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The inflammatory markers CRP, IL-6, and IL-10 are associated with cognitive function—data from the Berlin Aging Study II
Abstract
Inflammation may be an underlying mechanism in cognitive decline. The present study investigated the relationship between cognitive function and the inflammatory markers C-reactive protein (CRP), interleukin (IL)-6, and IL-10 in a nonclinical sample of elderly adults. Serum levels of CRP, IL-6, and IL-10 were measured in n = 1312 elderly adults (60-85 years, 50.5% females) who underwent comprehensive neuropsychological testing. Multiple linear regression analysis was conducted and adjusted for various demographic and clinical factors. Levels of IL-6, IL-10, and CRP were negatively associated with a composite score of executive function and processing speed, whereas the IL-6 to IL-10 ratio was not predictive for executive function and processing speed. No associations were found between inflammatory markers and verbal episodic memory. These findings suggest a relationship between higher proinflammatory and anti-inflammatory activation of the innate immune system and executive function within the normal range. Further research is needed to examine the relevance of an inflammatory pathway as a potential therapeutic target.
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“In humans, the distinguishing criteria for normal vs pathological aging are: central nervous system (CNS) injury, amyloid plaques (based on positron emission tomography (PET)), neurodegeneration, neuropsychiatric conditions, dementia, and impaired performance on cognitive tests (Arani et al, 2015;Fabbri et al, 2016;Tegeler et al, 2016).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Tegeler et al, 2016
In the citing paper
“For instance, a recent cross-sectional study investigating the association between inflammatory markers and executive functioning in an elderly population indicated an age-associated increase in the serum expression of C-reactive protein (CRP), IL-6 and IL-10.Elevated levels of these cytokines were inversely associated with executive performance on neuropsychological tests (Tegeler et al, 2016).”
From Microglia Priming with Aging and Stress (2017) · cites this paper as Tegeler et al, 2016
Citations
Cites
The CES-D Scale: A Self-Report Depression Scale for Research in the General Population
Radloff, L. S. (1977) · Applied Psychological Measurement · doi:10.1177/014662167700100306 · Cited by 53,267
Discovering Statistics Using SPSS
Field, A. P., & Miles, J. N. V. (2000) · Medical Entomology and Zoology · Cited by 28,269
A compendium of neuropsychological tests: administration, norms, and commentary
(1991) · Choice Reviews Online · doi:10.5860/choice.29-2400 · Cited by 6,118
A Compendium of Neuropsychological Tests: Administration, Norms, and Commentary
Levin, H. S. (1993) · Archives of Neurology · doi:10.1001/archneur.1993.00540050007005 · Cited by 4,796
The Neuropsychological Assessment
Ogden, J. A. (2005) · Oxford University Press eBooks · doi:10.1093/oso/9780195171358.003.0002 · Cited by 4,382
Chronic Subclinical Inflammation as Part of the Insulin Resistance Syndrome
Festa, A., D’Agostino, R., Howard, G., Mykkänen, L., Tracy, R. P., & Haffner, S. M. (2000) · Circulation · doi:10.1161/01.cir.102.1.42 · Cited by 2,366
Assessment of executive functions: Review of instruments and identification of critical issues.
CHAN, R., SHUM, D., TOULOPOULOU, T., & CHEN, E. (2008) · Archives of Clinical Neuropsychology · doi:10.1016/j.acn.2007.08.010 · Cited by 1,401
Age-associated cognitive decline
Deary, I. J., Corley, J., Gow, A. J., Harris, S. E., Houlihan, L. M., Marioni, R. E., Penke, L., Rafnsson, S. B., & Starr, J. M. (2009) · British Medical Bulletin · doi:10.1093/bmb/ldp033 · Cited by 1,295
The metabolic syndrome, inflammation, and risk of cognitive decline
Yaffe, K. (2004) · JAMA · doi:10.1001/jama.292.18.2237 · Cited by 1,025
Cardiovascular risk factors and cognitive decline in middle-aged adults
Knopman, D., Boland, L. L., Mosley, T., Howard, G., Liao, D., Szklo, M., McGovern, P., & Folsom, A. R. (2001) · Neurology · doi:10.1212/wnl.56.1.42 · Cited by 883
Obesity and neuroinflammation: A pathway to cognitive impairment
Miller, A. A., & Spencer, S. J. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.04.001 · Cited by 834
Cytokines and cognition–the case for a head-to-toe inflammatory paradigm.
Wilson, C. J., Finch, C. E., & Cohen, H. J. (2002) · Journal of the American Geriatrics Society · doi:10.1046/j.1532-5415.2002.50619.x · Cited by 637
Relations Between Cognitive Abilities and Measures of Executive Functioning.
Salthouse, T. A. (2005) · Neuropsychology · doi:10.1037/0894-4105.19.4.532 · Cited by 539
Interleukin-6 and risk of cognitive decline: MacArthur Studies of Successful Aging
Weaver, J. D., Huang, M.-H., Albert, M., Harris, T., Rowe, J. W., & Seeman, T. E. (2002) · Neurology · doi:10.1212/wnl.59.3.371 · Cited by 536
Inflammation, ageing and chronic disease
Pawelec, G., Goldeck, D., & Derhovanessian, E. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.03.007 · Cited by 434
Self-citationKuo, H., Yen, C., Chang, C., Kuo, C.-K., Chen, J.-H., & Sorond, F. A. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70099-5 · Cited by 409
CDC/AHA Workshop on Markers of Inflammation and Cardiovascular Disease
Myers, G. L., Rifai, N., Tracy, R. P., Roberts, W. L., Alexander, R. W., Biasucci, L. M., Catravas, J. D., Cole, T. G., Cooper, G. R., Khan, B. V., et al. (2004) · Circulation · doi:10.1161/01.cir.0000148980.87579.5e · Cited by 406
Interleukin-6 Covaries Inversely with Hippocampal Grey Matter Volume in Middle-Aged Adults
Marsland, A. L., Gianaros, P. J., Abramowitch, S. M., Manuck, S. B., & Hariri, A. R. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.04.016 · Cited by 348
Discovering Statistics Using spss . Second Edition
Gigliotti, E. (2007) · Journal of Advanced Nursing · doi:10.1111/j.1365-2648.2007.04270_1.x · Cited by 343
Systemic markers of inflammation and cognitive decline in old age
Schram, M. T., Euser, S. M., De Craen, A. J. M., Witteman, J. C., Frölich, M., Hofman, A., Jolles, J., Breteler, M. M. B., & Westendorp, R. G. J. (2007) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2007.01159.x · Cited by 326
Brain morphology links systemic inflammation to cognitive function in midlife adults
Marsland, A. L., Gianaros, P. J., Kuan, D. C.-H., Sheu, L. K., Krajina, K., & Manuck, S. B. (2015) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2015.03.015 · Cited by 321
Cevenini, E., Monti, D., & Franceschi, C. (2013) · Current Opinion in Clinical Nutrition and Metabolic Care · doi:10.1097/mco.0b013e32835ada13 · Cited by 317
Circulating IL-6 and CRP are associated with MRI findings in the elderly
Satizábal, C. L., Zhu, Y., Mazoyer, B. M., Dufouil, C., & Tzourio, C. (2012) · Neurology · doi:10.1212/wnl.0b013e318248e50f · Cited by 312
Inflamm-aging does not simply reflect increases in pro-inflammatory markers
Morrisette-Thomas, V., Cohen, A. A., Fülöp, T., Riesco, É., Legault, V., Li, Q., Milot, E., Dusseault-Bélanger, F., & Ferrucci, L. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2014.06.005 · Cited by 283
Stolp, H. B., & Dzięgielewska, K. M. (2008) · Neuropathology and Applied Neurobiology · doi:10.1111/j.1365-2990.2008.01005.x · Cited by 263
Contribution of Metabolic Syndrome Components to Cognition in Older Individuals
Dik, M. G., Jonker, C., Comijs, H. C., Deeg, D. J. H., Kok, A., Yaffe, K. S., & Penninx, B. W. J. H. (2007) · Diabetes Care · doi:10.2337/dc06-1190 · Cited by 258
5.4 Hamburg-Wechsler Intelligenztest für Erwachsene, Revision 1991 (Tewes, 1994)
(2001) · Thieme eBooks · doi:10.1055/b-0034-5328 · Cited by 251
Cohort Profile: The Berlin Aging Study II (BASE-II)†
Bertram, L., Böckenhoff, A., Demuth, I., Düzel, S., Eckardt, R., Li, S., Lindenberger, U., Pawelec, G., Siedler, T., Wagner, G. G., et al. (2013) · International Journal of Epidemiology · doi:10.1093/ije/dyt018 · Cited by 250
Self-citationSerum C-reactive protein is linked to cerebral microstructural integrity and cognitive function
Wersching, H., Duning, T., Lohmann, H., Mohammadi, S., Stehling, C., Fobker, M., Conty, M., Minnerup, J., Ringelstein, E. B., Berger, K., et al. (2010) · Neurology · doi:10.1212/wnl.0b013e3181d7b45b · Cited by 234
Neuropsychological Assessment, Fourth Edition
Kapur, N. (2005) · Journal of Neurology · doi:10.1007/s00415-005-0003-0 · Cited by 189
Cognitive dysfunction with aging and the role of inflammation
Simen, A. A., Bordner, K. A., Martin, M. P., Moy, L. A., & Barry, L. C. (2011) · Therapeutic Advances in Chronic Disease · doi:10.1177/2040622311399145 · Cited by 186
Interleukin-6 Covaries Inversely With Cognitive Performance Among Middle-Aged Community Volunteers
Marsland, A. L., Petersen, K. L., Sathanoori, R., Muldoon, M. F., Neumann, S. A., Ryan, C. M., Flory, J. D., & Manuck, S. B. (2006) · Psychosomatic Medicine · doi:10.1097/01.psy.0000238451.22174.92 · Cited by 182
Executive Decline and Dysfunction Precedes Declines in Memory: The Women's Health and Aging Study II
Carlson, M. C., Xue, Q., Zhou, J., & Fried, L. P. (2009) · The Journals of Gerontology Series A · doi:10.1093/gerona/gln008 · Cited by 160
C-reactive protein is related to memory and medial temporal brain volume in older adults
Bettcher, B. M., Wilheim, R., Rigby, T., Green, R., Miller, J. W., Racine, C. A., Yaffe, K. S., Miller, B. L., & Kramer, J. H. (2011) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2011.07.240 · Cited by 147
Circulating interleukin‐6 concentration and cognitive decline in old age: the PROSPER study
Mooijaart, S. P., Sattar, N. A., Trompet, S., Lucke, J., Stott, D. J., Ford, I., Jukema, J. W., Westendorp, R. G. J., & de Craen, A. J. M. (2013) · Journal of Internal Medicine · doi:10.1111/joim.12052 · Cited by 116
Serum high sensitivity C-reactive protein and cognitive function in elderly women
Komulainen, P., Lakka, T. A., Kivipelto, M., Hassinen, M., Penttila, I. M., Helkala, E.-L., Gylling, H. K., Nissinen, A. M., & Rauramaa, R. (2007) · Age and Ageing · doi:10.1093/ageing/afm051 · Cited by 115
Inflammation-associated declines in cerebral vasoreactivity and cognition in type 2 diabetes
Chung, C., Maldonado, D. P., Jor’dan, A. J., Hao, Y., Milberg, W., & Novak, V. (2015) · Neurology · doi:10.1212/wnl.0000000000001820 · Cited by 110
Spira, D., Buchmann, N., Nikolov, J., Demuth, I., Steinhagen‐Thiessen, E., Eckardt, R., & Norman, K. (2015) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu246 · Cited by 94
Self-citationHoth, K. F., Haley, A. P., Gunstad, J., Paul, R. H., Poppas, A., Jefferson, A. L., Tate, D. F., Ono, M., Jerskey, B. A., & Cohen, R. A. (2008) · Journal of the American Geriatrics Society · doi:10.1111/j.1532-5415.2008.01930.x · Cited by 64
Associations Between Inflammation and Cognitive Function in African Americans and European Americans
Windham, B. G., Simpson, B. N., Lirette, S. T., Bridges, J. M., Bielak, L. F., Peyser, P. A., Kullo, I. J., Turner, S. T., Griswold, M. E., & Mosley, T. H. (2014) · Journal of the American Geriatrics Society · doi:10.1111/jgs.13165 · Cited by 60
Peripheral Inflammation and Cognitive Aging
Lim, A., Krajina, K., & Marsland, A. L. (2013) · Modern trends in psychiatry · doi:10.1159/000346362 · Cited by 57
Ahmadi‐Abhari, S., Luben, R., Wareham, N. J., & Khaw, K. (2013) · European Journal of Clinical Investigation · doi:10.1111/eci.12116 · Cited by 38
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Liu, X., Ma, Y., Ouyang, R., Zeng, Z., Zhan, Z., Lu, H., Cui, Y., Dai, Z., Luo, L., He, C., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01905-2 · Cited by 249
Sungkarat, S., Boripuntakul, S., Kumfu, S., Lord, S., & Chattipakorn, N. (2018) · Neurorehabilitation and Neural Repair · doi:10.1177/1545968317753682 · Cited by 167
Tang, Y., Fung, E., Xu, A., & Lan, H. Y. (2017) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.12758 · Cited by 146
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Lin, T., Liu, G. A., Perez, E., Rainer, R. D., Febo, M., Cruz-Almeida, Y., & Ebner, N. C. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00236 · Cited by 138
Metadata
- Authors
- Tegeler, C., O'Sullivan, J. L., Bucholtz, N., Goldeck, D., Pawelec, G., Steinhagen-Thiessen, E., & Demuth, I.
- Affiliations
- Charité – Universitätsmedizin Berlin (DE)
- University of Tübingen (DE)
- Corresponding author
- Tegeler, Christina
- Demuth, Ilja
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 38
- Pages
- 112-117
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2167109574
- Cited by
- 163
- References
- 42
- Citations by year
- 2026: 14 · 2025: 19 · 2024: 23 · 2023: 20 · 2022: 14 · 2021: 19 · 2020: 18 · 2019: 13 · 2018: 10 · 2017: 7 · 2016: 6
- FWCI
- 6.23
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Bundesministerium für Bildung und Forschung (16SV5536K)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- C-reactive protein, interleukin-6, IL-10, inflammation, cognitive function, executive function, processing speed, verbal episodic memory, cognitive decline, older adults, innate immune system
- MeSH terms
- Aged, Aged, 80 and over, C-Reactive Protein, Cognition, Female, Humans, Immunity, Innate, Male, Middle Aged, Interleukin-6, Linear Models, Interleukin-10, Inflammation Mediators, Executive Function
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