Cited by 1,059Dementia and Cognitive Impairment ResearchAlzheimer's disease research and treatmentsCancer-related cognitive impairment studies

Frequent amyloid deposition without significant cognitive impairment among the elderly

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Aizenstein, Howard Jay, Nebes, Robert D., Saxton, Judith A., Price, Julie C., Mathis, Chester A., Tsopelas, Nicholas D., Ziolko, Scott K., James, Jeffrey A. +8 more·2008·Archives of Neurology

Abstract

OBJECTIVE: To characterize the prevalence of amyloid deposition in a clinically unimpaired elderly population, as assessed by Pittsburgh Compound B (PiB) positron emission tomography (PET) imaging, and its relationship to cognitive function, measured with a battery of neuropsychological tests. DESIGN: Subjects underwent cognitive testing and PiB PET imaging (15 mCi for 90 minutes with an ECAT HR+ scanner). Logan graphical analysis was applied to estimate regional PiB retention distribution volume, normalized to a cerebellar reference region volume, to yield distribution volume ratios (DVRs). SETTING: University medical center. PARTICIPANTS: From a community-based sample of volunteers, 43 participants aged 65 to 88 years who did not meet diagnostic criteria for Alzheimer disease or mild cognitive impairment were included. MAIN OUTCOME MEASURES: Regional PiB retention and cognitive test performance. RESULTS: Of 43 clinically unimpaired elderly persons imaged, 9 (21%) showed evidence of early amyloid deposition in at least 1 brain area using an objectively determined DVR cutoff. Demographic characteristics did not differ significantly between amyloid-positive and amyloid-negative participants, and neurocognitive performance was not significantly worse among amyloid-positive compared with amyloid-negative participants. CONCLUSIONS: Amyloid deposition can be identified among cognitively normal elderly persons during life, and the prevalence of asymptomatic amyloid deposition may be similar to that of symptomatic amyloid deposition. In this group of participants without clinically significant impairment, amyloid deposition was not associated with worse cognitive function, suggesting that an elderly person with a significant amyloid burden can remain cognitively normal. However, this finding is based on relatively small numbers and needs to be replicated in larger cohorts. Longitudinal follow-up of these subjects will be required to support the potential of PiB imaging to identify preclinical Alzheimer disease, or, alternatively, to show that amyloid deposition is not sufficient to cause Alzheimer disease within some specified period.

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Authors
Aizenstein, H. J., Nebes, R. D., Saxton, J. A., Price, J. C., Mathis, C. A., Tsopelas, N. D., Ziolko, S. K., James, J. A., Snitz, B. E., Houck, P. R., Bi, W., Cohen, A. D., Lopresti, B. J., DeKosky, S. T., Halligan, E. M., & Klunk, W. E.
Affiliations
University of Pittsburgh (US)
Venue
Archives of Neurology
Published
2008-11-10
Volume
65
Issue
11
Pages
1509
ISSN
0003-9942 (ISSN-L)
OpenAlex
W2075348467
Cited by
1,059
References
52
Citations by year
2026: 30 · 2025: 43 · 2024: 41 · 2023: 47 · 2022: 36 · 2021: 55 · 2020: 66 · 2019: 54 · 2018: 67 · 2017: 52 · 2016: 49 · 2015: 74 · 2014: 74 · 2013: 75 · 2012: 88
FWCI
48.00
Type
journal article
Language
en
Open access
Locations
  • Archives of Neurology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • U.S. Department of Energy (DE-FD02-03 ER63590, ER63590, DE-FD02-03)
  • Alzheimer's Association
  • National Institute on Aging (R01AG018402, P01AG025204, RF1AG025516, P50AG005133, R01AG020226, K02AG001039, R37AG025516)
  • National Institute of Mental Health (R01MH070729, K01MH001976)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
  • Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
  • Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cancer-related cognitive impairment studies
Keywords
amyloid deposition, Pittsburgh compound B, amyloid PET, cognitively normal elderly, preclinical Alzheimer's disease, cognitive function, Alzheimer disease pathogenesis
MeSH terms
Aged, Aged, 80 and over, Alleles, Amyloid, Aniline Compounds, Brain, Cognition, Female, Heterozygote, Humans, Male, Neuropsychological Tests, Reference Values, Thiazoles, Positron-Emission Tomography, Apolipoprotein E4

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