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The role of the nucleus accumbens and rostral anterior cingulate cortex in anhedonia: Integration of resting EEG, fMRI, and volumetric techniques

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Wacker, Jan, Dillon, Daniel G., Pizzagalli, Diego A.·2009·NeuroImage

DOI 10.1016/j.neuroimage.2009.01.058PMC PMC2686061

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Abstract

Anhedonia, the reduced propensity to experience pleasure, is a promising endophenotype and vulnerability factor for several psychiatric disorders, including depression and schizophrenia. In the present study, we used resting electroencephalography, functional magnetic resonance imaging, and volumetric analyses to probe putative associations between anhedonia and individual differences in key nodes of the brain's reward system in a non-clinical sample. We found that anhedonia, but not other symptoms of depression or anxiety, was correlated with reduced nucleus accumbens (NAcc) responses to rewards (gains in a monetary incentive delay task), reduced NAcc volume, and increased resting delta current density (i.e., decreased resting activity) in the rostral anterior cingulate cortex (rACC), an area previously implicated in positive subjective experience. In addition, NAcc reward responses were inversely associated with rACC resting delta activity, supporting the hypothesis that delta might be lawfully related to activity within the brain's reward circuit. Taken together, these results help elucidate the neural basis of anhedonia and strengthen the argument for anhedonia as an endophenotype for depression.

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Authors: Wacker, J., Dillon, D. G., & Pizzagalli, D. A.
Affiliations: Harvard University (US)
Corresponding author: Pizzagalli, Diego A.
ORCID: Wacker, Jan
Dillon, Daniel G.
Pizzagalli, Diego A.
Venue: NeuroImage
Publisher: Elsevier BV
Published: 2009-05-15
Volume: 46
Issue: 1
Pages: 327-337
ISSN: 1053-8119 (ISSN-L)
DOI: 10.1016/j.neuroimage.2009.01.058
PMC: PMC2686061
OpenAlex: W2102857043
Cited by: 405
References: 101
Citations by year: 2026: 8 · 2025: 18 · 2024: 16 · 2023: 20 · 2022: 39 · 2021: 26 · 2020: 23 · 2019: 22 · 2018: 20 · 2017: 20 · 2016: 28 · 2015: 35 · 2014: 29 · 2013: 25 · 2012: 25
FWCI: 12.30
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: NeuroImage (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Funders: National Institute of Mental Health (R01MH068376, R01 MH68376)
National Center for Complementary and Integrative Health (R21AT002974)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: anhedonia, nucleus accumbens, rostral anterior cingulate cortex, reward processing, endophenotypes, depression, schizophrenia, reward systems, individual differences, brain volume
MeSH terms: Adult, Affect, Anxiety, Depression, Electroencephalography, Female, Gyrus Cinguli, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Nucleus Accumbens, Reward, Signal Processing, Computer-Assisted

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The role of the nucleus accumbens and rostral anterior cingulate cortex in anhedonia: Integration of resting EEG, fMRI, and volumetric techniques

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