Excessive tau accumulation in the parieto-occipital cortex characterizes early-onset Alzheimer's disease
Open accessAbstract
Early-onset Alzheimer's disease (EOAD) is characterized by greater nonmemory dysfunctions, more rapid progression, and greater hypometabolism and atrophy than late-onset AD (LOAD). We sought to investigate the differences in tau accumulation patterns between early- and late-onset patients with AD and mild cognitive impairment (MCI). In 90 patients who completed 18 F-AV-1451 and 18 F-florbetaben positron emission tomography scans, only 59 amyloid-positive patients (11 EOAD, 10 EOMCI, 21 LOAD, and 17 LOMCI) were included in this study. We compared cortical 18 F-AV-1451 binding between each patient group and corresponding amyloid-negative age-matched controls. In contrast to no difference in cortical binding between the EOMCI and LOMCI groups, EOAD showed greater binding in the parieto-occipital cortex than LOAD. The parieto-occipital binding correlated with visuospatial dysfunction in the EOAD spectrum, whereas binding in the temporal cortex correlated with verbal memory dysfunction in the LOAD spectrum. Our findings suggest that distinct topographic distribution of tau may influence the nature of cognitive impairment in EOAD patients.
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Elevated tau PET binding in medial temporal lobe structures and neocortex is strongly associated with positive amyloid PET scans and with clinical impairment across the normal aging to dementia clinical spectrum.
“Elevated tau PET binding in both medial temporal lobe structures and the neocortex is strongly associated with positive amyloid PET scans and with clinical impairment across the normal aging to dementia clinical spectrum [82,130–141].”
From NIA‐AA Research Framework: Toward a biological definition of Alzheimer's disease (2018) · cites this paper as [135]
Recent tau PET studies with [18F]flortaucipir showed that EOAD had greater tau burden in the neocortex compared to LOAD patients.
“Recent tau PET studies with [18F]flortaucipir showed that EOAD had greater tau burden in the neocortex compared to LOAD patients (Cho et al., 2017; Schöll et al., 2017).”
From Effects of Alzheimer’s and Vascular Pathologies on Structural Connectivity in Early- and Late-Onset Alzheimer’s Disease (2021) · cites this paper as Cho et al., 2017
Greater tau burden exists in the parieto-occipital area with EOAD patients compared to LOAD.
“consistently with previous researches reporting that greater tau burden exists in the parieto-occipital area with EOAD patients compared to LOAD (Cho et al., 2017).”
From Effects of Alzheimer’s and Vascular Pathologies on Structural Connectivity in Early- and Late-Onset Alzheimer’s Disease (2021) · cites this paper as Cho et al., 2017
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- Authors
- Cho, H., Choi, J. Y., Lee, S. H., Lee, J. H., Choi, Y.-C., Ryu, Y. H., Lee, M. S., & Lyoo, C. H.
- Affiliations
- Yonsei University (KR)
- Corresponding author
- Lyoo, Chul Hyoung
- ORCID
- Venue
- Neurobiology of Aging
- Publisher
- Elsevier BV
- Published
- 2017-05
- Volume
- 53
- Pages
- 103-111
- ISSN
- 0197-4580 (ISSN-L)
- OpenAlex
- W2586227379
- Cited by
- 83
- References
- 9
- Citations by year
- 2026: 8 · 2025: 5 · 2024: 10 · 2023: 10 · 2022: 9 · 2021: 11 · 2020: 6 · 2019: 10 · 2018: 12 · 2017: 2
- FWCI
- 6.77
- Type
- journal article
- Language
- en
- Open access
- Licence
- cc-by-nc-nd
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- Locations
- Neurobiology of Aging (publishedVersion)
- PubMed (publishedVersion)
- YUHSpace (Yonsei University Medical Library) (submittedVersion, cc-by-nc-nd)
- Funders
- National Research Foundation of Korea
- Ministry of Science, ICT and Future Planning (2015R1C1A2A01054507)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- early-onset Alzheimer's disease, late-onset Alzheimer's disease, tau accumulation, parieto-occipital cortex, 18F-AV-1451, 18F-florbetaben, amyloid PET, mild cognitive impairment, visuospatial impairment
- MeSH terms
- Aged, Aged, 80 and over, Alzheimer Disease, Cognition, Female, Humans, Male, Memory, Middle Aged, Occipital Lobe, Parietal Lobe, Spatial Behavior, Verbal Behavior, Visual Perception, tau Proteins, Positron-Emission Tomography, Cognitive Dysfunction
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