The DOI matches its Crossref record; 55 of the 56 references it cites were found in a registry or an index.
Amygdala–prefrontal coupling underlies individual differences in emotion regulation
Open accessAbstract
Despite growing evidence on the neural bases of emotion regulation, little is known about the mechanisms underlying individual differences in cognitive regulation of negative emotion, and few studies have used objective measures to quantify regulatory success. Using a trait-like psychophysiological measure of emotion regulation, corrugator electromyography, we obtained an objective index of the ability to cognitively reappraise negative emotion in 56 healthy men (Session 1), who returned 1.3 years later to perform the same regulation task using fMRI (Session 2). Results indicated that the corrugator measure of regulatory skill predicted amygdala-prefrontal functional connectivity. Individuals with greater ability to down-regulate negative emotion as indexed by corrugator at Session 1 showed not only greater amygdala attenuation but also greater inverse connectivity between the amygdala and several sectors of the prefrontal cortex while down-regulating negative emotion at Session 2. Our results demonstrate that individual differences in emotion regulation are stable over time and underscore the important role of amygdala-prefrontal coupling for successful regulation of negative emotion.
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“deficits in this key voluntary emotion regulation circuit [58,60] may play an important role in impaired regulation of negative emotion in pediatric PTSD.”
From Trauma, PTSD, and the Developing Brain (2017) · cites this paper as [60]
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Citations
Cites
An Integrative Theory of Prefrontal Cortex Function
Miller, E. K., & Cohen, J. D. (2001) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.24.1.167 · Cited by 12,803 · cited 2×
“While the amygdala detects the significance of potentially emotion-eliciting situations and generates biobehavioral adjustments associated with that emotion (Phelps and LeDoux, 2005), the PFC provides top-down control, such as inhibiting proponent responses, maintaining affective goals, and recruiting further resource…”
BackgroundGross, J. J., & John, O. P. (2003) · Journal of Personality and Social Psychology · doi:10.1037/0022-3514.85.2.348 · Cited by 11,929 · cited 2×
“, 2000), and varies widely across individuals (Gross and John, 2003).”
BackgroundAFNI: Software for analysis and visualization of functional magnetic resonance neuroimages
Cox, R. W. (1996) · Computers and Biomedical Research · doi:10.1006/cbmr.1996.0014 · Cited by 10,913
Emotion regulation: affective, cognitive, and social consequences.
Gross, J. J. (2002) · Psychophysiology · doi:10.1017/s0048577201393198 · Cited by 4,890 · cited 2×
“Reappraisal involves reinterpreting the meaning of an emotional event; for example, creating an alternative scenario or adopting a different attitude (Gross, 2002; Ochsner et al., 2004).”
BackgroundMethodGross, J. J. (1998) · Journal of Personality and Social Psychology · doi:10.1037//0022-3514.74.1.224 · Cited by 4,671 · cited 1×
“…and ―enhance‖ were used to instruct participants to decrease and increase their negative emotion, respectively, using cognitive reappraisal strategies, and our instruction should not be confused with the ―suppress‖ instruction used by Gross (1998, 2002) which refers to inhibiting expression.”
MethodThe cognitive control of emotion
OCHSNER, K., & GROSS, J. (2005) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2005.03.010 · Cited by 4,495 · cited 1×
“Among various forms of regulation, cognitive regulation of emotion using reappraisal as a strategy has received much scientific attention (Ochsner and Gross, 2005).”
BackgroundEMOTION REGULATION: A THEME IN SEARCH OF DEFINITION
Thompson, R. A. (1994) · Monographs of the Society for Research in Child Development · doi:10.1111/j.1540-5834.1994.tb01276.x · Cited by 4,227 · cited 2×
“These findings underscore the trait-like quality of individual differences in emotion regulation and suggest that such individual differences may be an important target for understanding normal variation in temperament (Thompson, 1994) and for determining risk for psychopathology (Davidson, 2004; Phillips et al.”
BackgroundContributions of the Amygdala to Emotion Processing: From Animal Models to Human Behavior
Phelps, E. A., & LeDoux, J. E. (2005) · Neuron · doi:10.1016/j.neuron.2005.09.025 · Cited by 3,203 · cited 2×
“While the amygdala detects the significance of potentially emotion-eliciting situations and generates biobehavioral adjustments associated with that emotion (Phelps and LeDoux, 2005), the PFC provides top-down control, such as inhibiting proponent responses, maintaining affective goals, and recruiting further resource…”
BackgroundPsychophysiological and Modulatory Interactions in Neuroimaging
Friston, K. J., Buechel, C., Fink, G. R., Morris, J., Rolls, E., & Dolan, R. J. (1997) · NeuroImage · doi:10.1006/nimg.1997.0291 · Cited by 3,097 · cited 4×
“…determine the extent to which individual differences in down- regulatory ability predicted amygdala-PFC connectivity, cEMG difference scores of suppress – maintain were regressed voxel-wise on the functional connectivity of the amygdala during suppress versus maintain trials (Friston et al., 1997).”
MethodInfluentialInternational Affective Picture System (IAPS) : Technical Manual and Affective Ratings
Lang, P. J. (1995) · Medical Entomology and Zoology · Cited by 2,870
Cited by
Sorted by citations
The neural bases of emotion regulation
Etkin, A., Büchel, C., & Gross, J. J. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn4044 · Cited by 1,244
Gabard-Durnam, L. J., Flannery, J., Goff, B., Gee, D. G., Humphreys, K. L., Telzer, E., Hare, T., & Tottenham, N. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.03.038 · Cited by 372
“, 2012), and the strength of these functional connections has predicted emotional behaviors of healthy adults (Banks et al., 2007; Lee et al., 2012).”
Kral, T. R. A., Schuyler, B. S., Mumford, J. A., Rosenkranz, M. A., Lutz, A., & Davidson, R. J. (2018) · NeuroImage · doi:10.1016/j.neuroimage.2018.07.013 · Cited by 326
“, 2006), possibly through functional coupling with the amygdala (Banks et al., 2007; Lee et al., 2012).”
Self-citationStress and the adolescent brain
Tottenham, N., & Galván, A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.030 · Cited by 324
“This pattern is more typical of healthy adults (e.g., Lee et al., 2012), suggesting an acceleration or temporary enhancement of function during development.”
The prefrontal cortex, pathological anxiety, and anxiety disorders
Kenwood, M. M., Kalin, N. H., & Barbas, H. (2021) · Neuropsychopharmacology · doi:10.1038/s41386-021-01109-z · Cited by 379
Metadata
- Authors
- Lee, H., Heller, A. S., van Reekum, C. M., Nelson, B., & Davidson, R. J.
- Affiliations
- University of Wisconsin–Madison (US)
- University of Illinois Chicago (US)
- Corresponding author
- Davidson, Richard J.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 62
- Issue
- 3
- Pages
- 1575-1581
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC3408571
- OpenAlex
- W2155444575
- Cited by
- 219
- References
- 56
- Citations by year
- 2026: 3 · 2025: 17 · 2024: 9 · 2023: 11 · 2022: 14 · 2021: 23 · 2020: 22 · 2019: 16 · 2018: 20 · 2017: 19 · 2016: 23 · 2015: 13 · 2014: 16 · 2013: 12
- FWCI
- 6.71
- Type
- journal article
- Language
- en
- Open access
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- CentAUR (University of Reading) (acceptedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01-MH43454, P50-MH069315)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- emotion regulation, individual differences, amygdala, prefrontal cortex, cognitive reappraisal, negative emotions, longitudinal stability
- MeSH terms
- Amygdala, Brain Mapping, Electromyography, Emotions, Humans, Individuality, Magnetic Resonance Imaging, Male, Neural Pathways, Prefrontal Cortex, Young Adult
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