Cited by 122Nerve injury and regenerationNeurological Disorders and TreatmentsNuclear Receptors and Signaling

Molecular mechanisms of brain-derived neurotrophic factor in neuro-protection: Recent developments

Zhao, Hailin, Alam, Azeem, San, Chun-Yin, Eguchi, Shiori, Chen, Qian, Lian, Qingquan, Ma, Daqing·2017·Brain Research

Abstract

Neuronal cell injury, as a consequence of acute or chronic neurological trauma, is a significant cause of mortality around the world. On a molecular level, the condition is characterized by widespread cell death and poor regeneration, which can result in severe morbidity in survivors. Potential therapeutics are of major interest, with a promising candidate being brain-derived neurotrophic factor (BDNF), a ubiquitous agent in the brain which has been associated with neural development and may facilitate protective and regenerative effects following injury. This review summarizes the available information on the potential benefits of BDNF and the molecular mechanisms involved in several pathological conditions, including hypoxic brain injury, stroke, Alzheimer's disease and Parkinson's disease. It further explores the methods in which BDNF can be applied in clinical and therapeutic settings, and the potential challenges to overcome.

Integrity signals

Registry

Crossref · 10.1016/j.brainres.2017.03.029

Cites

338 of 338 references verified0 citation errors · 0 not checkable

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  • Currently, it is not possible to ensure that BDNF acts on precise target regions without affecting the function of neighboring areas.

    “Furthermore, currently, it is not possible to ensure that BDNF acts on precise target regions without affecting the function of neighboring areas [112].”

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Authors
Zhao, H., Alam, A., San, C.-Y., Eguchi, S., Chen, Q., Lian, Q., & Ma, D.
Affiliations
  • Chelsea and Westminster Hospital (GB)
  • Army Medical University (CN)
  • Wenzhou Medical University (CN)
Corresponding author
  • Lian, Qingquan
  • Ma, Daqing
Venue
Brain Research
Publisher
Elsevier BV
Published
2017-06
Volume
1665
Pages
1-21
ISSN
0006-8993 (ISSN-L)
OpenAlex
W2604803509
Cited by
122
References
340
Citations by year
2026: 5 · 2025: 12 · 2024: 9 · 2023: 7 · 2022: 16 · 2021: 11 · 2020: 14 · 2019: 22 · 2018: 17 · 2017: 9
FWCI
2.09
Type
journal article
Language
en
Open access
closed
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
Sparks
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
  • Life Sciences › Neuroscience › Neurology › Neurological Disorders and Treatments
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
Keywords
brain-derived neurotrophic factor, neuroprotection, neuronal cell death, neurological trauma, hypoxic brain injury, stroke, Alzheimer's disease, Parkinson's disease, nerve regeneration, therapeutic target
MeSH terms
Alzheimer Disease, Animals, Brain, Hypoxia, Brain, Humans, Neurons, Parkinson Disease, Brain-Derived Neurotrophic Factor

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