Cited by 172Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsFunctional Brain Connectivity Studies

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Antemortem MRI based STructural Abnormality iNDex (STAND)-scores correlate with postmortem Braak neurofibrillary tangle stage

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Vemuri, Prashanthi, Whitwell, Jennifer L., Kantarci, Kejal, Josephs, Keith A., Parisi, Joseph E., Shiung, Maria S., Knopman, David S., Boeve, Bradley F., Petersen, Ronald C., Dickson, Dennis W., Jack, Clifford R.·2008·NeuroImage

DOI 10.1016/j.neuroimage.2008.05.012PMC PMC3097053

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Abstract

The clinical diagnosis of Alzheimer's disease (AD) does not exactly match the pathological findings at autopsy in every subject. Therefore, in-vivo imaging measures, such as Magnetic Resonance Imaging (MRI) that reflect underlying pathology, would be clinically useful independent supplementary measures of disease stage. We have developed an algorithm that extracts atrophy information from individual patient's 3D MRI scans and assigns a STructural Abnormality iNDex (STAND)-score to the scan based on the degree of atrophy in comparison to patterns extracted from a large library of clinically well characterized AD and CN (cognitively normal) subject's MRI scans. STAND-scores can be adjusted for demographics to give adjusted-STAND (aSTAND)-scores which are >0 for subjects with brains identified as abnormal by the algorithm. Since histopathological findings are considered to represent the "ground truth", our objective was to assess the sensitivity of aSTAND-scores to pathological AD staging. This was done by comparing antemortem MRI based aSTAND-scores with postmortem grading of disease severity in 101 subjects who had both antemortem MRI and postmortem Braak neurofibrillary tangle (NFT) staging. We found a rank correlation of 0.62 (p<0.0001) between Braak NFT stage and aSTAND-scores. The results show that optimally extracted information from MRI scans such as STAND-scores accurately capture the severity of neuronal pathology and can be used as an independent approximate surrogate marker for in-vivo pathological staging as well as for early identification of AD in individual subjects.

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Authors: Vemuri, P., Whitwell, J. L., Kantarci, K., Josephs, K. A., Parisi, J. E., Shiung, M. S., Knopman, D. S., Boeve, B. F., Petersen, R. C., Dickson, D. W., & Jack, C. R.
Affiliations: Mayo Clinic (US)
Corresponding author: Jack, Clifford R.
ORCID: Vemuri, Prashanthi
Whitwell, Jennifer L.
Kantarci, Kejal
Josephs, Keith A.
Knopman, David S.
Boeve, Bradley F.
Petersen, Ronald C.
Dickson, Dennis W.
Jack, Clifford R.
Venue: NeuroImage
Publisher: Elsevier BV
Published: 2008-08
Volume: 42
Issue: 2
Pages: 559-567
ISSN: 1053-8119 (ISSN-L)
DOI: 10.1016/j.neuroimage.2008.05.012
PMC: PMC3097053
OpenAlex: W1990502495
Cited by: 172
References: 60
Citations by year: 2026: 3 · 2025: 4 · 2024: 4 · 2023: 3 · 2022: 6 · 2021: 11 · 2020: 9 · 2019: 7 · 2018: 8 · 2017: 9 · 2016: 14 · 2015: 11 · 2014: 16 · 2013: 15 · 2012: 13
FWCI: 9.14
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: NeuroImage (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute on Aging (R01AG11378, K23AG030935, P50‐AG16574, R01 AG06786, U01AG006786, R01AG011378, P50AG016574)
National Center for Research Resources (KL2RR024151, K12RR24151, C06RR018898)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords: Alzheimer's disease, neurofibrillary tangles, Braak staging, brain atrophy, postmortem neuropathology, disease staging, early detection of Alzheimer's disease
MeSH terms: Alzheimer Disease, Brain, Diagnosis, Female, Humans, Magnetic Resonance Imaging, Male, Sensitivity and Specificity, Severity of Illness Index, Statistics as Topic, Reproducibility of Results, Neurofibrillary Tangles, Imaging, Three-Dimensional

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Antemortem MRI based STructural Abnormality iNDex (STAND)-scores correlate with postmortem Braak neurofibrillary tangle stage

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