The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Structural correlates of psychopathological symptom dimensions in schizophrenia: A voxel-based morphometric study
Abstract
Structural neuroimaging has substantially advanced the neurobiological research of schizophrenia by describing a range of focal brain alterations as possible neuroanatomical underpinnings of the disease. Despite this progress, a considerable heterogeneity of structural findings persists that may reflect the phenomenological diversity of schizophrenia. It is unclear whether the range of possible clinical disease manifestations relates to a core structural brain deficit or to distinct structural correlates. Therefore, gray matter density (GMD) differences between 175 schizophrenic patients (SZ) and 177 matched healthy control subjects (HC) were examined in a three-step approach using cross-sectional and conjunctional voxel-based morphometry (VBM): (1) analysis of structural alterations irrespective of symptomatology; (2) subdivision of the patient sample according to a three-dimensional factor model of the PANSS and investigation of structural differences between these subsamples and healthy controls; (3) analysis of a common pattern of structural alterations present in all patient subsamples compared to healthy controls. Significant GMD reductions in patients compared to controls were identified within the prefrontal, limbic, paralimbic, temporal and thalamic regions. The disorganized symptom dimension was associated with bilateral alterations in temporal, insular and medial prefrontal cortices. Positive symptoms were associated with left-pronounced alterations in perisylvian regions and extended thalamic GMD losses. Negative symptoms were linked to the most extended alterations within orbitofrontal, medial prefrontal, lateral prefrontal and temporal cortices as well as limbic and subcortical structures. Thus, structural heterogeneity in schizophrenia may relate to specific patterns of GMD reductions that possibly share a common prefrontal-perisylvian pattern of structural brain alterations.
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Citations
Cites
The Positive and Negative Syndrome Scale (PANSS) for schizophrenia.
Kay, S. R., Fiszbein, A., & Opler, L. A. (1987) · Schizophrenia Bulletin · doi:10.1093/schbul/13.2.261 · Cited by 21,378
A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains
Good, C. D., Johnsrude, I. S., Ashburner, J., Henson, R. N. A., Friston, K. J., & Frackowiak, R. S. J. (2001) · NeuroImage · doi:10.1006/nimg.2001.0786 · Cited by 4,561
A review of MRI findings in schizophrenia
Shenton, M. E., Dickey, C. C., Frumin, M., & McCarley, R. W. (2001) · Schizophrenia Research · doi:10.1016/s0920-9964(01)00163-3 · Cited by 2,346
Abnormal monitoring of inner speech: a physiological basis for auditory hallucinations
McGuire, P. K., David, A. S., Murray, R. M., Frackowiak, R. S. J., Frith, C. D., Wright, I., & Silbersweig, D. A. (1995) · The Lancet · doi:10.1016/s0140-6736(95)91435-8 · Cited by 349 · cited 1×
“Finally, all these findings including our own results are consistent with functional neuroimaging studies showing an impaired activation of temporal areas involved in the monitoring of inner speech (McGuire et al., 1995; Dierks et al., 1999).”
ResultSanfilipo, M., Lafargue, T., Rusinek, H., Arena, L., Loneragan, C., Lautin, A., Feiner, D., Rotrosen, J., & Wolkin, A. (2000) · Archives of General Psychiatry · doi:10.1001/archpsyc.57.5.471 · Cited by 281
Cited by
Anatomy of bipolar disorder and schizophrenia: A meta-analysis
Ellison-Wright, I., & Bullmore, E. (2010) · Schizophrenia Research · doi:10.1016/j.schres.2009.12.022 · Cited by 565
Palaniyappan, L., & Liddle, P. F. (2012) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.100176 · Cited by 548
Koutsouleris, N., Davatzikos, C., Borgwardt, S., Gaser, C., Bottlender, R., Frodl, T., Falkai, P., Riecher-Rossler, A., Moller, H.-J., Reiser, M., et al. (2014) · Schizophrenia Bulletin · doi:10.1093/schbul/sbt142 · Cited by 448
Self-citationAbnormal asymmetries in subcortical brain volume in schizophrenia
COCORO, Okada, N., Fukunaga, M., Yamashita, F., Koshiyama, D., Yamamori, H., Ohi, K., Yasuda, Y., Fujimoto, M., Watanabe, Y., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.209 · Cited by 369
Brain Heterogeneity in Schizophrenia and Its Association With Polygenic Risk
Alnæs, D., Kaufmann, T., van der Meer, D., Córdova-Palomera, A., Rokicki, J., Moberget, T., Bettella, F., Agartz, I., Barch, D. M., Bertolino, A., et al. (2019) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2019.0257 · Cited by 264
Metadata
- Authors
- Koutsouleris, N., Gaser, C., Jäger, M., Bottlender, R., Frodl, T., Holzinger, S., Schmitt, G. J. E., Zetzsche, T., Burgermeister, B., Scheuerecker, J., Born, C., Reiser, M., Möller, H.-J., & Meisenzahl, E. M.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2008-02
- Volume
- 39
- Issue
- 4
- Pages
- 1600-1612
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2108053280
- Cited by
- 190
- References
- 5
- FWCI
- 4.00
- Type
- journal article
- Language
- en
- Open access
- closed
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- Koutsouleris, N., Gaser, C., Jäger, M., Bottlender, R., Frodl, T., Holzinger, S., Schmitt, G. J. E., Zetzsche, T., Burgermeister, B., Scheuerecker, J., Born, C., Reiser, M., Möller, H.-J., & Meisenzahl, E. M. (2008). Structural correlates of psychopathological symptom dimensions in schizophrenia: A voxel-based morphometric study. NeuroImage. https://doi.org/10.1016/j.neuroimage.2007.10.029
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