The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Diffusion tensor imaging detects early Wallerian degeneration of the pyramidal tract after ischemic stroke
Abstract
We used diffusion tensor imaging (DTI) to assess Wallerian degeneration of the pyramidal tract within the first 2 weeks after ischemic stroke, and correlated the extent of Wallerian degeneration with the motor deficit. Nine patients with middle cerebral artery stroke were examined 2-16 days after stroke by DTI and T2-weighted MRI. We measured fractional anisotropy (FA), averaged diffusivity (Dav), eigenvalues of the diffusion tensor and T2-weighted signal in the cerebral peduncle and compared these values between the affected and the unaffected side and between patients and six controls. FA was significantly reduced on the affected side compared to the unaffected side and compared to the control group. The largest eigenvalue was reduced, whereas the smallest eigenvalue was elevated on the affected side. There was no significant difference in T2-weighted signal and Dav. The decrease of anisotropy correlated positively with the motor deficit at the time of DTI study and 90 days after stroke. The reduction of anisotropy mirrors the disintegration of axonal structures, as it occurs in the early phase of Wallerian degeneration. DTI detects changes of water diffusion related to beginning pyramidal tract degeneration within the first 2 weeks after stroke that are not yet visible in conventional T2-weighted or orientationally averaged diffusion weighted MRI. We demonstrated for the first time a correlation of early DTI findings of pyramidal tract damage with the motor deficit. DTI can help prognosing recovery of motor function after stroke within the early subacute phase.
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“Changes in FA signal one or many microstructural alterations, such as Wallerian degeneration (Pierpaoli et al., 2001; Thomalla et al., 2004) or decreased neuronal membrane permeability (Jones, KnöSche, & Turner, 2013).”
From Substance abuse and white matter: Findings, limitations, and future of diffusion tensor imaging research (2019) · cites this paper as Thomalla et al., 2004
Citations
Cites
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The basis of anisotropic water diffusion in the nervous system—A technical review.
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Self-citationBasser, P. J., & Pierpaoli, C. (1996) · Journal of Magnetic Resonance, Series B · doi:10.1006/jmrb.1996.0086 · Cited by 4,306
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Basser, P. J., Mattiello, J., & Bihan, D. L. (1994) · Journal of Magnetic Resonance Series B · doi:10.1006/jmrb.1994.1037 · Cited by 3,656
Diffusion tensor imaging: Concepts and applications
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Diffusion tensor MR imaging of the human brain
Pierpaoli, C., Jezzard, P., Basser, P. J., Barnett, A., & Di Chiro, G. (1996) · Radiology · doi:10.1148/radiology.201.3.8939209 · Cited by 2,664
Dysmyelination revealed through MRI as increased radial (but unchanged axial) diffusion of water
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Water diffusion changes in wallerian degeneration and their dependence on white matter architecture
Pierpaoli, C., Barnett, A., Pajevic, S., Chen, R., Penix, L., Virta, A., & Basser, P. (2001) · NeuroImage · doi:10.1006/nimg.2001.0765 · Cited by 938
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Diffusion tensor imaging (DTI)-based white matter mapping in brain research: a review
Assaf, Y., & Pasternak, O. (2008) · Journal of Molecular Neuroscience · doi:10.1007/s12031-007-0029-0 · Cited by 1,537
“MS (Gd enhanced) 0.44±0.12 N/A −22 Bammer et al. 2000 MS (corpus callosum) 0.75±0.06 0.79±0.05 −13 Bammer et al. 2000 MS (ring enhanced) 0.23±0.01 N/A −38 Bammer et al. 2000 MS (centrum semiovale) 0.46±0.06 0.53±0.07 −5 Bammer et al. 2000 MS 0.39±0.11 0.54±0.15 −28 Assaf and Cohen 2002 MS 0.52±0.15 0.54±0.15 −4 Assaf…”
InfluentialFunctional potential in chronic stroke patients depends on corticospinal tract integrity
Stinear, C. M., Barber, P. A., Smale, P., Coxon, J. P., Fleming, M. K., & Byblow, W. D. (2006) · Brain · doi:10.1093/brain/awl333 · Cited by 864
“Studies that have examined small homogeneous samples of subcortical stroke patients have found that larger asymmetries in FA are associated with poorer motor reco- very (Watanabe et al., 2001; Thomalla et al., 2004; Jang et al., 2005).”
BackgroundMethodResultInfluentialSidaros, A., Engberg, A. W., Sidaros, K., Liptrot, M. G., Herning, M., Petersen, P., Paulson, O. B., Jernigan, T. L., & Rostrup, E. (2007) · Brain · doi:10.1093/brain/awm294 · Cited by 526
“Regardless of the exact proportionate contribution of these pathological processes, the observed DTI pattern is consistent with Wallerian or Wallerian-like degeneration (Pierpaoli et al., 2001; Thomalla et al., 2004), most likely reflecting consequences of DAI and/or secondary hypoxic–ischaemic injury.”
ResultBennett, I. J., Madden, D. J., Vaidya, C. J., Howard, D. V., & Howard, J. H. (2009) · Human Brain Mapping · doi:10.1002/hbm.20872 · Cited by 512
“One interpretation of age-related decreases in AD can be inferred from previous research on the effect of ischemic stroke on DTI-based measures of white matter integrity in humans (Pierpaoli et al., 2001; Thomalla et al., 2004) and mice (Song et al.”
Diffusion tensor imaging of cerebral white matter integrity in cognitive aging
Madden, D. J., Bennett, I. J., Burzynska, A. Z., Potter, G. G., Chen, N., & Song, A. W. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.08.003 · Cited by 510
“This type of diffusivity pattern has been observed in secondary (Wallerian) degeneration, which is the degeneration, over time, of axon fibers distal to the point of transsection or injury [36–37, 40–42].”
Background
Metadata
- Authors
- Thomalla, G., Glauche, V., Koch, M. A., Beaulieu, C., Weiller, C., & Röther, J.
- Affiliations
- University Medical Center Hamburg-Eppendorf (DE)
- University of Alberta (CA)
- Corresponding author
- Thomalla, Götz
- ORCID
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2004-08
- Volume
- 22
- Issue
- 4
- Pages
- 1767-1774
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2059177186
- Cited by
- 438
- References
- 46
- Citations by year
- 2026: 9 · 2025: 10 · 2024: 13 · 2023: 15 · 2022: 12 · 2021: 24 · 2020: 15 · 2019: 17 · 2018: 15 · 2017: 16 · 2016: 23 · 2015: 18 · 2014: 33 · 2013: 25 · 2012: 21
- FWCI
- 18.44
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Health Sciences › Medicine › Clinical Neurology › Acute Ischemic Stroke Management
- Health Sciences › Medicine › Rehabilitation › Stroke Rehabilitation and Recovery
- Keywords
- Wallerian degeneration, corticospinal tract, ischemic stroke, middle cerebral artery stroke, diffusion tensor imaging, fractional anisotropy, motor impairment, cerebral peduncle
- MeSH terms
- Aged, Axons, Dominance, Cerebral, Female, Humans, Image Processing, Computer-Assisted, Male, Middle Aged, Movement Disorders, Neurologic Examination, Prognosis, Pyramidal Tracts, Reference Values, Statistics as Topic, Wallerian Degeneration, Anisotropy, Infarction, Middle Cerebral Artery, Diffusion Magnetic Resonance Imaging
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