Decoding the perception of pain from fMRI using multivariate pattern analysis
Open accessAbstract
Pain is known to comprise sensory, cognitive, and affective aspects. Despite numerous previous fMRI studies, however, it remains open which spatial distribution of activity is sufficient to encode whether a stimulus is perceived as painful or not. In this study, we analyzed fMRI data from a perceptual decision-making task in which participants were exposed to near-threshold laser pulses. Using multivariate analyses on different spatial scales, we investigated the predictive capacity of fMRI data for decoding whether a stimulus had been perceived as painful. Our analysis yielded a rank order of brain regions: during pain anticipation, activity in the periaqueductal gray (PAG) and orbitofrontal cortex (OFC) afforded the most accurate trial-by-trial discrimination between painful and non-painful experiences; whereas during the actual stimulation, primary and secondary somatosensory cortex, anterior insula, dorsolateral and ventrolateral prefrontal cortex, and OFC were most discriminative. The most accurate prediction of pain perception from the stimulation period, however, was enabled by the combined activity in pain regions commonly referred to as the 'pain matrix'. Our results demonstrate that the neural representation of (near-threshold) pain is spatially distributed and can be best described at an intermediate spatial scale. In addition to its utility in establishing structure-function mappings, our approach affords trial-by-trial predictions and thus represents a step towards the goal of establishing an objective neuronal marker of pain perception.
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Activity in the PAG and OFC has often been related to processing of anxiety associated with anticipating nociceptive stimuli.
“The activity in the PAG and the OFC has also been often related to the processing of anxiety associated with anticipating nociceptive stimuli (Brodersen et al., 2012; Fairhurst et al., 2007).”
From Distinct neural representations of placebo and nocebo effects (2015) · cites this paper as Brodersen et al., 2012
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- Authors
- Brodersen, K. H., Wiech, K., Lomakina, E. I., Lin, C.-S., Buhmann, J. M., Bingel, U., Ploner, M., Stephan, K. E., & Tracey, I.
- Affiliations
- University of Zurich (CH)
- John Radcliffe Hospital (GB)
- ETH Zurich (CH)
- Wellcome Centre for Human Neuroimaging (GB)
- Corresponding author
- Brodersen, Kay H.
- Wiech, Katja
- ORCID
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 63
- Issue
- 3
- Pages
- 1162-1170
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC3532598
- OpenAlex
- W2037272682
- Cited by
- 200
- References
- 36
- Citations by year
- 2026: 6 · 2025: 5 · 2024: 3 · 2023: 5 · 2022: 12 · 2021: 13 · 2020: 31 · 2019: 16 · 2018: 19 · 2017: 11 · 2016: 24 · 2015: 18 · 2014: 20 · 2013: 16 · 2012: 1
- FWCI
- 11.80
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- NeuroImage (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion, other-oa)
- Repository for Publications and Research Data (ETH Zurich) (submittedVersion, cc-by)
- Universitätsbibliographie, Universität Duisburg-Essen (submittedVersion)
- mediaTUM (Technical University of Munich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion, other-oa)
- ETH Zürich Research Collection
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Wellcome Trust (FMRIB Centre and IT)
- NIHR Oxford Biomedical Research Centre (KW)
- University Research Priority Program ‘Foundations of Human Social Behaviour’ at the University of Zurich (KHB, KES)
- SystemsX.ch project ‘Neurochoice’ (KHB, KES)
- NCCR ‘Neural Plasticity’ (KES)
- Topics
- Health Sciences › Medicine › Physiology › Pain Mechanisms and Treatments
- Life Sciences › Neuroscience › Cognitive Neuroscience › Pain Management and Placebo Effect
- Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
- Keywords
- pain perception, pain matrix, multivariate pattern analysis, periaqueductal gray, orbitofrontal cortex, anterior insula, somatosensory cortex, prefrontal cortex, pain anticipation
- MeSH terms
- Adult, Brain, Brain Mapping, Female, Humans, Image Interpretation, Computer-Assisted, Magnetic Resonance Imaging, Male, Young Adult, Pain Perception
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