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Acyl-coenzyme A:cholesterol acyltransferase 1 blockage enhances autophagy in the neurons of triple transgenic Alzheimer’s disease mouse and reduces human P301L-tau content at the presymptomatic stage

Shibuya, Yohei, Niu, Zhaoyang, Bryleva, Elena Y., Harris, Brent T., Murphy, Stephanie R., Kheirollah, Alireza, Bowen, Zachary D., Chang, Catherine C.Y., Chang, Ta-Yuan·2015·Neurobiology of Aging
DOI 10.1016/j.neurobiolaging.2015.04.002PMC PMC4457653
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  • Inhibition of cholesterol esterification by genetic deletion of ACAT1 prevents early stage Tau pathology in Tau mutant mice through unknown mechanisms.

    “inhibition of cholesterol esterification by genetic deletion of ACAT1 prevents early stage Tau pathology in Tau mutant mice through unknown mechanisms (Shibuya et al., 2015).”

    From Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons (2019) · cites this paper as Shibuya et al., 2015

    Results §3.7 (page unavailable) reports that Acat1 knockout reduced P301L-tau protein in young 3XTg-AD mice, supporting an early-stage effect. It does not establish that tau pathology was prevented: phosphorylation was not detectable in either group at two months, and older mice showed no reduction in phosphorylated tau or neurofibrillary tangles. Results §3.5 also links the reduction to increased autophagosome formation, so describing the mechanism as wholly unknown overlooks the mechanism the paper proposes. (LLM, conf=0.86)

    Experimental — accuracy not yet measured

  • In an AD-mouse model, genetic inhibition of CE by ACAT1 reduces tauopathy.

    “In an AD-mouse model, genetic inhibition of CE by acetyl-CoA acetyltransferase 1 (ACAT1) reduces tauopathy34.”

    From GRAMD1B is a regulator of lipid homeostasis, autophagic flux and phosphorylated tau (2025) · cites this paper as [34]

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Metadata

Authors
Shibuya, Y., Niu, Z., Bryleva, E. Y., Harris, B. T., Murphy, S. R., Kheirollah, A., Bowen, Z. D., Chang, C. C. Y., & Chang, T.-Y.
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2015-07
Volume
36
Issue
7
Pages
2248-2259
ISSN
0197-4580
DOI
10.1016/j.neurobiolaging.2015.04.002
PMC
PMC4457653
Cited by
87
References
15
Language
en
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Funders
National Institutes of Health (AG37609)

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