Localization of cerebral functional deficits in treatment-naive, first-episode schizophrenia using resting-state fMRI
Abstract
Background Spontaneous low-frequency fluctuations (LFF) in the blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) signal have been shown to reflect cerebral spontaneous neural activity, and the present study attempts to explore the functional changes in the regional brain in patients with schizophrenia using the amplitude of the BOLD signals.Methods A total of 66 treatment-naïve, first-episode schizophrenia (FES) patients and 66 normal age- and sex-matched controls were recruited. Resting-state fMRIs were obtained using a gradient-echo echo-planar imaging sequence. The amplitude of LFF (ALFF) was calculated using REST software. Voxel-based analysis of the ALFF maps between control and patient groups was performed with twos-sample t-tests using SPM2.Results Compared to the controls, the FES group showed significantly decreased ALFF in the medial prefrontal lobe (MPFC) and significant increases in the ALFF in the left and right putamen. Significant positive correlations were observed between ALFF values in the bilateral putamen in both the patient and control groups.Conclusions Alterations of the ALFF in the MPFC and putamen in FES observed in the present study suggest that the functional abnormalities of those areas are at an early stage of the disease.
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Greater regional fluctuations in the patient group were detected only in the bilateral putamen.
“Greater regional fluctuations in the patient group were detected only in the bilateral putamen (64).”
From Elevated functional connectivity along a corticostriatal loop and the mechanism of auditory/verbal hallucinations in patients with schizophrenia (2011) · cites this paper as [64]
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- Authors
- Huang, X.-Q., Lui, S., Deng, W., Chan, R. C. K., Wu, Q.-Z., Jiang, L.-J., Zhang, J.-R., Jia, Z.-Y., Li, X.-L., Li, F., Chen, L., Li, T., & Gong, Q.-Y.
- Affiliations
- West China Hospital of Sichuan University (CN)
- Chinese Academy of Sciences (CN)
- Corresponding author
- Li, Tao
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 49
- Issue
- 4
- Pages
- 2901-2906
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2142565797
- Cited by
- 150
- References
- 82
- Citations by year
- 2025: 1 · 2024: 4 · 2023: 8 · 2022: 10 · 2021: 9 · 2020: 5 · 2019: 11 · 2018: 13 · 2017: 11 · 2016: 8 · 2015: 15 · 2014: 12 · 2013: 11 · 2012: 20
- FWCI
- 5.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Institutional Repository of Institute of Psychology, Chinese Academy of Sciences (Institute of Psychology, Chinese Academy of Sciences) (submittedVersion)
- The HKU Scholars Hub (University of Hong Kong) (submittedVersion)
- Funders
- National Natural Science Foundation of China (30625024, 30530300-2006/R3, 30728017, 30700256)
- National Basic Research Program of China (2007CB512301/2/5)
- National High Technology Program of China (2008AA02Z408)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
- Keywords
- first-episode schizophrenia, amplitude of low-frequency fluctuation, resting-state brain activity, medial prefrontal cortex, putamen, treatment-naive patients, early schizophrenia
- MeSH terms
- Brain, Brain Mapping, Female, Humans, Magnetic Resonance Imaging, Rest, Schizophrenia, Young Adult
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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