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Dynamics of male sexual arousal: distinct components of brain activation revealed by fMRI
Abstract
The peripheral mechanisms of male sexual arousal are well known. Recently, neuroimaging techniques, such as PET or fMRI, allowed the investigation of the subjacent cerebral mechanisms. In ten healthy subjects, we have simultaneously recorded fMRI images of brain activation elicited by viewing erotic scenes, and the time course of penile tumescence by means of a custom-built MRI-compatible pneumatic cuff. We have compared activation elicited by video clips with a long duration, that led to sexual arousal and penile erection, and activation elicited by briefly presented still images, that did induce sexual arousal without erection. This comparison and the use of the time course of penile tumescence in video clips allowed to perform a time resolved data analysis and to correlate different patterns of brain activation with different phases of sexual response. The activation maps highlighted a complex neural circuit involved in sexual arousal. Of this circuit, only a few areas (anterior cingulate, insula, amygdala, hypothalamus, and secondary somatosensory cortices) were specifically correlated with penile erection. Finally, these areas showed distinct dynamic relationships with the time course of sexual response. These differences might correspond to different roles in the development and appraisal of the sexual response. These findings shed light on the psychophysiology of male sexuality and open new perspectives for the diagnosis, therapy, and possible rehabilitation of sexual…
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“Both men and women experiencing visually-induced sexual arousal show increased activity in the amygdala, hippocampus, mPFC, NAc, OFC, ACC, and IC [129,130,131,132].”
From The Neurobiology of Love and Pair Bonding from Human and Animal Perspectives (2023) · cites this paper as [131]
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Metadata
- Authors
- Ferretti, A., Caulo, M., Del Gratta, C., Di Matteo, R., Merla, A., Montorsi, F., Pizzella, V., Pompa, P., Rigatti, P., Rossini, P. M., Salonia, A., Tartaro, A., & Romani, G. L.
- Affiliations
- University of Chieti-Pescara (IT)
- Vita-Salute San Raffaele University (IT)
- Ospedale SS. Annunziata (IT)
- Università Campus Bio-Medico (IT)
- Corresponding author
- Ferretti, Antonio
- ORCID
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2005-07
- Volume
- 26
- Issue
- 4
- Pages
- 1086-1096
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2021586194
- Cited by
- 288
- References
- 35
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 5 · 2023: 12 · 2022: 11 · 2021: 11 · 2020: 11 · 2019: 11 · 2018: 16 · 2017: 24 · 2016: 17 · 2015: 18 · 2014: 10 · 2013: 22 · 2012: 21
- FWCI
- 7.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Archivio Istituzionale della Ricerca - Università Vita-Salute San Raffaele (submittedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Social Sciences › Psychology › Clinical Psychology › Sexuality, Behavior, and Technology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Keywords
- male sexual arousal, penile tumescence, brain activation, anterior cingulate cortex, insula, amygdala, hypothalamus, secondary somatosensory cortex, sexual dysfunction
- MeSH terms
- Adult, Brain, Brain Mapping, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Nerve Net, Oxygen, Penile Erection, Photic Stimulation, Sexual Behavior
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