Age-related changes in the default mode network are more advanced in Alzheimer disease
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OBJECTIVE: To investigate age-related default mode network (DMN) connectivity in a large cognitively normal elderly cohort and in patients with Alzheimer disease (AD) compared with age-, gender-, and education-matched controls. METHODS: We analyzed task-free-fMRI data with both independent component analysis and seed-based analysis to identify anterior and posterior DMNs. We investigated age-related changes in connectivity in a sample of 341 cognitively normal subjects. We then compared 28 patients with AD with 56 cognitively normal noncarriers of the APOE ε4 allele matched for age, education, and gender. RESULTS: The anterior DMN shows age-associated increases and decreases in fontal lobe connectivity, whereas the posterior DMN shows mainly age-associated declines in connectivity throughout. Relative to matched cognitively normal controls, subjects with AD display an accelerated pattern of the age-associated changes described above, except that the declines in frontal lobe connectivity did not reach statistical significance. These changes survive atrophy correction and are correlated with cognitive performance. CONCLUSIONS: The results of this study indicate that the DMN abnormalities observed in patients with AD represent an accelerated aging pattern of connectivity compared with matched controls.
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Abnormalities in the default mode network have been observed in AD patients.
“Furthermore, abnormalities in the default mode network, which is regulated in part by PV-INs [27], have been observed in AD patients [28][29][30][31][32].”
From Parvalbumin interneuron vulnerability and brain disorders (2021) · cites this paper as [28]
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- Authors
- Jones, D. T., Machulda, M. M., Vemuri, P., McDade, E. M., Zeng, G., Senjem, M. L., Gunter, J. L., Przybelski, S. A., Avula, R. T., Knopman, D. S., Boeve, B. F., Petersen, R. C., & Jack, C. R.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Jack, C.R.
- ORCID
- Venue
- Neurology
- Published
- 2011-10-18
- Volume
- 77
- Issue
- 16
- Pages
- 1524-1531
- ISSN
- 0028-3878 (ISSN-L)
- 1526-632X
- PMC
- PMC3198977
- OpenAlex
- W2064066094
- Cited by
- 370
- References
- 30
- Citations by year
- 2026: 11 · 2025: 22 · 2024: 27 · 2023: 20 · 2022: 27 · 2021: 34 · 2020: 24 · 2019: 31 · 2018: 24 · 2017: 26 · 2016: 24 · 2015: 25 · 2014: 29 · 2013: 23 · 2012: 23
- FWCI
- 12.17
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Neurology (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Eli Lilly and Company
- Pfizer
- Baxter International
- Mayo Foundation for Medical Education and Research (AG16574)
- University of Oxford
- Eisai
- National Institutes of Health (AG11378, R01 AG11378, AG16574)
- National Institute on Aging (R01AG11378, P50‐AG16574, U01AG06786, AG 16574, U01AG006786, R01AG011378, AG-11378, P50AG016574)
- National Center for Research Resources (C06RR018898)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- default mode network, Alzheimer's disease, brain aging, functional connectivity, posterior default mode network, frontal lobe connectivity, APOE ε4, cognitive performance, brain atrophy, accelerated aging
- MeSH terms
- Age Factors, Aged, Aged, 80 and over, Aging, Alzheimer Disease, Brain, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Net, Neural Pathways, Neuropsychological Tests, Oxygen, Psychiatric Status Rating Scales, Cohort Studies, Statistics, Nonparametric
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