Maturation of task-induced brain activation and long range functional connectivity in adolescence revealed by multivariate pattern classification
Open accessAbstract
The present study uses multivariate pattern classification analysis to examine maturation in task-induced brain activation and in functional connectivity during adolescence. The multivariate approach allowed accurate discrimination of adolescent boys of respectively 13, 17 and 21years old based on brain activation during a gonogo task, whereas the univariate statistical analyses showed no or only very few, small age-related clusters. Developmental differences in task activation were spatially distributed throughout the brain, indicating differences in the responsiveness of a wide range of task-related and default mode regions. Moreover, these distributed age-distinctive patterns generalized from a simple gonogo task to a cognitively and motivationally very different gambling task, and vice versa. This suggests that functional brain maturation in adolescence is driven by common processes across cognitive tasks as opposed to task-specific processes. Although we confirmed previous reports of age-related differences in functional connectivity, particularly for long range connections (>60mm), these differences were not specific to brain regions that showed maturation of task-induced responsiveness. Together with the task-independency of brain activation maturation, this result suggests that brain connectivity changes in the course of adolescence affect brain functionality at a basic level. This basic change is manifest in a range of tasks, from the simplest gonogo task to a comple…
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- Authors
- Keulers, E. H. H., Goulas, A., Jolles, J., & Stiers, P.
- Affiliations
- Maastricht University (NL)
- Corresponding author
- Stiers, Peter
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 60
- Issue
- 2
- Pages
- 1250-1265
- ISSN
- 1053-8119 (ISSN-L)
- OpenAlex
- W2116569808
- Cited by
- 16
- References
- 14
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2020: 1 · 2019: 1 · 2018: 3 · 2016: 1 · 2015: 3 · 2014: 2 · 2013: 2
- FWCI
- 1.15
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Research Publications (Maastricht University) (publishedVersion)
- VU Research Portal (publishedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- VU Research Portal (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Keywords
- brain maturation, adolescence, long-range functional connectivity, gambling task, default mode network, age differences, multivariate pattern classification
- MeSH terms
- Adolescent, Age Factors, Brain, Brain Mapping, Humans, Magnetic Resonance Imaging, Male, Nerve Net, Pattern Recognition, Automated, Young Adult
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