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Cited by 533Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsFunctional Brain Connectivity Studies

The DOI matches its Crossref record; 47 of the 49 references it cites were found in a registry or an index.

Using voxel-based morphometry to map the structural changes associated with rapid conversion in MCI: A longitudinal MRI study

Chételat, G., Landeau, B., Eustache, F., Mézenge, F., Viader, F., de la Sayette, V., Desgranges, B., Baron, J.-C.·2005·NeuroImage
DOI 10.1016/j.neuroimage.2005.05.015
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Abstract

Capturing the dynamics of gray matter (GM) atrophy in relation to the conversion from mild cognitive impairment (MCI) to clinically probable Alzheimer's disease (AD) would be of considerable interest. In this prospective study we have used a novel longitudinal voxel-based method to map the progression of GM loss in MCI patients over time and compared converters to non-converters. Eighteen amnestic MCI patients were followed-up for a predefined fixed period of 18 months and conversion was judged according to NINCDS-ADRDA criteria for probable AD. Each patient underwent a high-resolution T1-weighted volume MRI scan both at entry in the study and 18 months later. We used an optimal VBM protocol to compare baseline imaging data of converters to those of non-converters. Moreover, to map GM loss from baseline to follow-up assessment, we used a modified voxel-based morphometry (VBM) procedure specially designed for longitudinal studies. At the end of the follow-up period, seven patients had converted to probable AD. Areas of lower baseline GM value in converters mainly included the hippocampus, parahippocampal cortex, and lingual and fusiform gyri. Regions of significant GM loss over the 18-month follow-up period common to both converters and non-converters included the temporal neocortex, parahippocampal cortex, orbitofrontal and inferior parietal areas, and the left thalamus. However, there was significantly greater GM loss in converters relative to non-converters in the hippocampal area, inferior and middle temporal gyrus, posterior cingulate, and precuneus. This accelerated atrophy may result from both neurofibrillary tangles accumulation and parallel pathological processes such as functional alteration in the posterior cingulate. The ability to longitudinally assess GM changes in MCI offers new perspectives to better understand the pathological processes underlying AD and to monitor the effects of treatment on brain structure.

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Crossref · 10.1016/j.neuroimage.2005.05.015

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Research works printed but not linked: 1

  1. Yamada, 1996, Longitudinal neuropsychological and quantitative MRI assessments in early Alzheimer's disease, Alzheimer's Res., 2, 29

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Metadata

Authors
Chételat, G., Landeau, B., Eustache, F., Mézenge, F., Viader, F., de la Sayette, V., Desgranges, B., & Baron, J.-C.
Affiliations
  • Inserm (FR)
  • Centre National de la Recherche Scientifique (FR)
  • University of Cambridge (GB)
Corresponding author
Chételat, G.
ORCID
Venue
NeuroImage
Publisher
Elsevier BV
Published
2005-10
Volume
27
Issue
4
Pages
934-946
ISSN
1053-8119 (ISSN-L)
DOI
10.1016/j.neuroimage.2005.05.015
OpenAlex
W1970300450
Cited by
526
References
49
Citations by year
2026: 1 · 2025: 5 · 2024: 19 · 2023: 7 · 2022: 16 · 2021: 19 · 2020: 15 · 2019: 17 · 2018: 21 · 2017: 25 · 2016: 28 · 2015: 24 · 2014: 31 · 2013: 31 · 2012: 35
FWCI
18.81
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Institut National de la Santé et de la Recherche Médicale
  • Institut de Recherches Servier
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
mild cognitive impairment, conversion to Alzheimer's disease, gray matter atrophy, voxel-based morphometry, hippocampus, parahippocampal cortex, posterior cingulate cortex, precuneus, temporal lobe atrophy, thalamus, neurofibrillary tangles, treatment monitoring
MeSH terms
Aged, Alzheimer Disease, Amnesia, Atrophy, Brain, Brain Mapping, Cognition Disorders, Female, Humans, Image Interpretation, Computer-Assisted, Functional Laterality, Longitudinal Studies, Magnetic Resonance Imaging, Male, Middle Aged, Neuropsychological Tests, Disease Progression

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