Cited by 406Neural and Behavioral Psychology StudiesNeurotransmitter Receptor Influence on BehaviorTreatment of Major Depression

The DOI matches its Crossref record; 101 of the 101 references it cites were found in a registry or an index.

The role of the nucleus accumbens and rostral anterior cingulate cortex in anhedonia: Integration of resting EEG, fMRI, and volumetric techniques

Open access

Wacker, Jan, Dillon, Daniel G., Pizzagalli, Diego A.·2009·NeuroImage

DOI 10.1016/j.neuroimage.2009.01.058PMC PMC2686061

Open this paper in CoChat — free account

Abstract

Anhedonia, the reduced propensity to experience pleasure, is a promising endophenotype and vulnerability factor for several psychiatric disorders, including depression and schizophrenia. In the present study, we used resting electroencephalography, functional magnetic resonance imaging, and volumetric analyses to probe putative associations between anhedonia and individual differences in key nodes of the brain's reward system in a non-clinical sample. We found that anhedonia, but not other symptoms of depression or anxiety, was correlated with reduced nucleus accumbens (NAcc) responses to rewards (gains in a monetary incentive delay task), reduced NAcc volume, and increased resting delta current density (i.e., decreased resting activity) in the rostral anterior cingulate cortex (rACC), an area previously implicated in positive subjective experience. In addition, NAcc reward responses were inversely associated with rACC resting delta activity, supporting the hypothesis that delta might be lawfully related to activity within the brain's reward circuit. Taken together, these results help elucidate the neural basis of anhedonia and strengthen the argument for anhedonia as an endophenotype for depression.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.neuroimage.2009.01.058

Cites

101 of 101 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Development and validation of brief measures of positive and negative affect: The PANAS scales.
Watson, D., Clark, L. A., & Tellegen, A. (1988) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.54.6.1063 · Cited by 32,433
An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest
Desikan, R. S., Ségonne, F., Fischl, B., Quinn, B. T., Dickerson, B. C., Blacker, D., Buckner, R. L., Dale, A. M., Maguire, R. P., Hyman, B. T., et al. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.01.021 · Cited by 13,324
The Brain's Default Network: Anatomy, Function, and Relevance to Disease
Buckner, R. L., Andrews‐Hanna, J. R., & Schacter, D. L. (2008) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1440.011 · Cited by 9,761
Whole Brain Segmentation
Fischl, B., Salat, D. H., Busa, E., Albert, M., Dieterich, M., Haselgrove, C., van der Kouwe, A., Killiany, R., Kennedy, D., Klaveness, S., et al. (2002) · Neuron · doi:10.1016/s0896-6273(02)00569-x · Cited by 8,610
Cognitive and emotional influences in anterior cingulate cortex
Bush, G., Luu, P., & Posner, M. I. (2000) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01483-2 · Cited by 6,259
Tests for comparing elements of a correlation matrix
Steiger, J. H. (1980) · Psychological Bulletin · doi:10.1037/0033-2909.87.2.245 · Cited by 4,621 · cited 1×
“Differences between dependent correlation coefficients were tested using the formula proposed by Steiger (1980).”
Method
Predictive reward signal of dopamine neurons
Schultz, W. (1998) · Journal of Neurophysiology · doi:10.1152/jn.1998.80.1.1 · Cited by 4,564
Automatically Parcellating the Human Cerebral Cortex
Fischl, B. R. (2003) · Cerebral Cortex · doi:10.1093/cercor/bhg087 · Cited by 4,208
Functional neuroanatomy of emotion: A meta-analysis of emotion activation studies in PET and fMRI
Phan, K. L., Wager, T., Taylor, S. F., & Liberzon, I. (2002) · NeuroImage · doi:10.1006/nimg.2002.1087 · Cited by 3,502
Electroencephalography—Basic principles, clinical applications and related fields
(1982) · Journal of the Autonomic Nervous System · doi:10.1016/0165-1838(82)90067-4 · Cited by 3,449

Show all 101 references

Research works printed but not linked: 1

Chang AY Kuo TB Tsai TH Chen CF Chan SH 1995 Power spectral analysis of electroencephalographic desynchronization induced by cocaine in rats: correlation with evaluation of noradrenergic neurotransmission at the medial prefrontal cortex Synapse 21 149 157 8584976

Sorted by citations

Reconsidering anhedonia in depression: Lessons from translational neuroscience
Treadway, M. T., & Zald, D. H. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.06.006 · Cited by 1,579
Annual research review: enduring neurobiological effects of childhood abuse and neglect
Teicher, M. H., & Samson, J. A. (2016) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12507 · Cited by 1,473
Childhood adversity and neural development: Deprivation and threat as distinct dimensions of early experience
McLaughlin, K. A., Sheridan, M. A., & Lambert, H. K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.10.012 · Cited by 1,389
The neurobiology of anhedonia and other reward-related deficits
Der-Avakian, A., & Markou, A. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.11.005 · Cited by 1,130
Neural circuits underlying the pathophysiology of mood disorders
Price, J. L., & Drevets, W. C. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.12.011 · Cited by 788
EEG delta oscillations as a correlate of basic homeostatic and motivational processes
Knyazev, G. G. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2011.10.002 · Cited by 776
Linking Molecules to Mood: New Insight Into the Biology of Depression
Krishnan, V., & Nestler, E. J. (2010) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2009.10030434 · Cited by 666
Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression
Felger, J. C., Li, Z., Haroon, E., Woolwine, B. J., Jung, M. Y., Hu, X., & Miller, A. H. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.168 · Cited by 620
Inflammation-Induced Anhedonia: Endotoxin Reduces Ventral Striatum Responses to Reward
Eisenberger, N. I., Berkman, E. T., Inagaki, T. K., Rameson, L. T., Mashal, N. M., & Irwin, M. R. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2010.06.010 · Cited by 596
Cognitive Mechanisms of Treatment in Depression
Roiser, J. P., Elliott, R., & Sahakian, B. J. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.183 · Cited by 535
Ventral striatal and medial prefrontal BOLD activation is correlated with reward-related electrocortical activity: A combined ERP and fMRI study
Carlson, J. M., Foti, D., Mujica-Parodi, L. R., Harmon‐Jones, E., & Hajcak, G. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2011.05.037 · Cited by 490
Consumer neuroscience: Assessing the brain response to marketing stimuli using electroencephalogram (EEG) and eye tracking
Khushaba, R. N., Wise, C., Kodagoda, S., Louviere, J. J., Kahn, B. E., & Townsend, C. (2013) · Expert Systems with Applications · doi:10.1016/j.eswa.2012.12.095 · Cited by 505
Anhedonia predicts poorer recovery among youth with selective serotonin reuptake inhibitor treatment-resistant depression
McMakin, D. L., Olino, T. M., Porta, G., Dietz, L. J., Emslie, G., Clarke, G., Wagner, K. D., Asarnow, J. R., Ryan, N. D., Birmaher, B., et al. (2012) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2012.01.011 · Cited by 448
Sex differences in anxiety and depression: circuits and mechanisms
Bangasser, D. A., & Cuarenta, A. (2021) · Nature Reviews Neuroscience · doi:10.1038/s41583-021-00513-0 · Cited by 479
Annual Research Review: Childhood maltreatment, latent vulnerability and the shift to preventative psychiatry – the contribution of functional brain imaging
McCrory, E. J., Gerin, M. I., & Viding, E. (2017) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12713 · Cited by 402
Treatment for Anhedonia: A Neuroscience Driven Approach: 2015 ADAA Scientific Research Symposium: Treatment for Anhedonia
Craske, M. G., Meuret, A. E., Ritz, T., Treanor, M., & Dour, H. J. (2016) · Depression and Anxiety · doi:10.1002/da.22490 · Cited by 387
The Brain’s Response to Reward Anticipation and Depression in Adolescence: Dimensionality, Specificity, and Longitudinal Predictions in a Community-Based Sample
Stringaris, A., Vidal-Ribas Belil, P., Artiges, E., Lemaitre, H., Gollier-Briant, F., Wolke, S., Vulser, H., Miranda, R., Penttilä, J., Struve, M., et al. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.14101298 · Cited by 322
Structural and synaptic plasticity in stress-related disorders
Christoffel, D. J., Golden, S. A., & Russo, S. J. (2011) · Reviews in the Neurosciences · doi:10.1515/rns.2011.044 · Cited by 334
Reward processing and mood-related symptoms: An RDoC and translational neuroscience perspective
Nusslock, R., & Alloy, L. B. (2017) · Journal of Affective Disorders · doi:10.1016/j.jad.2017.02.001 · Cited by 342
Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings
Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299
Reward circuitry function in autism spectrum disorders
Dichter, G. S., Felder, J. N., Green, S. R., Rittenberg, A. M., Sasson, N. J., & Bodfish, J. W. (2012) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsq095 · Cited by 296
Hyporeactivity of ventral striatum towards incentive stimuli in unmedicated depressed patients normalizes after treatment with escitalopram
Stoy, M., Schlagenhauf, F., Sterzer, P., Bermpohl, F., Hägele, C., Suchotzki, K., Schmack, K., Wrase, J., Ricken, R., Knutson, B., et al. (2012) · Journal of Psychopharmacology · doi:10.1177/0269881111416686 · Cited by 279
The C factor: cognitive dysfunction as a transdiagnostic dimension in psychopathology
Abramovitch, A., Short, T., & Schweiger, A. (2021) · Clinical Psychology Review · doi:10.1016/j.cpr.2021.102007 · Cited by 269
Dopamine, behavioral economics, and effort
Salamone, J. D. (2009) · Frontiers in Behavioral Neuroscience · doi:10.3389/neuro.08.013.2009 · Cited by 277
Prefrontal direct current stimulation modulates resting EEG and event-related potentials in healthy subjects: A standardized low resolution tomography (sLORETA) study
Keeser, D., Padberg, F., Reisinger, E., Pogarell, O. M., Kirsch, V., Palm, U., Karch, S., Möller, H. ‐., Nitsche, M. A., & Mulert, C. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.12.004 · Cited by 287
Structural Brain Development and Depression Onset During Adolescence: A Prospective Longitudinal Study
Whittle, S., Lichter, R., Dennison, M., Vijayakumar, N., Schwartz, O., Byrne, M. L., Simmons, J. G., Yücel, M., Pantelis, C., McGorry, P. D., et al. (2014) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2013.13070920 · Cited by 266
Event-related delta and theta synchronization during explicit and implicit emotion processing
Knyazev, G. G., Slobodskoj‐Plusnin, J. Y., & Bocharov, A. V. (2009) · Neuroscience · doi:10.1016/j.neuroscience.2009.09.057 · Cited by 253
A randomized proof-of-mechanism trial applying the ‘fast-fail’ approach to evaluating κ-opioid antagonism as a treatment for anhedonia
Krystal, A. D., Pizzagalli, D. A., Smoski, M., Mathew, S. J., Nurnberger, J., Lisanby, S. H., Iosifescu, D., Murrough, J. W., Yang, H., Weiner, R. D., et al. (2020) · Nature Medicine · doi:10.1038/s41591-020-0806-7 · Cited by 227
Self-citation
Reduced nucleus accumbens reactivity and adolescent depression following early-life stress
Goff, B., Gee, D. G., Telzer, E. H., Humphreys, K. L., Gabard-Durnam, L., Flannery, J., & Tottenham, N. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2012.12.010 · Cited by 234
Sex differences in antidepressant efficacy
LeGates, T. A., Kvarta, M. D., & Thompson, S. M. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0156-z · Cited by 242
Reconceptualizing anhedonia: novel perspectives on balancing the pleasure networks in the human brain
Thomsen, K. R., Whybrow, P. C., & Kringelbach, M. L. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00049 · Cited by 256
The role of cytokines in the pathophysiology of suicidal behavior
Ganança, L., Oquendo, M. A., Tyrka, A. R., Cisneros-Trujillo, S., Mann, J. J., & Sublette, M. E. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.10.008 · Cited by 217
A Short Review on the Current Understanding of Autism Spectrum Disorders
Park, H. R., Lee, J. M., Moon, H. E., Lee, D. S., Kim, B.-N., Kim, J., Kim, D. G., & Paek, S. H. (2016) · Experimental Neurobiology · doi:10.5607/en.2016.25.1.1 · Cited by 243
Reward dysfunction in major depression: Multimodal neuroimaging evidence for refining the melancholic phenotype
Foti, D., Carlson, J. M., Sauder, C. L., & Proudfit, G. H. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.06.058 · Cited by 217
Relationships among cognition, emotion, and motivation: implications for intervention and neuroplasticity in psychopathology
Crocker, L. D., Heller, W., Warren, S. L., O'Hare, A. J., Infantolino, Z. P., & Miller, G. A. (2013) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2013.00261 · Cited by 193
The research domain criteria framework: The case for anterior cingulate cortex
Holroyd, C. B., & Umemoto, A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.09.021 · Cited by 187
Stratified medicine for mental disorders
Schumann, G., Binder, E. B., Holte, A., de Kloet, E. R., Oedegaard, K. J., Robbins, T. W., Walker-Tilley, T. R., Bitter, I., Brown, V. J., Buitelaar, J., et al. (2014) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2013.09.010 · Cited by 186
Anhedonia and Emotional Experience in Schizophrenia: Neural and Behavioral Indicators
Dowd, E. C., & Barch, D. M. (2010) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.10.020 · Cited by 184
The role of inflammation in core features of depression: Insights from paradigms using exogenously-induced inflammation.
Dooley, L. N., Kuhlman, K. R., Robles, T. F., Eisenberger, N. I., Craske, M. G., & Bower, J. E. (2018) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2018.09.006 · Cited by 176
Role of Reward Sensitivity and Processing in Major Depressive and Bipolar Spectrum Disorders
Alloy, L. B., Olino, T. M., Freed, R. D., & Nusslock, R. (2016) · Behavior Therapy · doi:10.1016/j.beth.2016.02.014 · Cited by 188
A review of white matter microstructure alterations of pathways of the reward circuit in depression
Bracht, T., Linden, D. E. J., & Keedwell, P. A. (2015) · Journal of Affective Disorders · doi:10.1016/j.jad.2015.06.041 · Cited by 178
Imaging Genetics and Genomics in Psychiatry: A Critical Review of Progress and Potential
Bogdan, R., Salmeron, B. J., Carey, C. E., Arpana Agrawal, A., Calhoun, V. D., Garavan, H., Hariri, A. R., Heinz, A., Hill, M. N., Holmes, A., et al. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2016.12.030 · Cited by 174
Helping Depressed Clients Reconnect to Positive Emotion Experience: Current Insights and Future Directions
Dunn, B. D. (2012) · Clinical Psychology & Psychotherapy · doi:10.1002/cpp.1799 · Cited by 168
Altered neural reward and loss processing and prediction error signalling in depression
Ubl, B., Kuehner, C., Kirsch, P., Ruttorf, M., Diener, C., & Flor, H. (2015) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsu158 · Cited by 165
Cholinergic interneurons in the nucleus accumbens regulate depression-like behavior
Warner-Schmidt, J. L., Schmidt, E. F., Marshall, J. J., Rubin, A. J., Arango-Lievano, M., Kaplitt, M. G., Ibañez-Tallon, I., Heintz, N., & Greengard, P. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1209293109 · Cited by 163
Deep brain stimulation targets for treating depression
Drobisz, D., & Damborská, A. (2018) · Behavioural Brain Research · doi:10.1016/j.bbr.2018.11.004 · Cited by 164
Pavlovian Reward Prediction and Receipt in Schizophrenia: Relationship to Anhedonia
Dowd, E. C., & Barch, D. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0035622 · Cited by 154
The Default Mode Network and EEG Regional Spectral Power: A Simultaneous fMRI-EEG Study
Neuner, I., Arrubla, J., Werner, C. J., Hitz, K., Boers, F., Kawohl, W., & Shah, N. J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088214 · Cited by 166
Trait anhedonia is associated with reduced reactivity and connectivity of mesolimbic and paralimbic reward pathways
Keller, J., Young, C. B., Kelley, E., Prater, K. E., Levitin, D. J., & Menon, V. (2013) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2013.05.015 · Cited by 144
Positive affect treatment targets reward sensitivity: A randomized controlled trial.
Craske, M. G., Meuret, A. E., Echiverri-Cohen, A. M., Rosenfield, D., & Ritz, T. (2023) · Journal of Consulting and Clinical Psychology · doi:10.1037/ccp0000805 · Cited by 152
Visualization of the medial forebrain bundle using diffusion tensor imaging
Hana, A., Hana, A., Dooms, G., Boecher-Schwarz, H., & Hertel, F. (2015) · Frontiers in Neuroanatomy · doi:10.3389/fnana.2015.00139 · Cited by 137
Challenges and opportunities for drug discovery in psychiatric disorders: the drug hunters' perspective
Wong, E. H. F., Yocca, F. D., Smith, M. A., & Lee, C. (2010) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145710000866 · Cited by 139
Schizotypy as An Organizing Framework for Social and Affective Sciences
Cohen, A. S., Möhr, C., Ettinger, U., Chan, R. C. K., & Park, S. (2015) · Schizophrenia Bulletin · doi:10.1093/schbul/sbu195 · Cited by 140
Microstructural Abnormalities in Subcortical Reward Circuitry of Subjects with Major Depressive Disorder
Blood, A. J., Iosifescu, D. V., Makris, N., Perlis, R. H., Kennedy, D. N., Dougherty, D. D., Kim, B. W., Lee, M. J., Wu, S., Lee, S., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013945 · Cited by 126
Anhedonia revisited: Is there a role for dopamine-targeting drugs for depression?
Argyropoulos, S. V., & Nutt, D. (2013) · Journal of Psychopharmacology · doi:10.1177/0269881113494104 · Cited by 127
Anhedonia, depressed mood, and smoking cessation outcome.
Leventhal, A. M., Piper, M. E., Japuntich, S. J., Baker, T. B., & Cook, J. W. (2013) · Journal of Consulting and Clinical Psychology · doi:10.1037/a0035046 · Cited by 125
BIS/BAS, cortical oscillations and coherence in response to emotional cues
Balconi, M., Brambilla, E., & Falbo, L. (2009) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2009.07.001 · Cited by 125
Cross-frequency coupling of brain oscillations in studying motivation and emotion
Schutter, D. J. L. G., & Knyazev, G. G. (2011) · Motivation and Emotion · doi:10.1007/s11031-011-9237-6 · Cited by 131
Social reward in youth at risk for depression: a preliminary investigation of subjective and neural differences
Olino, T. M., Silk, J. S., Osterritter, C., & Forbes, E. E. (2015) · Journal of Child and Adolescent Psychopharmacology · doi:10.1089/cap.2014.0165 · Cited by 122
The Nucleus Accumbens and Ketamine Treatment in Major Depressive Disorder
Abdallah, C. G., Jackowski, A., Salas, R., Gupta, S., Sato, J. R., Mao, X., Coplan, J. D., Shungu, D. C., & Mathew, S. J. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2017.49 · Cited by 123
Neurobehavioral markers of resilience to depression amongst adolescents exposed to child abuse
Dennison, M. J., Sheridan, M. A., Busso, D. S., Jenness, J. L., Peverill, M., Rosen, M. L., & McLaughlin, K. A. (2016) · Journal of Abnormal Psychology · doi:10.1037/abn0000215 · Cited by 117
Choice modeling and the brain: A study on the Electroencephalogram (EEG) of preferences
Khushaba, R. N., Greenacre, L., Kodagoda, S., Louviere, J. J., Burke, S. J., & Dissanayake, G. (2012) · Expert Systems with Applications · doi:10.1016/j.eswa.2012.04.084 · Cited by 116
Mood-congruent amygdala responses to subliminally presented facial expressions in major depression: associations with anhedonia
Stuhrmann, A., Dohm, K., Kugel, H., Zwanzger, P., Redlich, R., Grotegerd, D., Rauch, A. V., Arolt, V., Heindel, W., Suslow, T., et al. (2013) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.120060 · Cited by 112
Anhedonia and general distress show dissociable ventromedial prefrontal cortex connectivity in major depressive disorder
Young, C. B., Chen, T., Nusslock, R., Keller, J., Schatzberg, A. F., & Menon, V (2016) · Translational Psychiatry · doi:10.1038/tp.2016.80 · Cited by 108
Transcranial Magnetic Stimulation of the Left Dorsolateral Prefrontal Cortex Decreases Cue-induced Nicotine Craving and EEG Delta Power
Pripfl, J., Tomova, L., Riečanský, I., & Lamm, C. (2013) · Brain stimulation · doi:10.1016/j.brs.2013.11.003 · Cited by 110
A Reward-Based Framework of Perceived Control
Ly, V., Wang, K. S., Bhanji, J. P., & Delgado, M. R. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00065 · Cited by 117
Relations among EEG-alpha asymmetry, BIS/BAS, and dispositional optimism
Pascalis, V. D., Cozzuto, G., Caprara, G. V., & Alessandri, G. (2013) · Biological Psychology · doi:10.1016/j.biopsycho.2013.05.016 · Cited by 119
Delay discounting and future-directed thinking in anhedonic individuals
Lempert, K. M., & Pizzagalli, D. A. (2010) · Journal of Behavior Therapy and Experimental Psychiatry · doi:10.1016/j.jbtep.2010.02.003 · Cited by 105
Self-citation
Using fMRI to study reward processing in humans: past, present, and future
Wang, K. S., Smith, D. V., & Delgado, M. R. (2016) · Journal of Neurophysiology · doi:10.1152/jn.00333.2015 · Cited by 105
Cingulum White Matter in Young Women at Risk of Depression: The Effect of Family History and Anhedonia
Keedwell, P. A., Chapman, R., Christiansen, K., Richardson, H., Evans, J., & Jones, D. K. (2012) · Biological Psychiatry · doi:10.1016/j.biopsych.2012.01.022 · Cited by 108
Neural Correlates of Three Promising Endophenotypes of Depression: Evidence from the EMBARC Study
Webb, C. A., Dillon, D. G., Pechtel, P., Goer, F. K., Murray, L., Huys, Q. J., Fava, M., McGrath, P. J., Weissman, M., Parsey, R., et al. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2015.165 · Cited by 103
Self-citation
Overexpression of Adenosine A2A Receptors in Rats: Effects on Depression, Locomotion, and Anxiety
Coelho, J. E., Alves, P., Canas, P. M., Valadas, J. S., Shmidt, T., Batalha, V. L., Ferreira, D. G., Ribeiro, J. A., Bader, M., Cunha, R. A., et al. (2014) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2014.00067 · Cited by 102
Moderation of the relationship between reward expectancy and prediction error-related ventral striatal reactivity by anhedonia in unmedicated major depressive disorder: findings from the EMBARC study
Greenberg, T., Chase, H. W., Almeida, J. R., Stiffler, R., Zevallos, C. R., Aslam, H. A., Deckersbach, T., Weyandt, S., Cooper, C., Toups, M., et al. (2015) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2015.14050594 · Cited by 93
Resting EEG signatures of agentic extraversion: New results and meta-analytic integration
Wacker, J., Chavanon, M., & Stemmler, G. (2009) · Journal of Research in Personality · doi:10.1016/j.jrp.2009.12.004 · Cited by 106
Self-citation
Neural responses to negative feedback are related to negative emotionality in healthy adults
Santesso, D. L., Bogdan, R., Birk, J. L., Davis, E., Holmes, A. J., & Pizzagalli, D. A. (2011) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsr054 · Cited by 101
Self-citation
Neurons in the Ventral Striatum Exhibit Cell-Type-Specific Representations of Outcome during Learning
Atallah, H. E., McCool, A. D., Howe, M. W., & Graybiel, A. M. (2014) · Neuron · doi:10.1016/j.neuron.2014.04.021 · Cited by 103
A model for streamlining psychotherapy in the RDoC era: the example of ‘Engage’
Alexopoulos, G. S., & Arean, P. (2014) · Molecular Psychiatry · doi:10.1038/mp.2013.150 · Cited by 95
Subclinical depression severity is associated with distinct patterns of functional connectivity for subregions of anterior cingulate cortex
Philippi, C. L., Motzkin, J. C., Pujara, M. S., & Koenigs, M. (2015) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2015.10.005 · Cited by 93
Analogous responses in the nucleus accumbens and cingulate cortex to pain onset (aversion) and offset (relief) in rats and humans
Becerra, L. R., Navratilova, E., Porreca, F., & Borsook, D. (2013) · Journal of Neurophysiology · doi:10.1152/jn.00284.2013 · Cited by 99
Neural substrates of trait impulsivity, anhedonia, and irritability: Mechanisms of heterotypic comorbidity between externalizing disorders and unipolar depression
Zisner, A. R., & Beauchaine, T. P. (2016) · Development and Psychopathology · doi:10.1017/s0954579416000754 · Cited by 101
Identifying robust and sensitive frequency bands for interrogating neural oscillations
Shackman, A. J., McMenamin, B. W., Maxwell, J. S., Greischar, L. L., & Davidson, R. J. (2010) · NeuroImage · doi:10.1016/j.neuroimage.2010.03.037 · Cited by 92
Cross-frequency coupling of brain oscillations: An impact of state anxiety
Knyazev, G. G. (2011) · International Journal of Psychophysiology · doi:10.1016/j.ijpsycho.2011.03.013 · Cited by 91
Novel genome-wide associations for anhedonia, genetic correlation with psychiatric disorders, and polygenic association with brain structure
Ward, J., Lyall, L. M., Bethlehem, R. A. I., Ferguson, A., Strawbridge, R. J., Lyall, D. M., Cullen, B., Graham, N., Johnston, K. J. A., Bailey, M. E. S., et al. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0635-y · Cited by 83
Cortico-Cortical White Matter Motor Pathway Microstructure Is Related to Psychomotor Retardation in Major Depressive Disorder
Bracht, T., Federspiel, A., Schnell, S., Horn, H., Höfle, O., Wiest, R., Dierks, T., Strik, W. K., Müller, T., & Walther, S. (2012) · PLoS ONE · doi:10.1371/journal.pone.0052238 · Cited by 90
Reward Network Modulation as a Mechanism of Change in Behavioral Activation
Nagy, G. A., Cernasov, P., Pisoni, A., Walsh, E. C., Dichter, G. S., & Smoski, M. J. (2018) · Behavior Modification · doi:10.1177/0145445518805682 · Cited by 98
White matter microstructure alterations of the medial forebrain bundle in melancholic depression
Bracht, T., Horn, H., Strik, W. K., Federspiel, A., Schnell, S., Höfle, O., Stegmayer, K., Wiest, R., Dierks, T., Müller, T., et al. (2013) · Journal of Affective Disorders · doi:10.1016/j.jad.2013.10.048 · Cited by 90
Response inhibition and reward anticipation in medication‐naïve adults with attention‐deficit/hyperactivity disorder: A within‐subject case‐control neuroimaging study
Carmona, S., Hoekzema, E., Ramos‐Quiroga, J. A., Richarte, V., Canals, C., Bosch, R., Rovira, M., Carlos Soliva, J., Bulbena, A., Tobeña, A., et al. (2012) · Human Brain Mapping · doi:10.1002/hbm.21368 · Cited by 89
Using Multilevel Modeling to Examine Blunted Neural Responses to Reward in Major Depression
Brush, C. J., Ehmann, P. J., Hajcak, G., Selby, E. A., & Alderman, B. L. (2018) · Biological Psychiatry Cognitive Neuroscience and Neuroimaging · doi:10.1016/j.bpsc.2018.04.003 · Cited by 88
Frontal brain oscillations and social anxiety: A cross-frequency spectral analysis during baseline and speech anticipation
Miskovic, V., Ashbaugh, A. R., Santesso, D. L., McCabe, R. E., Antony, M. M., & Schmidt, L. A. (2009) · Biological Psychology · doi:10.1016/j.biopsycho.2009.11.010 · Cited by 90
Developmental Trajectories of the Orbitofrontal Cortex and Anhedonia in Middle Childhood and Risk for Substance Use in Adolescence in a Longitudinal Sample of Depressed and Healthy Preschoolers
Luby, J. L., Arpana Agrawal, A., Belden, A. C., Whalen, D. J., Tillman, R., & Barch, D. M. (2018) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2018.17070777 · Cited by 86
Functional neural substrates of self-reported physical anhedonia in non-clinical individuals and in patients with schizophrenia
Harvey, P., Armony, J. L., MALLA, A. K., & Lepage, M. (2010) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2009.12.008 · Cited by 90
Anxiety and depressive symptoms and affective patterns of tobacco withdrawal
Leventhal, A. M., Ameringer, K. J., Osborn, E., Zvolensky, M. J., & Langdon, K. J. (2013) · Drug and Alcohol Dependence · doi:10.1016/j.drugalcdep.2013.06.015 · Cited by 84
Blunted Reward Processing in Remitted Melancholic Depression
Weinberg, A., & Shankman, S. A. (2016) · Clinical Psychological Science · doi:10.1177/2167702616633158 · Cited by 90
Neurobiology of hedonic tone: the relationship between treatment-resistant depression, attention-deficit hyperactivity disorder, and substance abuse
Katzman, M., & Sternat, T. (2016) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s111818 · Cited by 83
Childhood trauma is associated with elevated anhedonia and altered core reward circuitry in major depression patients and controls
Fan, J., Liu, W., Xia, J., Li, S., Gao, F., Zhu, J., Han, Y., Zhou, H., Liao, H., Yi, J., et al. (2020) · Human Brain Mapping · doi:10.1002/hbm.25222 · Cited by 89
Disrupted reward circuits is associated with cognitive deficits and depression severity in major depressive disorder
Gong, L., Yin, Y., He, C., Ye, Q., Bai, F., Yuan, Y., Zhang, H., Lv, L., Zhang, H., Xie, C., et al. (2017) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2016.09.016 · Cited by 82
Nicotine and endogenous opioids: neurochemical and pharmacological evidence
Hadjiconstantinou, M., & Neff, N. H. (2011) · Neuropharmacology · doi:10.1016/j.neuropharm.2010.11.010 · Cited by 81
Reduced Volume of the Nucleus Accumbens in Heroin Addiction
Seifert, C. L., Magon, S., Sprenger, T., Lang, U. E., Huber, C. G., Denier, N., Vogel, M., Schmidt, A., Radue, E.-W., Borgwardt, S., et al. (2015) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-014-0564-y · Cited by 80
Anhedonia correlates with functional connectivity of the nucleus accumbens subregions in patients with major depressive disorder
Liu, R., Wang, Y., Chen, X., Zhang, Z., Xiao, L., & Zhou, Y. (2021) · NeuroImage Clinical · doi:10.1016/j.nicl.2021.102599 · Cited by 84
Early and late onset, first-episode, treatment-naive depression: same clinical symptoms, different regional neural activities
Chen, J., Liu, F., Xun, G., Chen, H., Hu, M., Guo, X., Xiao, C., Wooderson, S. C., Guo, W., & Zhao, J. (2012) · Journal of Affective Disorders · doi:10.1016/j.jad.2012.05.025 · Cited by 80

Authors: Wacker, J., Dillon, D. G., & Pizzagalli, D. A.
Affiliations: Harvard University (US)
Corresponding author: Pizzagalli, Diego A.
ORCID: Wacker, Jan
Dillon, Daniel G.
Pizzagalli, Diego A.
Venue: NeuroImage
Publisher: Elsevier BV
Published: 2009-05-15
Volume: 46
Issue: 1
Pages: 327-337
ISSN: 1053-8119 (ISSN-L)
DOI: 10.1016/j.neuroimage.2009.01.058
PMC: PMC2686061
OpenAlex: W2102857043
Cited by: 405
References: 101
Citations by year: 2026: 8 · 2025: 18 · 2024: 16 · 2023: 20 · 2022: 39 · 2021: 26 · 2020: 23 · 2019: 22 · 2018: 20 · 2017: 20 · 2016: 28 · 2015: 35 · 2014: 29 · 2013: 25 · 2012: 25
FWCI: 12.30
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: NeuroImage (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
Funders: National Institute of Mental Health (R01MH068376, R01 MH68376)
National Center for Complementary and Integrative Health (R21AT002974)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
Keywords: anhedonia, nucleus accumbens, rostral anterior cingulate cortex, reward processing, endophenotypes, depression, schizophrenia, reward systems, individual differences, brain volume
MeSH terms: Adult, Affect, Anxiety, Depression, Electroencephalography, Female, Gyrus Cinguli, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Nucleus Accumbens, Reward, Signal Processing, Computer-Assisted

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The role of the nucleus accumbens and rostral anterior cingulate cortex in anhedonia: Integration of resting EEG, fMRI, and volumetric techniques

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks