Cited by 139Photoacoustic and Ultrasonic ImagingUltrasound Imaging and ElastographyUltrasound and Hyperthermia Applications

4D microvascular imaging based on ultrafast Doppler tomography

Demené, Charlie, Tiran, Elodie, Sieu, Lim-Anna, Bergel, Antoine, Gennisson, Jean Luc, Pernot, Mathieu, Deffieux, Thomas, Cohen, Ivan +1 more·2016·NeuroImage

Abstract

4D ultrasound microvascular imaging was demonstrated by applying ultrafast Doppler tomography (UFD-T) to the imaging of brain hemodynamics in rodents. In vivo real-time imaging of the rat brain was performed using ultrasonic plane wave transmissions at very high frame rates (18,000 frames per second). Such ultrafast frame rates allow for highly sensitive and wide-field-of-view 2D Doppler imaging of blood vessels far beyond conventional ultrasonography. Voxel anisotropy (100 μm × 100 μm × 500 μm) was corrected for by using a tomographic approach, which consisted of ultrafast acquisitions repeated for different imaging plane orientations over multiple cardiac cycles. UFT-D allows for 4D dynamic microvascular imaging of deep-seated vasculature (up to 20 mm) with a very high 4D resolution (respectively 100 μm × 100 μm × 100 μm and 10 ms) and high sensitivity to flow in small vessels (>1 mm/s) for a whole-brain imaging technique without requiring any contrast agent. 4D ultrasound microvascular imaging in vivo could become a valuable tool for the study of brain hemodynamics, such as cerebral flow autoregulation or vascular remodeling after ischemic stroke recovery, and, more generally, tumor vasculature response to therapeutic treatment.

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Crossref · 10.1016/j.neuroimage.2015.11.014

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Authors
Demené, C., Tiran, E., Sieu, L.-A., Bergel, A., Gennisson, J. L., Pernot, M., Deffieux, T., Cohen, I., & Tanter, M.
Affiliations
Centre National de la Recherche Scientifique (FR)
Corresponding author
Demené, Charlie
Venue
NeuroImage
Publisher
Elsevier BV
Published
2016-02
Volume
127
Pages
472-483
ISSN
1053-8119 (ISSN-L)
OpenAlex
W2125434031
Cited by
139
References
44
Citations by year
2026: 6 · 2025: 19 · 2024: 8 · 2023: 14 · 2022: 8 · 2021: 16 · 2020: 17 · 2019: 19 · 2018: 15 · 2017: 10 · 2016: 7
FWCI
5.31
Type
journal article
Language
en
Open access
closed
Locations
  • NeuroImage (publishedVersion)
  • PubMed (publishedVersion)
  • HAL (submittedVersion)
Funders
  • European Research Council (339244-FUSIMAGINE)
  • Agence Nationale de la Recherche (ANR-10-LABX-24 LABEX WIFI)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Photoacoustic and Ultrasonic Imaging
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Ultrasound Imaging and Elastography
  • Physical Sciences › Engineering › Biomedical Engineering › Ultrasound and Hyperthermia Applications
Keywords
microvascular imaging, cerebral hemodynamics, cerebral blood flow, plane wave propagation, whole-brain imaging, tumor vasculature, contrast-free imaging
MeSH terms
Animals, Brain, Image Processing, Computer-Assisted, Tomography, X-Ray Computed, Rats, Sprague-Dawley, Ultrasonography, Doppler, Imaging, Three-Dimensional, Rats, Neuroimaging

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