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The role of the nucleus accumbens and rostral anterior cingulate cortex in anhedonia: Integration of resting EEG, fMRI, and volumetric techniques
Open accessAbstract
Anhedonia, the reduced propensity to experience pleasure, is a promising endophenotype and vulnerability factor for several psychiatric disorders, including depression and schizophrenia. In the present study, we used resting electroencephalography, functional magnetic resonance imaging, and volumetric analyses to probe putative associations between anhedonia and individual differences in key nodes of the brain's reward system in a non-clinical sample. We found that anhedonia, but not other symptoms of depression or anxiety, was correlated with reduced nucleus accumbens (NAcc) responses to rewards (gains in a monetary incentive delay task), reduced NAcc volume, and increased resting delta current density (i.e., decreased resting activity) in the rostral anterior cingulate cortex (rACC), an area previously implicated in positive subjective experience. In addition, NAcc reward responses were inversely associated with rACC resting delta activity, supporting the hypothesis that delta might be lawfully related to activity within the brain's reward circuit. Taken together, these results help elucidate the neural basis of anhedonia and strengthen the argument for anhedonia as an endophenotype for depression.
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“Hypoactivity of the NAcc has been associated with the anhedonic aspects of depression (Wacker et al., 2009); therefore the NAcc hypoactivity observed in the current study may have contributed to the depressive behaviors in adolescents with ELS by increasing anhedonic states, a notion supported by the self-reported mood ratings in ELS adolescents (low positive affect, high negative affect).”
From Reduced nucleus accumbens reactivity and adolescent depression following early-life stress (2013) · cites this paper as Wacker et al., 2009
In the citing paper
“Hypoactivity of the NAcc has been associated with the anhedonic aspects of depression (Wacker et al., 2009); therefore the NAcc hypoactivity observed in the current study may have contributed to the depressive behaviors in adolescents with ELS by increasing anhedonic states, a notion supported by the self-reported mood ratings in ELS adolescents (low positive affect, high negative affect).”
From Reduced nucleus accumbens reactivity and adolescent depression following early-life stress (2013) · cites this paper as Wacker et al., 2009
In the citing paper
“Reduced mesolimbic activity in MDD has been found during reward anticipation and outcomes in both adults and children [210,219-227] and during reward learning [206].”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [227]
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The Brain's Default Network: Anatomy, Function, and Relevance to Disease
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Reconsidering anhedonia in depression: Lessons from translational neuroscience
Treadway, M. T., & Zald, D. H. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.06.006 · Cited by 1,579
Annual research review: enduring neurobiological effects of childhood abuse and neglect
Teicher, M. H., & Samson, J. A. (2016) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12507 · Cited by 1,473
McLaughlin, K. A., Sheridan, M. A., & Lambert, H. K. (2014) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2014.10.012 · Cited by 1,389
The neurobiology of anhedonia and other reward-related deficits
Der-Avakian, A., & Markou, A. (2012) · Trends in Neurosciences · doi:10.1016/j.tins.2011.11.005 · Cited by 1,130
Neural circuits underlying the pathophysiology of mood disorders
Price, J. L., & Drevets, W. C. (2012) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.12.011 · Cited by 788
Metadata
- Authors
- Wacker, J., Dillon, D. G., & Pizzagalli, D. A.
- Affiliations
- Harvard University (US)
- Corresponding author
- Pizzagalli, Diego A.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2009-05-15
- Volume
- 46
- Issue
- 1
- Pages
- 327-337
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC2686061
- OpenAlex
- W2102857043
- Cited by
- 405
- References
- 101
- Citations by year
- 2026: 8 · 2025: 18 · 2024: 16 · 2023: 20 · 2022: 39 · 2021: 26 · 2020: 23 · 2019: 22 · 2018: 20 · 2017: 20 · 2016: 28 · 2015: 35 · 2014: 29 · 2013: 25 · 2012: 25
- FWCI
- 12.30
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- National Institute of Mental Health (R01MH068376, R01 MH68376)
- National Center for Complementary and Integrative Health (R21AT002974)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Keywords
- anhedonia, nucleus accumbens, rostral anterior cingulate cortex, reward processing, endophenotypes, depression, schizophrenia, reward systems, individual differences, brain volume
- MeSH terms
- Adult, Affect, Anxiety, Depression, Electroencephalography, Female, Gyrus Cinguli, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Nucleus Accumbens, Reward, Signal Processing, Computer-Assisted
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