Fiber density asymmetry of the arcuate fasciculus in relation to functional hemispheric language lateralization in both right- and left-handed healthy subjects: a combined fMRI and DTI study
Abstract
Previously reported leftward asymmetry in language-related gray and white matter areas of the brain has been proposed as a structural correlate of left-sided functional hemispheric language lateralization. However, structural asymmetry in non-left-sided functional language lateralization has as yet not been studied. Furthermore, the neuroanatomical basis of the reported volumetric white matter asymmetry is not fully understood. In 20 healthy volunteers, including 13 left-handers, we performed functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI). We studied the relative fiber density (RFD) of the arcuate fasciculus (AF), using DT-tractography, in relation to functional hemispheric language lateralization. Hemispheric language lateralization was right-sided in five left-handed individuals. We demonstrated an overall significant leftward asymmetry in RFD of the AF, irrespective of handedness or functional language lateralization. Furthermore, in right-handers, the degree of structural asymmetry was found to be correlated with the degree of functional lateralization. We conclude that structural asymmetry in the AF does not seem to reflect functional hemispheric language lateralization, as has been proposed previously. Our findings suggest that the previously reported white matter asymmetry may be explained by a structural asymmetry in the arcuate fasciculus. These findings have important implications for the understanding of the functional and structura…
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The lateralization of SLF II subcomponents is dominant in the left hemisphere.
“other researchers found the SLF II subcomponents' lateralization to be dominant in the left hemisphere (7, 56, 72).”
From Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates (2022) · cites this paper as [72]
Cites
A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains
Good, C. D., Johnsrude, I. S., Ashburner, J., Henson, R. N. A., Friston, K. J., & Frackowiak, R. S. J. (2001) · NeuroImage · doi:10.1006/nimg.2001.0786 · Cited by 4,561 · see citing works
Diffusion tensor MR imaging of the human brain
Pierpaoli, C., Jezzard, P., Basser, P. J., Barnett, A., & Di Chiro, G. (1996) · Radiology · doi:10.1148/radiology.201.3.8939209 · Cited by 2,664 · see citing works
Tuch, D. S. (2004) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20279 · Cited by 1,880 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Thiebaut de Schotten, M., ffytche, D. H., Bizzi, A., Dell'Acqua, F., Allin, M., Walshe, M., Murray, R., Williams, S. C., Murphy, D. G. M., & Catani, M. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.07.055 · Cited by 656 · see citing works
Choi, J., Jeong, B., Rohan, M. L., Polcari, A. M., & Teicher, M. H. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.06.022 · Cited by 376 · see citing works
Alcohol, psychological dysregulation, and adolescent brain development
Clark, D. B., Thatcher, D. L., & Tapert, S. F. (2008) · Alcoholism: Clinical and Experimental Research · doi:10.1111/j.1530-0277.2007.00601.x · Cited by 222 · see citing works
Quantitative tract-based white matter development from birth to age 2 years
Geng, X., Gouttard, S., Sharma, A., Gu, H., Styner, M., Lin, W., Gerig, G., & Gilmore, J. H. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2012.03.057 · Cited by 212 · see citing works
Choi, J., Jeong, B., Polcari, A., Rohan, M. L., & Teicher, M. H. (2012) · NeuroImage · doi:10.1016/j.neuroimage.2011.09.033 · Cited by 215 · see citing works
Superior Longitudinal Fasciculus: A Review of the Anatomical Descriptions With Functional Correlates
Janelle, F., Iorio-Morin, C., D'amour, S., & Fortin, D. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.794618 · Cited by 189 · see citing works
Hecht, E. E., Gutman, D. A., Bradley, B. A., Preuss, T. M., & Stout, D. (2015) · NeuroImage · doi:10.1016/j.neuroimage.2014.12.039 · Cited by 175 · see citing works
“Note that this is in contrast to the arcuate fasciculus, which is left-lateralized both in humans (Nucifora et al., 2005; Vernooij et al., 2007; Glasser and Rilling, 2008) and chimpanzees (Rilling et al.”
Abnormal Language Pathway in Children With Angelman Syndrome
Wilson, B. J., Sundaram, S. K., Huq, A. H. M., Jeong, J.-W., Halverson, S. R., Behen, M. E., Bui, D. Q., & Chugani, H. T. (2011) · Pediatric Neurology · doi:10.1016/j.pediatrneurol.2010.12.002 · Cited by 60 · see citing works
Anatomical variability of the arcuate fasciculus: a systematical review
Bernard, F., Zemmoura, I., Ter Minassian, A., Lemée, J.-M., & Menei, P. (2019) · Surgical and Radiologic Anatomy · doi:10.1007/s00276-019-02244-5 · Cited by 55 · see citing works
- Authors
- Vernooij, M. W., Smits, M., Wielopolski, P. A., Houston, G. C., Krestin, G. P., & van der Lugt, A.
- Affiliations
- Erasmus MC (NL)
- Corresponding author
- Vernooij, M.W.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2007-04
- Volume
- 35
- Issue
- 3
- Pages
- 1064-1076
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2149479555
- Cited by
- 316
- References
- 3
- Citations by year
- 2026: 10 · 2025: 14 · 2024: 11 · 2023: 11 · 2022: 6 · 2021: 18 · 2020: 16 · 2019: 16 · 2018: 11 · 2017: 27 · 2016: 17 · 2015: 19 · 2014: 22 · 2013: 27 · 2012: 12
- FWCI
- 8.33
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Hemispheric Asymmetry in Neuroscience
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Keywords
- arcuate fasciculus, handedness, tractography, right-handedness, left-handedness, language functions
- MeSH terms
- Adult, Arcuate Nucleus of Hypothalamus, Brain Mapping, Female, Humans, Language, Functional Laterality, Magnetic Resonance Imaging, Male, Middle Aged, Nerve Fibers, Myelinated, Neural Pathways, Speech
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
