CoChat
Sign Up
Cited by 249Attention Deficit Hyperactivity DisorderNeurotransmitter Receptor Influence on BehaviorNeural and Behavioral Psychology Studies

The DOI matches its Crossref record; 67 of the 73 references it cites were found in a registry or an index.

Brain dopamine transporter levels in treatment and drug naive adults with ADHD

Volkow, Nora D., Wang, Gene-Jack, Newcorn, Jeffrey, Fowler, Joanna S., Telang, Frank, Solanto, Mary V., Logan, Jean, Wong, Christopher, Ma, Yeming, Swanson, James M., Schulz, Kurt, Pradhan, Kith·2007·NeuroImage
DOI 10.1016/j.neuroimage.2006.10.014
Open this paper in CoChat — free account

Abstract

Attention deficit hyperactivity disorder (ADHD) is the most frequent psychiatric disorder in children, yet data are sparse on its pathophysiology. Particularly relevant are the dopamine transporters since these are the main targets of stimulant medications used for ADHD treatment. Though some imaging studies have shown increases in dopamine transporters in ADHD others have not and their role in the neurobiology of ADHD remains unclear. Here we investigate dopamine transporters in ADHD subjects with control of potentially confounding factors (previous medication and/or drug histories, comorbidity) and their association with clinical symptoms. Positron emission tomography and [11C]cocaine were used to measure dopamine transporters in 20 never medicated adults with ADHD and 25 controls. Dopamine transporters were lower in left caudate (13%, p < 0.05) and in left nucleus accumbens (p < 0.005) in ADHD subjects than in controls. In putamen dopamine transporters did not differ between groups but were associated with scores of inattention (Conners Adult Attention Rating Scale) both in ADHD subjects (p < 0.005) and in controls (p < 0.005). Thus, for a given transporter level the scores for inattention were on average five times greater in ADHD subjects than in controls. These results do not corroborate increases in dopamine transporters in ADHD subjects and show that in some they are reduced. It also provides evidence that dopamine transporter levels modulate attention but suggest that additional pathology (e.g., prefrontal or cingulostriatal pathways, noradrenergic neurotransmission) is necessary to account for the large differences in inattention observed between controls and ADHD subjects.

Overview

Integrity signals

Registry

Crossref · 10.1016/j.neuroimage.2006.10.014

Cites

67 of 67 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 73 references

6 of the 73 references couldn’t be matched to a known paper.

Research works printed but not linked: 3

  1. Conners, 1998, Rating scales in attention-deficit/hyperactivity disorder: use in assessment and treatment monitoring, J. Clin. Psychiatry, 59, 24
  2. Hesse, 2006, The striatal dopamine transporter availability is reduced in adults with attention-deficit/hyperactivity disorder, J. Nucl. Med., 47, 142
  3. National Institutes of Health (NIH), 2000, Consensus Development Conference Statement: diagnosis and treatment of attention deficit/hyperactivity disorder (ADHD), J. Am. Acad. Child Adolesc. Psych., 39, 192

Cited by

Sorted by citations

Items 201–249 of 249

Related

See all

Metadata

Authors
Volkow, N. D., Wang, G.-J., Newcorn, J., Fowler, J. S., Telang, F., Solanto, M. V., Logan, J., Wong, C., Ma, Y., Swanson, J. M., Schulz, K., & Pradhan, K.
Affiliations
  • National Institute on Drug Abuse (US)
  • Brookhaven National Laboratory (US)
  • Mount Sinai Hospital (US)
  • National Institute on Alcohol Abuse and Alcoholism (US)
  • University of California, Irvine (US)
  • State University of New York (US)
Corresponding author
Volkow, Nora D.
ORCID
Venue
NeuroImage
Publisher
Elsevier BV
Published
2007-02
Volume
34
Issue
3
Pages
1182-1190
ISSN
1053-8119 (ISSN-L)
DOI
10.1016/j.neuroimage.2006.10.014
OpenAlex
W2082738856
Cited by
249
References
73
Citations by year
2026: 5 · 2025: 7 · 2024: 9 · 2023: 7 · 2022: 9 · 2021: 7 · 2020: 11 · 2019: 4 · 2018: 12 · 2017: 10 · 2016: 11 · 2015: 13 · 2014: 24 · 2013: 14 · 2012: 22
FWCI
11.29
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of Mental Health (MH66961-02, R01MH066961)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
attention deficit hyperactivity disorder, dopamine transporter, caudate nucleus, nucleus accumbens, putamen, inattention, adult ADHD, neurobiology of ADHD, noradrenergic neurotransmission
MeSH terms
Adult, Central Nervous System Stimulants, Attention Deficit Disorder with Hyperactivity, Brain, Carbon Radioisotopes, Cocaine, Female, Humans, Male, Tissue Distribution, Radiopharmaceuticals, Positron-Emission Tomography, Dopamine Plasma Membrane Transport Proteins

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review