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Sensitive periods of amygdala development: The role of maltreatment in preadolescence
Open accessAbstract
The amygdala is vulnerable to stress-dependent disruptions in neural development. Animal models have shown that stress increases dendritic arborization leading to larger amygdala volumes. Human studies of early stress and amygdala volume, however, remain inconclusive. This study compared amygdala volume in adults with childhood maltreatment to that in healthy controls. Eighteen participants from a longitudinal cohort and 33 cross-sectional controls (17 M/34 F, 25.5±3.1 years) completed a structural magnetic resonance imagining scan and the Maltreatment and Abuse Chronology of Exposure scale. Random forest regression with conditional trees was used to assess relative importance of exposure to adversity at each age on amygdala, thalamic or caudate volume. Severity of exposure to adversity across age accounted for 27% of the variance in right amygdala volume. Peak sensitivity occurred at 10-11 years of age, and importance of exposure at this time was highly significant based on permutation tests (p=0.003). The regression model showed that exposure during this sensitive period resulted in steep dose-response function with maximal response to even modest levels of exposure. Subjects in the highest exposure quartile (MACE-11, range=11-54) had a 9.1% greater right amygdala volume than subjects in the lowest exposure quartile (MACE-11, ≤3.5). No associations emerged between age of exposure and volume of the left amygdala or bilateral caudate or thalamus. Severity of adversity experienced at age 10-11 contributed to larger right but not left amygdala volume in adulthood. Results provide preliminary evidence that the amygdala may have a developmental sensitive period in preadolescence.
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“Thus, right amygdala may be differentially responsive to negative or threatening stimuli (107–109), and alterations in structure (38, 109, 110) of the right amygdala in adulthood have been particularly related to exposure to childhood maltreatment.”
From Disorganized attachment in infancy predicts greater amygdala volume in adulthood (2016) · cites this paper as [38]
In the citing paper
“Interviewed in adulthood, the longitudinal participants reported more severe exposure to maltreatment in childhood than controls and reported lower levels of maternal care on the Parental Bonding Instrument than controls (p = .002).”
From Disorganized attachment in infancy predicts greater amygdala volume in adulthood (2016) · cites this paper as [38]
In the citing paper
“Severity of childhood maltreatment was significantly related to right hemisphere volumes but not to left volumes, with severity of maltreatment at 10–11 years of age the most important predictor of right amygdala volume.”
From Disorganized attachment in infancy predicts greater amygdala volume in adulthood (2016) · cites this paper as [38]
In the citing paper
“Both left and right amygdala volumes were larger among longitudinal participants than controls, with least square mean adjusted amygdala volume 3.8% greater among the longitudinal group.”
From Disorganized attachment in infancy predicts greater amygdala volume in adulthood (2016) · cites this paper as [38]
In the citing paper
“Also notably, compared to cross-sectional controls, the same participants studied here exhibited right amygdala enlargement in relation to the severity of maltreatment in middle childhood, with peak effect from maltreatment between 10 and 11 years of age (38), but show left amygdala enlargement here in relation to quality of early care.”
From Disorganized attachment in infancy predicts greater amygdala volume in adulthood (2016) · cites this paper as [38]
In the citing paper
“Interestingly, we have previously discussed possible evidence for sensitive periods during which childhood maltreatment influences regional brain development, indicating a potential causal mechanism.45,46”
From Ventral striatum dysfunction in children and adolescents with reactive attachment disorder: functional MRI study (2015) · cites this paper as [46]
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Cited by
Sorted by citations
The effects of childhood maltreatment on brain structure, function and connectivity
Teicher, M. H., Samson, J. A., Anderson, C. M., & Ohashi, K. (2016) · Nature Reviews Neuroscience · doi:10.1038/nrn.2016.111 · Cited by 1,856
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Teicher, M. H., & Samson, J. A. (2016) · Journal of Child Psychology and Psychiatry · doi:10.1111/jcpp.12507 · Cited by 1,473
“Pechtel et al (2014) provided data from a small (n = 18) group of adult subjects in which quality of attachment was evaluated as infants using the strange intruder paradigm.”
Self-citationParadise lost: the neurobiological and clinical consequences of child abuse and neglect
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“Next to the dose-dependent effect, studies suggest a different impact of type and timing of ACE in terms of neurobiological alterations, mental and somatic consequences (26, 30, 34, 35).”
BackgroundInfluential
Metadata
- Authors
- Pechtel, P., Lyons-Ruth, K., Anderson, C. M., & Teicher, M. H.
- Affiliations
- Harvard University (US)
- Corresponding author
- Pechtel, Pia
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 97
- Pages
- 236-244
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC4258391
- OpenAlex
- W2079348783
- Cited by
- 342
- References
- 78
- Citations by year
- 2026: 14 · 2025: 21 · 2024: 18 · 2023: 43 · 2022: 31 · 2021: 31 · 2020: 35 · 2019: 26 · 2018: 41 · 2017: 26 · 2016: 31 · 2015: 20 · 2014: 4
- FWCI
- 31.87
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- NIH (UL1 RR 025758)
- Frederick Leonhardt Foundation
- Topics
- Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Clinical Psychology › Posttraumatic Stress Disorder Research
- Keywords
- amygdala development, child abuse, sensitive period, late childhood, amygdala volume, adversity exposure, dose-response relationship, thalamus, caudate nucleus, brain structure
- MeSH terms
- Adolescent, Adult, Age Factors, Amygdala, Caudate Nucleus, Child, Child Abuse, Child, Preschool, Cross-Sectional Studies, Female, Hippocampus, Humans, Infant, Longitudinal Studies, Male, Sex Factors, Stress, Psychological, Thalamus, Cohort Studies
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