Cited by 513Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

Pathologic Correlates of Nondemented Aging, Mild Cognitive Impairment, and Early-Stage Alzheimer's Disease

Morris, John C., Price, Joseph L.·2001·Journal of Molecular Neuroscience

Abstract

The results of studies from the Washington University Alzheimer Disease (AD) Research Center and those from other centers and investigators regarding the neuropathologic correlates of normal aging and early-stage AD are reviewed. We conclude that widespread amyloid plaques in the neocortex best distinguishes very early stage AD, including "MCI" stage, and preclinical stages, from healthy brain aging. Other AD lesions, including increased formation of neurofibrillary tangles and neuronal degeneration appear to result from the amyloid-initiated pathologic process, although they may have a more immediate effect on expression and severity of dementia. These data provide strong support for anti-amyloid intervention as a preventive therapy for AD. It is now critical to develop methods to detect preclinical AD during life.

Integrity signals

Registry

Crossref · 10.1385/jmn:17:2:101

Cites

116 of 116 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Cites

Flagged first, then by citations

Cited by

Sorted by citations

Authors
Morris, J. C., & Price, J. L.
Affiliations
Washington University in St. Louis (US)
Corresponding author
Morris, John C.
Venue
Journal of Molecular Neuroscience
Published
2001
Volume
17
Issue
2
Pages
101-118
ISSN
0895-8696 (ISSN-L)
OpenAlex
W2065592408
Cited by
513
References
116
Citations by year
2026: 3 · 2025: 2 · 2024: 11 · 2023: 10 · 2022: 18 · 2021: 21 · 2020: 14 · 2019: 15 · 2018: 13 · 2017: 13 · 2016: 25 · 2015: 34 · 2014: 29 · 2013: 22 · 2012: 38
FWCI
10.36
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Molecular Neuroscience (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute on Aging (AG03991, AG 05681, P50AG005681, P01AG003991)
Topics
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords
Alzheimer's disease, mild cognitive impairment, normal brain aging, amyloid plaques, neurofibrillary tangles, neurodegeneration, preclinical Alzheimer's disease, anti-amyloid therapy, dementia, neuropathology
MeSH terms
Aged, Aging, Alzheimer Disease, Cerebral Cortex, Diagnosis, Differential, Humans, Middle Aged, Neurofibrillary Tangles, Disease Progression, Plaque, Amyloid

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review