The DOI matches its Crossref record; 47 of the 49 references it cites were found in a registry or an index.
Partial volume correction in quantitative amyloid imaging
Open accessAbstract
Amyloid imaging is a valuable tool for research and diagnosis in dementing disorders. As positron emission tomography (PET) scanners have limited spatial resolution, measured signals are distorted by partial volume effects. Various techniques have been proposed for correcting partial volume effects, but there is no consensus as to whether these techniques are necessary in amyloid imaging, and, if so, how they should be implemented. We evaluated a two-component partial volume correction technique and a regional spread function technique using both simulated and human Pittsburgh compound B (PiB) PET imaging data. Both correction techniques compensated for partial volume effects and yielded improved detection of subtle changes in PiB retention. However, the regional spread function technique was more accurate in application to simulated data. Because PiB retention estimates depend on the correction technique, standardization is necessary to compare results across groups. Partial volume correction has sometimes been avoided because it increases the sensitivity to inaccuracy in image registration and segmentation. However, our results indicate that appropriate PVC may enhance our ability to detect changes in amyloid deposition.
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“Quality control reviewed post-processing PUP output 42,43 , which includes uptake measure for FreeSurfer-based regions, was included for 1356 PET sessions.”
From OASIS-3: Longitudinal Neuroimaging, Clinical, and Cognitive Dataset for Normal Aging and Alzheimer Disease (2019) · cites this paper as [42]
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“Su et al. 42,49 has demonstrated that the RSF technique was able to improve PET quantification and achieve better sensitivity to longitudinal changes in amyloid burden.”
From OASIS-3: Longitudinal Neuroimaging, Clinical, and Cognitive Dataset for Normal Aging and Alzheimer Disease (2019) · cites this paper as [42]
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“PET imaging analyses were performed using the PET unified pipeline 42,43 (PUP, https://github.com/ysu001/PUP) via XNAT on Dell PowerEdge 1950 servers with Intel Xeon processors running CentOS 5.5 Linux.”
From OASIS-3: Longitudinal Neuroimaging, Clinical, and Cognitive Dataset for Normal Aging and Alzheimer Disease (2019) · cites this paper as [42]
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“Both types of PET data were partial volume corrected using a regional spread function technique27,28.”
From Spatial patterns of neuroimaging biomarker change in individuals from families with autosomal dominant Alzheimer's disease: a longitudinal study (2018) · cites this paper as [27]
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Citations
Cites
Imaging brain amyloid in Alzheimer's disease with Pittsburgh Compound‐B
Klunk, W. E., Engler, H., Nordberg, A., Wang, Y., Blomqvist, G., Holt, D. P., Bergström, M., Savitcheva, I., Huang, G., Estrada, S., et al. (2004) · Annals of Neurology · doi:10.1002/ana.20009 · Cited by 4,496
Self-citationThe Alzheimer’s disease neuroimaging initiative (ADNI): MRI methods
Jack, C. R., Bernstein, M. A., Fox, N. C., Thompson, P., Alexander, G., Harvey, D., Borowski, B., Britson, P. J., L. Whitwell, J., Ward, C., et al. (2008) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.21049 · Cited by 4,347
Self-citationGauthier, S. G., Reisberg, ., Zaudig, M., Petersen, R. C., Ritchie, K. A., Broich, K., Belleville, S., Brodaty, H., Bennett, D. A., Chertkow, H. M., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(06)68542-5 · Cited by 4,094
Clinical and biomarker changes in dominantly inherited Alzheimer's disease
Bateman, R. J., Xiong, C., Benzinger, T. L. S., Fagan, A. M., Goate, A., Fox, N. C., Marcus, D. S., Cairns, N. J., Xie, X., Blazey, T. M., et al. (2012) · New England Journal of Medicine · doi:10.1056/nejmoa1202753 · Cited by 3,814
Self-citationForecasting the global burden of Alzheimer's disease
Brookmeyer, R., Johnson, E., Ziegler‐Graham, K., & Arrighi, H. M. (2007) · Alzheimer's & Dementia · doi:10.1016/j.jalz.2007.04.381 · Cited by 3,370
Alzheimer Mechanisms and Therapeutic Strategies
Huang, Y., & Mucke, L. (2012) · Cell · doi:10.1016/j.cell.2012.02.040 · Cited by 1,758
Partial-Volume Effect in PET Tumor Imaging
Soret, M., Bacharach, S. L., & Buvat, I. (2007) · Journal of Nuclear Medicine · doi:10.2967/jnumed.106.035774 · Cited by 1,597
Distribution Volume Ratios without Blood Sampling from Graphical Analysis of PET Data
Logan, J., Fowler, J. S., Volkow, N. D., Wang, G., Ding, Y., & Alexoff, D. L. (1996) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-199609000-00008 · Cited by 1,515
Han, X., Jovicich, J., Salat, D., van der Kouwe, A., Quinn, B., Czanner, S., Busa, E., Pacheco, J., Albert, M., Killiany, R., et al. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.02.051 · Cited by 1,508
Logan, J., Fowler, J. S., Volkow, N. D., Wolf, A. P., Dewey, S. L., Schlyer, D. J., MacGregor, R. R., HITZEMANN, R. J., Bendriem, B., Gatley, S. J., et al. (1990) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1990.127 · Cited by 1,481
Alzheimer’s Disease: The Challenge of the Second Century
Holtzman, D. M., Morris, J. C., & Goate, A. M. (2011) · Science Translational Medicine · doi:10.1126/scitranslmed.3002369 · Cited by 1,424
Self-citationA Phase 3 Trial of Semagacestat for Treatment of Alzheimer's Disease
Doody, R. S., Raman, R., Farlow, M., Iwatsubo, T., Vellas, B., Joffe, S., Kieburtz, K., He, F., Sun, X., Thomas, R. G., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1210951 · Cited by 1,224
Frequent amyloid deposition without significant cognitive impairment among the elderly
Aizenstein, H. J., Nebes, R. D., Saxton, J. A., Price, J. C., Mathis, C. A., Tsopelas, N. D., Ziolko, S. K., James, J. A., Snitz, B. E., Houck, P. R., et al. (2008) · Archives of Neurology · doi:10.1001/archneur.65.11.1509 · Cited by 1,059
Self-citation[ 11 C]PIB in a nondemented population: Potential antecedent marker of Alzheimer disease
Mintun, M. A., LaRossa, G. N., Sheline, Y. I., Dence, C. S., Lee, S. Y., Mach, R. H., Klunk, W. E., Mathis, C. A., DeKosky, S. T., & Morris, J. C. (2006) · Neurology · doi:10.1212/01.wnl.0000228230.26044.a4 · Cited by 1,036
Self-citationSynthesis and Evaluation of 11C-Labeled 6-Substituted 2-Arylbenzothiazoles as Amyloid Imaging Agents
Mathis, C. A., Wang, Y., Holt, D. P., Huang, G.-F., Debnath, M. L., & Klunk, W. E. (2003) · Journal of Medicinal Chemistry · doi:10.1021/jm030026b · Cited by 976
Self-citationCorrection for partial volume effects in PET: principle and validation.
ROUSSET, O. G., Ma, Y., & Evans, A. C. (1998) · PubMed · Cited by 919
Longitudinal assessment of Aβ and cognition in aging and Alzheimer disease
Villemagne, V. L., Pike, K. E., Chételat, G., Ellis, K. A., Mulligan, R. S., Bourgeat, P., Ackermann, U., Jones, G., Szoeke, C., Salvado, O., et al. (2011) · Annals of Neurology · doi:10.1002/ana.22248 · Cited by 833
Self-citationKinetic Modeling of Amyloid Binding in Humans using PET Imaging and Pittsburgh Compound-B
Price, J. C., Klunk, W. E., Lopresti, B. J., Lu, X., Hoge, J. A., Ziolko, S. K., Holt, D. P., MELTZER, C. C., DeKosky, S. T., & Mathis, C. A. (2005) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/sj.jcbfm.9600146 · Cited by 723
Self-citationWong, D. F., Rosenberg, P. B., Zhou, Y., Kumar, A., Raymont, V., Ravert, H. T., Dannals, R. F., Nandi, A., Brašić, J. R., Ye, W., et al. (2010) · Journal of Nuclear Medicine · doi:10.2967/jnumed.109.069088 · Cited by 684 · cited 1×
“…(Aβ) plaques with tracers such as [11C]PiB (N-methyl-[11C]2-(4-methylaminophenyl)-6-hydroxybenzothiazole) (Klunk et al., 2004), [18F]florbetapir (Wong et al., 2010), [18F]florbetaben (Rowe et al., 2008) and [18F]flutemetamol (Vandenberghe et al., 2010), enables in vivo measurement of fibrillar…”
BackgroundRowe, C. C., Ackerman, U., Browne, W. F., Mulligan, R. S., Pike, K. E., O'Keefe, G. J., Tochon‐Danguy, H., Chan, G., Berlangieri, S. U., Jones, G. R., et al. (2008) · The Lancet Neurology · doi:10.1016/s1474-4422(08)70001-2 · Cited by 680
Vandenberghe, R. R., Laere, K. V., Ivanoiu, A., Salmon, É., Bastin, C., Triau, E., Hasselbalch, S. G., Law, I. G., Andersen, A., Kørner, A., et al. (2010) · Annals of Neurology · doi:10.1002/ana.22068 · Cited by 664
Jovicich, J., Czanner, S., Han, X., Salat, D. H., van der Kouwe, A. J. W., Quinn, B. T., Pacheco, J., Albert, M., Killiany, R., & Blacker, D. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.02.010 · Cited by 557
Lopresti, B. J., Klunk, W. E., Mathis, C. A., Hoge, J. A., Ziolko, S. K., Lu, X., MELTZER, C. C., Schimmel, K., Tsopelas, N. D., DeKosky, S. T., et al. (2005) · PubMed · Cited by 543
Self-citationMorris, J. C., & Price, J. L. (2001) · Journal of Molecular Neuroscience · doi:10.1385/jmn:17:2:101 · Cited by 513
Self-citationUpdate on the Magnetic Resonance Imaging core of the Alzheimer's Disease Neuroimaging Initiative
Jack, C. R., Bernstein, M. A., Borowski, B., Gunter, J. L., Fox, N. C., Thompson, P. M., Schuff, N. W., Krüger, G., Killiany, R., DeCarli, C. S., et al. (2010) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2010.03.004 · Cited by 379
Self-citationThomas, B. A., Erlandsson, K., Marc Modat, A., Thurfjell, L., Vandenberghe, R. R., Sebastien Ourselin, A., & Hutton, B. F. (2011) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-011-1745-9 · Cited by 317
A Registration and Interpolation Procedure for Subvoxel Matching of Serially Acquired MR Images
Hajnal, J. V., Saeed, N., Soar, E. J., Oatridge, A., YOUNG, I. R., & Bydder, G. M. (1995) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199503000-00022 · Cited by 303
Comparative evaluation of MR-based partial-volume correction schemes for PET.
MELTZER, C. C., Kinahan, P. E., Greer, P. J., Nichols, T. E., Comtat, C., Cantwell, M. N., Lin, M., & Price, J. C. (1999) · PubMed · Cited by 254
Self-citationReducing between scanner differences in multi-center PET studies
Joshi, A., Koeppe, R. A., & Fessler, J. A. (2009) · NeuroImage · doi:10.1016/j.neuroimage.2009.01.057 · Cited by 247
Quantitative Analysis of PiB-PET with FreeSurfer ROIs
Su, Y., D'Angelo, G. M., Vlassenko, A. G., Zhou, G., Snyder, A. Z., Marcus, D. S., Blazey, T. M., Christensen, J. J., Vora, S., Morris, J. C., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0073377 · Cited by 246 · cited 5×
“, 2006); and (iii) putamen was chosen as an example of a subcortical region that can have elevated PiB uptake in AD (Su et al., 2013).”
BackgroundMethodInfluentialSelf-citationMorris, J. C., Aisen, P. S. S., Bateman, R. J., Benzinger, T. L. S., Cairns, N. J., Fagan, A. M., Ghetti, B. F., Goate, A., Holtzman, D. M., Klunk, W. E., et al. (2012) · Clinical Investigation · doi:10.4155/cli.12.93 · Cited by 211
Self-citationComparison of 18F-FDG and PiB PET in Cognitive Impairment
Lowe, V. J., Kemp, B. J., Jack, C. R., Senjem, M. L., Weigand, S. D., Shiung, M. S., Smith, G. E., Knopman, D. S., Boeve, B. F., Mullan, B. P., et al. (2009) · Journal of Nuclear Medicine · doi:10.2967/jnumed.108.058529 · Cited by 196
Meltzer, C. C., Zubieta, J.-K., Brandt, J., Tune, L. E., Mayberg, H., & Frost, J. J. (1996) · Neurology · doi:10.1212/wnl.47.2.454 · Cited by 182
Report of the task force on designing clinical trials in early (predementia) AD
Aisen, P. S. S., Andrieu, S., Sampaio, C., Carrillo, M. C., Khachaturian, Z. S., Dubois, B., Feldman, H., Petersen, R. C., Siemers, E., Doody, R. S., et al. (2010) · Neurology · doi:10.1212/wnl.0b013e318207b1b9 · Cited by 173
Frouin, V., Comtat, C., Reilhac, A., & Grégoire, M. (2002) · PubMed · Cited by 148
Registration of [18F]FDG microPET and small-animal MRI
Rowland, D. J., Garbow, J. R., Laforest, R. A., & Snyder, A. Z. (2005) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2005.05.002 · Cited by 109
Self-citationZaidi, H., Ruest, T., Schoenahl, F., & Montandon, M.-L. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2006.05.031 · Cited by 108
ROUSSET, O. G., Collins, D. L., Rahmim, A., & Wong, D. F. (2008) · Journal of Nuclear Medicine · doi:10.2967/jnumed.107.048330 · Cited by 104
Longitudinal Patterns of β-Amyloid Deposition in Nondemented Older Adults
Sojkova, J., Zhou, Y., An, Y., Kraut, M. A., Ferrucci, L., Wong, D. F., & Resnick, S. M. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.77 · Cited by 102
Alzheimer's disease therapeutic research: the path forward
Aisen, P. S. S. (2009) · Alzheimer s Research & Therapy · doi:10.1186/alzrt2 · Cited by 59
Inter-rater reliability of manual and automated region-of-interest delineation for PiB PET
Rosario, B. L., Weissfeld, L. A., Laymon, C. M., Mathis, C. A., Klunk, W. E., Berginc, M., James, J. A., Hoge, J. A., & Price, J. C. (2011) · NeuroImage · doi:10.1016/j.neuroimage.2010.12.070 · Cited by 52
Self-citationCharacterization of extrastriatal D2 in vivo specific binding of [18F](N‐methyl)benperidol using PET
Eisenstein, S. A., Koller, J. M., Piccirillo, M. L., Kim, A., Antenor‐Dorsey, J. A. V., Videen, T. O., Snyder, A. Z., Karimi, M., Moerlein, S. M., BLACK, K. J., et al. (2012) · Synapse · doi:10.1002/syn.21566 · Cited by 43
Self-citationPogam, A. L., Hatt, M., Descourt, P., Boussion, N., Tsoumpas, C., Turkheimer, F., Prunier‐Aesch, C., Baulieu, J., Guilloteau, D., & Visvikis, D. (2011) · Medical Physics · doi:10.1118/1.3608907 · Cited by 40
Markov random field and Gaussian mixture for segmented MRI-based partial volume correction in PET
Bousse, A., Pedemonte, S., Thomas, B. A., Erlandsson, K., Sebastien Ourselin, A., Arridge, S., & Hutton, B. F. (2012) · Physics in Medicine and Biology · doi:10.1088/0031-9155/57/20/6681 · Cited by 35
Kuhn, F. P., Warnock, G., Burger, C., Ledermann, K., Martin-Söelch, C., & Buck, A. (2014) · EJNMMI Research · doi:10.1186/2191-219x-4-7 · Cited by 27
Kim, E., Shidahara, M., Tsoumpas, C., McGinnity, C. J., Kwon, J. S., Howes, O. D., & Turkheimer, F. (2013) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.2013.29 · Cited by 21
Su, Y., & Shoghi, K. I. (2008) · Physics in Medicine and Biology · doi:10.1088/0031-9155/53/21/001 · Cited by 10
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“PUP accounts for these distortion correction technique is implemented using a regional spread function (RSF) based approach 42,48 .”
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Metadata
- Authors
- Su, Y., Blazey, T. M., Snyder, A. Z., Raichle, M. E., Marcus, D. S., Ances, B. M., Bateman, R. J., Cairns, N. J., Aldea, P., Cash, L., Christensen, J. J., Friedrichsen, K., Hornbeck, R. C., Farrar, A. M., Owen, C. J., Mayeux, R., Brickman, A. M., Klunk, W., Price, J. C., Thompson, P. M., Ghetti, B., Saykin, A. J., Sperling, R. A., Johnson, K. A., Schofield, P. R., Buckles, V., Morris, J. C., & Benzinger, T. L. S.
- Affiliations
- Washington University in St. Louis (US)
- Columbia University Irving Medical Center (US)
- University of Pittsburgh (US)
- University of Southern California (US)
- Indiana University School of Medicine (US)
- Indiana University Indianapolis (US)
- Harvard University (US)
- UNSW Sydney (AU)
- Corresponding author
- Su, Yi
- ORCID
- Su, Yi
- Blazey, Tyler M.
- Snyder, Abraham Z.
- Raichle, Marcus E.
- Marcus, Daniel S.
- Ances, Beau M.
- Bateman, Randall J.
- Cairns, Nigel J.
- Friedrichsen, Karl
- Hornbeck, Russ C.
- Mayeux, Richard
- Brickman, Adam M.
- Klunk, William
- Price, Julie C.
- Thompson, Paul M.
- Saykin, Andrew J.
- Sperling, Reisa A.
- Johnson, Keith A.
- Schofield, Peter R.
- Morris, John C.
- Benzinger, Tammie L.S.
- Venue
- NeuroImage
- Publisher
- Elsevier BV
- Published
- 2015-02
- Volume
- 107
- Pages
- 55-64
- ISSN
- 1053-8119 (ISSN-L)
- PMC
- PMC4300252
- OpenAlex
- W1977541817
- Semantic Scholar
- 77ada80d1d7d2ece501b4ca861e835ea5129a4f1
- Cited by
- 247
- References
- 49
- Citations by year
- 2026: 16 · 2025: 21 · 2024: 21 · 2023: 26 · 2022: 34 · 2021: 22 · 2020: 27 · 2019: 14 · 2018: 24 · 2017: 11 · 2016: 22 · 2015: 8
- FWCI
- 10.69
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- NeuroImage (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- IUScholarWorks (Indiana University) (submittedVersion)
- Funders
- Knight Alzheimer's Disease Research Center (P50AG005681, P01AG003991, P01AG026276, U19AG032438, P30NS048056)
- Charles F. and Joanne Knight Alzheimer's Initiative
- David and Betty Farrell Medical Research Fund
- F Simmons
- O Mohan
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Medical Imaging Techniques and Applications
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Keywords
- partial volume correction, amyloid imaging, Pittsburgh compound B, PET, amyloid deposition, image registration, image segmentation, dementing disorders
- MeSH terms
- Algorithms, Alzheimer Disease, Amyloid, Aniline Compounds, Cerebral Cortex, Computer Simulation, Cross-Sectional Studies, Humans, Individuality, Longitudinal Studies, Thiazoles, Reproducibility of Results, Cohort Studies, Amyloid Neuropathies, Radiopharmaceuticals, Positron-Emission Tomography, Benzothiazoles
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