The DOI matches its Crossref record; 58 of the 59 references it cites were found in a registry or an index.
Age-related changes in the structure and function of prefrontal cortex–amygdala circuitry in children and adolescents: A multi-modal imaging approach
Open accessAbstract
The uncinate fasciculus is a major white matter tract that provides a crucial link between areas of the human brain that underlie emotion processing and regulation. Specifically, the uncinate fasciculus is the major direct fiber tract that connects the prefrontal cortex and the amygdala. The aim of the present study was to use a multi-modal imaging approach in order to simultaneously examine the relation between structural connectivity of the uncinate fasciculus and functional activation of the amygdala in a youth sample (children and adolescents). Participants were 9 to 19years old and underwent diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI). Results indicate that greater structural connectivity of the uncinate fasciculus predicts reduced amygdala activation to sad and happy faces. This effect is moderated by age, with younger participants exhibiting a stronger relation. Further, decreased amygdala activation to sad faces predicts lower internalizing symptoms. These results provide important insights into brain structure-function relationships during adolescence, and suggest that greater structural connectivity of the uncinate fasciculus may facilitate regulation of the amygdala, particularly during early adolescence. These findings also have implications for understanding the relation between brain structure, function, and the development of emotion regulation difficulties, such as internalizing symptoms.
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“amygdala reactivity to negative faces and images decreases with age [21,33–36], and is accompanied by greater structural and functional connectivity between the amygdala and mPFC/rACC [25,33,34,36].”
From Trauma, PTSD, and the Developing Brain (2017) · cites this paper as [36]
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“Most studies observe linear decreases in amygdala reactivity to affective stimuli with age [30,31,32]”
From Positive and Negative Emotion Regulation in Adolescence: Links to Anxiety and Depression (2019) · cites this paper as [31]
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SPSS and SAS procedures for estimating indirect effects in simple mediation models
Preacher, K. J., & Hayes, A. F. (2004) · Behavior Research Methods, Instruments, & Computers · doi:10.3758/bf03206553 · Cited by 17,383
Advances in functional and structural MR image analysis and implementation as FSL
Smith, S. M., Jenkinson, M., Woolrich, M. W., Beckmann, C. F., Behrens, T. E. J., Johansen-Berg, H., Bannister, P. R., De Luca, M., Drobnjak, I., Flitney, D. E., et al. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.07.051 · Cited by 13,630
Tract-based spatial statistics: Voxelwise analysis of multi-subject diffusion data
Smith, S. M., Jenkinson, M., Johansen‐Berg, H., Rueckert, D., Nichols, T. E., Mackay, C. E., Watkins, K. E., Ciccarelli, O., Cader, M. Z., Matthews, P. M., et al. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.02.024 · Cited by 6,598
Maldjian, J. A., Laurienti, P. J., Kraft, R., & Burdette, J. H. (2003) · NeuroImage · doi:10.1016/s1053-8119(03)00169-1 · Cited by 5,066
The basis of anisotropic water diffusion in the nervous system—A technical review.
Beaulieu, C. (2002) · NMR in Biomedicine · doi:10.1002/nbm.782 · Cited by 4,628
The NimStim set of facial expressions: Judgments from untrained research participants.
Tottenham, N., Tanaka, J. W., Leon, A. C., McCarry, T., Nurse, M., Hare, T. A., Marcus, D. J., Westerlund, A., Casey, B., & Nelson, C. (2009) · Psychiatry Research · doi:10.1016/j.psychres.2008.05.006 · Cited by 3,454
Etkin, A., & Wager, T. D. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2007.07030504 · Cited by 3,391 · cited 2×
“Altered trajectories of uncinate fasciculus development could be associated with the abnormal patterns of amygdala activation observed in these disorders (Etkin and Wager, 2007; Passamonti et al., 2010; Yang et al., 2010).”
BackgroundPsychophysiological and Modulatory Interactions in Neuroimaging
Friston, K. J., Buechel, C., Fink, G. R., Morris, J., Rolls, E., & Dolan, R. J. (1997) · NeuroImage · doi:10.1006/nimg.1997.0291 · Cited by 3,097
Understanding adolescence as a period of social–affective engagement and goal flexibility
Crone, E. A., & Dahl, R. E. (2012) · Nature Reviews Neuroscience · doi:10.1038/nrn3313 · Cited by 2,507
Hayes, A. F., & Matthes, J. (2009) · Behavior Research Methods · doi:10.3758/brm.41.3.924 · Cited by 2,452
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Positive and Negative Emotion Regulation in Adolescence: Links to Anxiety and Depression
Young, K., Sandman, C., & Craske, M. (2019) · Brain Sciences · doi:10.3390/brainsci9040076 · Cited by 485
Gabard-Durnam, L. J., Flannery, J., Goff, B., Gee, D. G., Humphreys, K. L., Telzer, E., Hare, T., & Tottenham, N. (2014) · NeuroImage · doi:10.1016/j.neuroimage.2014.03.038 · Cited by 372
Gee, D. G., Gabard-Durnam, L., Telzer, E. H., Humphreys, K. L., Goff, B., Shapiro, M., Flannery, J., Lumian, D. S., Fareri, D. S., Caldera, C., et al. (2014) · Psychological Science · doi:10.1177/0956797614550878 · Cited by 363
Mechanisms contributing to prefrontal cortex maturation during adolescence
Caballero, A., Granberg, R., & Tseng, K. Y. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.05.013 · Cited by 357
Stress and the adolescent brain
Tottenham, N., & Galván, A. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.07.030 · Cited by 324
Metadata
- Authors
- Swartz, J. R., Carrasco, M., Wiggins, J. L., Thomason, M. E., & Monk, C. S.
- Affiliations
- University of Michigan (US)
- Wayne State University (US)
- Corresponding author
- Swartz, Johnna R.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 86
- Pages
- 212-220
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC3947283
- OpenAlex
- W2015965964
- Semantic Scholar
- e286e448323e664aa06b75ec057dbde859c9d1fc
- Cited by
- 158
- References
- 59
- Citations by year
- 2026: 5 · 2025: 5 · 2024: 5 · 2023: 9 · 2022: 19 · 2021: 15 · 2020: 10 · 2019: 21 · 2018: 22 · 2017: 12 · 2016: 17 · 2015: 12 · 2014: 6
- FWCI
- 6.37
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- Autism Speaks award
- Michigan Institute for Clinical Health Research (MICHR) Pre-doctoral Fellowship (UL1RR024986)
- National Center for Advancing Translational Sciences of the National Institutes of Health (2UL1TR000433)
- Autism Speaks Fellowship
- NARSAD award
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- uncinate fasciculus, structural connectivity, amygdala activation, emotion regulation, face processing, internalizing problems, age-related development, adolescents, children, white matter tracts, structure-function relationship
- MeSH terms
- Adult, Aging, Amygdala, Brain Mapping, Child, Female, Humans, Male, Nerve Fibers, Myelinated, Nerve Net, Neural Pathways, Sensitivity and Specificity, Reproducibility of Results, Prefrontal Cortex, Young Adult, Diffusion Tensor Imaging, Multimodal Imaging
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