Molecular mechanisms of brain-derived neurotrophic factor in neuro-protection: Recent developments
Abstract
Neuronal cell injury, as a consequence of acute or chronic neurological trauma, is a significant cause of mortality around the world. On a molecular level, the condition is characterized by widespread cell death and poor regeneration, which can result in severe morbidity in survivors. Potential therapeutics are of major interest, with a promising candidate being brain-derived neurotrophic factor (BDNF), a ubiquitous agent in the brain which has been associated with neural development and may facilitate protective and regenerative effects following injury. This review summarizes the available information on the potential benefits of BDNF and the molecular mechanisms involved in several pathological conditions, including hypoxic brain injury, stroke, Alzheimer's disease and Parkinson's disease. It further explores the methods in which BDNF can be applied in clinical and therapeutic settings, and the potential challenges to overcome.
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Currently, it is not possible to ensure that BDNF acts on precise target regions without affecting the function of neighboring areas.
“Furthermore, currently, it is not possible to ensure that BDNF acts on precise target regions without affecting the function of neighboring areas [112].”
From BDNF as a Promising Therapeutic Agent in Parkinson’s Disease (2020) · cites this paper as [112]
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Upregulation Effect of Citrus Species on Brain-Derived Neurotrophic Factor
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- Authors
- Zhao, H., Alam, A., San, C.-Y., Eguchi, S., Chen, Q., Lian, Q., & Ma, D.
- Affiliations
- Chelsea and Westminster Hospital (GB)
- Army Medical University (CN)
- Wenzhou Medical University (CN)
- Corresponding author
- Lian, Qingquan
- Ma, Daqing
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2017-06
- Volume
- 1665
- Pages
- 1-21
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2604803509
- Cited by
- 122
- References
- 340
- Citations by year
- 2026: 5 · 2025: 12 · 2024: 9 · 2023: 7 · 2022: 16 · 2021: 11 · 2020: 14 · 2019: 22 · 2018: 17 · 2017: 9
- FWCI
- 2.09
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Sparks
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Keywords
- brain-derived neurotrophic factor, neuroprotection, neuronal cell death, neurological trauma, hypoxic brain injury, stroke, Alzheimer's disease, Parkinson's disease, nerve regeneration, therapeutic target
- MeSH terms
- Alzheimer Disease, Animals, Brain, Hypoxia, Brain, Humans, Neurons, Parkinson Disease, Brain-Derived Neurotrophic Factor
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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