Cited by 65Dementia and Cognitive Impairment ResearchAdvanced Neuroimaging Techniques and ApplicationsAlzheimer's disease research and treatments

Neurofilament relates to white matter microstructure in older adults

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Moore, Elizabeth E., Hohman, Timothy J., Badami, Faizan S., Pechman, Kimberly R., Osborn, Katie E., Acosta, Lealani Mae Y., Bell, Susan P., Babicz, Michelle A. +6 more·2018·Neurobiology of Aging

Abstract

Cerebrospinal fluid (CSF) neurofilament light (NFL) is a protein biomarker of axonal injury. To study whether NFL is associated with diffusion tensor imaging (DTI) measurements of white matter (WM) microstructure, Vanderbilt Memory & Aging Project participants with normal cognition (n = 77), early mild cognitive impairment (n = 15), and MCI (n = 55) underwent lumbar puncture to obtain CSF and 3T brain MRI. Voxel-wise analyses cross-sectionally related NFL to DTI metrics, adjusting for demographic and vascular risk factors. Increased NFL correlated with multiple DTI metrics (p-values < 0.05). An NFL × diagnosis interaction (excluding early mild cognitive impairment) on WM microstructure (p-values < 0.05) was detected, with associations strongest among MCI. Multiple NFL × CSF biomarker interactions were detected. Associations between NFL and worse WM metrics were strongest among amyloid-β 42-negative, tau-positive, and suspected nonamyloid pathology participants. Findings suggest increased NFL, a biomarker of axonal injury, is correlated with compromised WM microstructure. Results highlight the role of elevated NFL in predicting WM damage in cognitively impaired older adults who are amyloid-negative, tau-positive, or meet suspected nonamyloid pathology criteria.

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Crossref · 10.1016/j.neurobiolaging.2018.06.023

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  • Existing evidence from human studies strongly supports the relationship between raised NFL levels and WM microstructure damage.

    “Existing evidence from human studies strongly support the relationship between raised NFL levels and WM microstructure damage (Moore et al., 2018, Osborn et al., 2018).”

    From Disrupted structural connectivity in ArcAβ mouse model of Aβ amyloidosis (2020) · cites this paper as Moore et al., 2018

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Authors
Moore, E. E., Hohman, T. J., Badami, F. S., Pechman, K. R., Osborn, K. E., Acosta, L. M. Y., Bell, S. P., Babicz, M. A., Gifford, K. A., Anderson, A. W., Goldstein, L. E., Blennow, K., Zetterberg, H., & Jefferson, A. L.
Affiliations
  • Vanderbilt University Medical Center (US)
  • University of Houston (US)
  • Vanderbilt University (US)
  • Boston University (US)
  • Sahlgrenska University Hospital (SE)
Corresponding author
Jefferson, Angela L.
Venue
Neurobiology of Aging
Publisher
Elsevier BV
Published
2018-10
Volume
70
Pages
233-241
ISSN
0197-4580 (ISSN-L)
OpenAlex
W2811179428
Cited by
65
References
42
Citations by year
2026: 3 · 2025: 3 · 2024: 13 · 2023: 3 · 2022: 9 · 2021: 13 · 2020: 14 · 2019: 6 · 2018: 1
FWCI
6.69
Type
journal article
Language
en
Open access
Locations
  • Neurobiology of Aging (acceptedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
  • Vanderbilt University
  • Sahlgrenska Universitetssjukhuset
  • National Institutes of Health (1s10od023680-01, UL1TR000445, UL1TR002243)
  • National Institute on Aging (R01AG056534, K24AG046373, K23AG030962, K23AG045966, K23AG048347, K01AG049164, F32AG058395, R01AG034962)
  • National Institute of General Medical Sciences (T32GM007347)
  • National Institute of Neurological Disorders and Stroke (R01NS100980)
  • National Center for Advancing Translational Sciences
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (U54HD083211)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
Keywords
neurofilament light chain, white matter microstructure, axonal injury, mild cognitive impairment, diffusion tensor imaging, cerebrospinal fluid biomarkers, amyloid-beta 42, tau protein, older adults, cognitive aging
MeSH terms
Aged, Aging, Brain, Female, Humans, Magnetic Resonance Imaging, Male, Peptide Fragments, Cohort Studies, Biomarkers, Amyloid beta-Peptides, Neurofilament Proteins, Diffusion Tensor Imaging, Cognitive Dysfunction, White Matter

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