Lutein Supplementation for Eye Diseases
Open accessAbstract
Lutein is one of the few xanthophyll carotenoids that is found in high concentration in the macula of human retina. As de novo synthesis of lutein within the human body is impossible, lutein can only be obtained from diet. It is a natural substance abundant in egg yolk and dark green leafy vegetables. Many basic and clinical studies have reported lutein’s anti-oxidative and anti-inflammatory properties in the eye, suggesting its beneficial effects on protection and alleviation of ocular diseases such as age-related macular degeneration, diabetic retinopathy, retinopathy of prematurity, myopia, and cataract. Most importantly, lutein is categorized as Generally Regarded as Safe (GRAS), posing minimal side-effects upon long term consumption. In this review, we will discuss the chemical structure and properties of lutein as well as its application and safety as a nutritional supplement. Finally, the effects of lutein consumption on the aforementioned eye diseases will be reviewed.
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OS-induced senescence is involved in the pathogenesis of age-related macular degeneration (AMD), which represents the leading cause of blindness in aged individuals.
“There is evidence that OS-induced senescence is involved in the pathogenesis of age-related macular degeneration (AMD), which represents the leading cause of blindness in aged individuals [158,164,165].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [158]
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Research works printed but not linked: 1
- [139]EJ T. The Optical Elements of the Refractive Power of the Eye Hoeber Press New York, NY, USA 1940
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The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works
- Authors
- Li, L. H., Lee, J. C.-Y., Leung, H. H., Lam, W. C., Fu, Z., & Lo, A. C. Y.
- Affiliations
- University of Hong Kong (HK)
- Boston Children's Hospital (US)
- Department of Ophthalmology, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China
- Corresponding author
- Fu, Zhongjie
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2020-06-09
- Volume
- 12
- Issue
- 6
- Pages
- 1721
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC7352796
- OpenAlex
- W3034751100
- Cited by
- 152
- References
- 169
- Citations by year
- 2026: 22 · 2025: 26 · 2024: 32 · 2023: 32 · 2022: 24 · 2021: 14 · 2020: 2
- FWCI
- 3.05
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Health and Medical Research Fund, the Food and Health Bureau, The Government of the Hong Kong Special Administrative Region (04150746)
- Boston Children's Hospital OFD/BTREC/CTREC Faculty Career Development Grant (N/A)
- Boston Children's Hospital Ophthalmology Foundation (N/A)
- Boston Children's Hospital Manton Center for Orphan Disease Research (N/A)
- Little Giraffe Foundation (N/A)
- Topics
- Health Sciences › Medicine › Ophthalmology › Retinal Diseases and Treatments
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Keywords
- lutein, lutein supplementation, eye diseases, age-related macular degeneration, diabetic retinopathy, retinopathy of prematurity, myopia, cataract, antioxidant activity, anti-inflammatory activity, GRAS
- MeSH terms
- Animals, Biological Availability, Cataract, Diabetic Retinopathy, Diet, Eye Diseases, Humans, Macula Lutea, Macular Degeneration, Myopia, Plants, Edible, Retinopathy of Prematurity, Lutein, Dietary Supplements
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