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Stability of amygdala BOLD response to fearful faces over multiple scan sessions
Abstract
We used fMRI to examine amygdala activation in response to fearful facial expressions, measured over multiple scanning sessions. 15 human subjects underwent three scanning sessions, at 0, 2 and 8 weeks. During each session, functional brain images centered about the amygdala were acquired continuously while participants were shown alternating blocks of fearful, neutral and happy facial expressions. Intraclass correlation coefficients calculated across the sessions indicated stability of response in left amygdala to fearful faces (as a change from baseline), but considerably less left amygdala stability in responses to neutral expressions and for fear versus neutral contrasts. The results demonstrate that the measurement of fMRI BOLD responses in amygdala to fearful facial expressions might be usefully employed as an index of amygdala reactivity over extended periods. While signal change to fearful facial expressions appears robust, the experimental design employed here has yielded variable responsivity within baseline or comparison conditions. Future studies might manipulate the experimental design to either amplify or attenuate this variability, according to the goals of the research.
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“For example, Johnstone et al. (2005) achieved high test-retest reliability for the amygdala across three measurement occasions over two months yet found that reliability was affected by such characteristics as usage of percent signal change vs. z scores, ROIs that were structurally vs. empirically defined, as well as different theoretically sound contrasts (e.g., the contrast of viewing fearful”
From Adolescent neurobiological susceptibility to social context (2016) · cites this paper as Johnstone et al., 2005
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Metadata
- Authors
- Johnstone, T., Somerville, L. H., Alexander, A. L., Oakes, T. R., Davidson, R. J., Kalin, N. H., & Whalen, P. J.
- Affiliations
- University of Wisconsin System (US)
- Corresponding author
- Johnstone, Tom
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2005-05
- Volume
- 25
- Issue
- 4
- Pages
- 1112-1123
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W1977246716
- Cited by
- 155
- References
- 40
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 3 · 2023: 4 · 2022: 6 · 2021: 2 · 2020: 6 · 2019: 5 · 2018: 3 · 2017: 8 · 2016: 8 · 2015: 10 · 2014: 6 · 2013: 12 · 2012: 11
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Swinburne figshare (Swinburne University of Technology) (submittedVersion)
- Funders
- U.S. Public Health Service (069315, 67167)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Face Recognition and Perception
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- amygdala, BOLD signal, fearful faces, facial expressions, amygdala reactivity, intraclass correlation coefficient, measurement reliability, emotional face processing
- MeSH terms
- Adult, Amygdala, Anxiety, Facial Expression, Fear, Female, Humans, Image Processing, Computer-Assisted, Functional Laterality, Magnetic Resonance Imaging, Male, Middle Aged, Models, Neurological, Oxygen, Psychiatric Status Rating Scales, Reproducibility of Results, Linear Models
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