The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
The inflammatory markers CRP, IL-6, and IL-10 are associated with cognitive function—data from the Berlin Aging Study II
Abstract
Inflammation may be an underlying mechanism in cognitive decline. The present study investigated the relationship between cognitive function and the inflammatory markers C-reactive protein (CRP), interleukin (IL)-6, and IL-10 in a nonclinical sample of elderly adults. Serum levels of CRP, IL-6, and IL-10 were measured in n = 1312 elderly adults (60-85 years, 50.5% females) who underwent comprehensive neuropsychological testing. Multiple linear regression analysis was conducted and adjusted for various demographic and clinical factors. Levels of IL-6, IL-10, and CRP were negatively associated with a composite score of executive function and processing speed, whereas the IL-6 to IL-10 ratio was not predictive for executive function and processing speed. No associations were found between inflammatory markers and verbal episodic memory. These findings suggest a relationship between higher proinflammatory and anti-inflammatory activation of the innate immune system and executive function within the normal range. Further research is needed to examine the relevance of an inflammatory pathway as a potential therapeutic target.
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“In humans, the distinguishing criteria for normal vs pathological aging are: central nervous system (CNS) injury, amyloid plaques (based on positron emission tomography (PET)), neurodegeneration, neuropsychiatric conditions, dementia, and impaired performance on cognitive tests (Arani et al, 2015;Fabbri et al, 2016;Tegeler et al, 2016).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Tegeler et al, 2016
In the citing paper
“For instance, a recent cross-sectional study investigating the association between inflammatory markers and executive functioning in an elderly population indicated an age-associated increase in the serum expression of C-reactive protein (CRP), IL-6 and IL-10.Elevated levels of these cytokines were inversely associated with executive performance on neuropsychological tests (Tegeler et al, 2016).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Tegeler et al, 2016
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Microglia Priming with Aging and Stress
Niraula, A., Sheridan, J. F., & Godbout, J. P. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.185 · Cited by 398
Liu, X., Ma, Y., Ouyang, R., Zeng, Z., Zhan, Z., Lu, H., Cui, Y., Dai, Z., Luo, L., He, C., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01905-2 · Cited by 249
Sungkarat, S., Boripuntakul, S., Kumfu, S., Lord, S., & Chattipakorn, N. (2018) · Neurorehabilitation and Neural Repair · doi:10.1177/1545968317753682 · Cited by 167
Tang, Y., Fung, E., Xu, A., & Lan, H. Y. (2017) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12758 · Cited by 146
Systemic Inflammation Mediates Age-Related Cognitive Deficits
Lin, T., Liu, G. A., Perez, E., Rainer, R. D., Febo, M., Cruz-Almeida, Y., & Ebner, N. C. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00236 · Cited by 138
Metadata
- Authors
- Tegeler, C., O'Sullivan, J. L., Bucholtz, N., Goldeck, D., Pawelec, G., Steinhagen-Thiessen, E., & Demuth, I.
- Affiliations
- Charité – Universitätsmedizin Berlin (DE)
- University of Tübingen (DE)
- Corresponding author
- Tegeler, Christina
- Demuth, Ilja
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 38
- Pages
- 112-117
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2167109574
- Cited by
- 163
- References
- 42
- Citations by year
- 2026: 14 · 2025: 19 · 2024: 23 · 2023: 20 · 2022: 14 · 2021: 19 · 2020: 18 · 2019: 13 · 2018: 10 · 2017: 7 · 2016: 6
- FWCI
- 6.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bundesministerium für Bildung und Forschung (16SV5536K)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- C-reactive protein, interleukin-6, IL-10, inflammation, cognitive function, executive function, processing speed, verbal episodic memory, cognitive decline, older adults, innate immune system
- MeSH terms
- Aged, Aged, 80 and over, C-Reactive Protein, Cognition, Female, Humans, Immunity, Innate, Male, Middle Aged, Interleukin-6, Linear Models, Interleukin-10, Inflammation Mediators, Executive Function
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