pertile, K., Porter, T., Radler, M., Rembach, A., Robertson, J., Rodrigues, M., Rowe, C. C., Rumble, R., Salvado, O., Savage, G., Silbert, B., Soh, M., Sohrabi, H. R., Taddei, K., Taddei, T., Thai, C., Trounson, B., Tyrrell, R., Vacher, M., Varghese, S., Villemagne, V. L., Weinborn, M., Woodward, M., Xia, Y., Ames, D., & the AIBL investigators
- Affiliations
- The University of Melbourne (AU)
- Centre of Excellence for Alzheimer’s Disease Research and Care, School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia
- Edith Cowan University (AU)
- Commonwealth Scientific and Industrial Research Organisation (AU)
- Murdoch University (AU)
- Department of Anaesthesia and Acute Pain Medicine, St Vincent’s Hospital Melbourne, Victoria Parade, Fitzroy, VIC, Australia
- Australian E-Health Research Centre, CSIRO Health & Biosecurity, Herston, QLD, Australia
- Austin Hospital (AU)
- Cogstate Limited, Melbourne, VIC, Australia
- Macquarie University (AU)
- St Vincent's Hospital Melbourne (AU)
- University of Pittsburgh (US)
- Corresponding author
- Masters, Colin L.
- ORCID
- Fowler, Christopher
- Bomke, Julia
- Bourgeat, Pierrick
- Brown, Belinda M.
- Burnham, Samantha C.
- Bush, Ashley I.
- Collins, Steven
- Doecke, James
- Doré, Vincent
- Ellis, Kathryn A.
- Fazlollahi, Amir
- Gardener, Samantha L.
- Head, Richard
- Jin, Liang
- Lautenschlager, Nicola T.
- Laws, Simon M.
- Li, Qiao-Xin
- Lim, Yen Ying
- Macaulay, S. Lance
- Mackintosh, Lucy
- Martins, Ralph N.
- Maruff, Paul
- Masters, Colin L.
- McBride, Simon
- Milicic, Lidija
- Peretti, Madeline
- Porter, Tenielle
- Rodrigues, Mark
- Rowe, Christopher C.
- Salvado, Olivier
- Savage, Greg
- Silbert, Brendan
- Sohrabi, Hamid R.
- Taddei, Kevin
- Vacher, Michael
- Villemagne, Victor L.
- Weinborn, Michael
- Xia, Ying
- Venue
- Journal of Alzheimer's Disease Reports
- Publisher
- SAGE Publications
- Published
- 2021-03-11
- Volume
- 5
- Issue
- 1
- Pages
- 443-468
- ISSN
- 2542-4823 (ISSN-L)
- PMC
- PMC8293663
- OpenAlex
- W3167322081
- Cited by
- 164
- References
- 127
- Citations by year
- 2026: 27 · 2025: 42 · 2024: 41 · 2023: 21 · 2022: 30 · 2021: 3
- FWCI
- 17.03
- Type
- journal article
- Language
- en
- Open access
- diamond
- doi.org
- Licence
- Locations
- Journal of Alzheimer s Disease Reports (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- QUT ePrints (Queensland University of Technology) (submittedVersion, cc-by-nc)
- Minerva Access (University of Melbourne) (submittedVersion, cc-by-nc)
- Murdoch University Research Portal (submittedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion, cc-by-nc)
- Australasian Journal of Paramedicine (submittedVersion, cc-by-nc)
- Edith Cowan University Research Online (Edith Cowan University) (submittedVersion, cc-by-nc)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Eli Lilly and Company
- Pfizer
- AstraZeneca
- Elan
- Avid Radiopharmaceuticals
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
- Keywords
- Alzheimer's disease, mild cognitive impairment, preclinical Alzheimer's disease, prodromal Alzheimer's disease, amyloid PET, tau PET, blood biomarkers, neuroimaging, cognitive decline, older adults, longitudinal cohort, disease progression, age of onset
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