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Identification of Alzheimer's disease–associated long noncoding RNAs
Abstract
Alzheimer's disease (AD) is the most common dementia among the elderly that involves complex neurodegenerative alterations. Multiple cellular processes including regulation of amyloid-β peptide, tau, inflammation, and cell death have been suggested to associate with AD, but it remains largely unknown if long noncoding RNAs (lncRNAs) may be playing a role in AD pathogenesis. Here, we identify AD-associated lncRNAs by reannotation of microarray data based on postmortem tissue samples of AD patients and matched elderly controls. We found 24 upregulated and 84 downregulated lncRNAs in AD patients compared with controls, most being intergenic. An analysis of lncRNAs in various tissues indicated that most downregulated lncRNAs in AD are highly expressed in the brain but not in other tissues. Gene set enrichment analysis identified a downregulated lncRNA n341006 in association with protein ubiquitination pathway, and a significantly upregulated lncRNA n336934 linked to cholesterol homeostasis. Interestingly, lncRNA expression signatures could predict tissue types with equal accuracy as protein-coding genes, but the number of lncRNAs required for optimal prediction was less than protein-coding genes. Taken together, our study provides a resource for AD-associated lncRNAs for the development of lncRNA biomarkers and the identification of functional lncRNAs involved in AD pathogenesis.
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“Among them, LINC02552 has been reported to be associated with genes involved in protein homeostasis pathways (41).”
From Comprehensive characterization of the transcriptional landscape in Alzheimer’s disease (AD) brains (2025) · cites this paper as [41]
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Metadata
- Authors
- Zhou, X., & Xu, J.
- Affiliations
- Shanghai Jiao Tong University (CN)
- Corresponding author
- Zhou, Xiaolin
- Xu, Jie
- ORCID
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2015-11
- Volume
- 36
- Issue
- 11
- Pages
- 2925-2931
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W1854922036
- Cited by
- 102
- References
- 56
- Citations by year
- 2025: 4 · 2024: 5 · 2023: 4 · 2022: 9 · 2021: 14 · 2020: 17 · 2019: 11 · 2018: 22 · 2017: 6 · 2016: 10
- FWCI
- 4.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (81200976, 81272383, 81322036)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer-related molecular mechanisms research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Keywords
- Alzheimer's disease, long non-coding RNA, lncRNA expression profiling, postmortem brain, lncRNA biomarkers, ubiquitination, cholesterol homeostasis, intergenic lncRNAs, amyloid-beta, tau protein, neurodegeneration
- MeSH terms
- Alzheimer Disease, Brain, Cholesterol, Homeostasis, Humans, Proteins, Down-Regulation, Up-Regulation, Gene Expression, RNA, Untranslated, Microarray Analysis, Ubiquitination, Genetic Association Studies
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