Cited by 158Photoacoustic and Ultrasonic ImagingOptical Imaging and Spectroscopy TechniquesNeural dynamics and brain function

EEG and functional ultrasound imaging in mobile rats

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Sieu, Lim-Anna, Bergel, Antoine, Tiran, Elodie, Deffieux, Thomas, Pernot, Mathieu, Gennisson, Jean-Luc, Tanter, Mickaël, Cohen, Ivan·2015·Nature Methods

Abstract

We developed an integrated experimental framework that extends the brain exploration capabilities of functional ultrasound imaging to awake and mobile rats. In addition to acquiring hemodynamic data, this method further allows parallel access to electroencephalography (EEG) recordings of neuronal activity. We illustrate this approach with two proofs of concept: a behavioral study on theta rhythm activation in a maze running task and a disease-related study on spontaneous epileptic seizures.

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Crossref · 10.1038/nmeth.3506

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  • Vascular patterns observed during REMS involve the same highly responsive regions in a similar dynamic sequence (sequential activation of dorsal thalamus, dorsal hippocampus, and cortex) as observed during active running on a similar track.

    “Secondly, the vascular patterns observed during REMS involved the same highly responsive regions in a similar dynamic sequence (sequential activation of dorsal thalamus, dorsal hippocampus, and cortex) as observed and described during active running on a similar track27.”

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Authors
Sieu, L.-A., Bergel, A., Tiran, E., Deffieux, T., Pernot, M., Gennisson, J.-L., Tanter, M., & Cohen, I.
Affiliations
Centre National de la Recherche Scientifique (FR)
Corresponding author
Cohen, Ivan
Venue
Nature Methods
Published
2015-08-03
Volume
12
Issue
9
Pages
831-834
ISSN
  • 1548-7091 (ISSN-L)
  • 1548-7105
OpenAlex
W2099165579
Cited by
158
References
22
Citations by year
2026: 9 · 2025: 20 · 2024: 10 · 2023: 19 · 2022: 18 · 2021: 17 · 2020: 19 · 2019: 14 · 2018: 16 · 2017: 9 · 2016: 4 · 2015: 2
FWCI
5.13
Type
journal article
Language
en
Open access
Locations
  • Nature Methods (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
  • HAL (submittedVersion)
Funders
Agence Nationale de la Recherche (ANR-10-IDEX-0001)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Photoacoustic and Ultrasonic Imaging
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Optical Imaging and Spectroscopy Techniques
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
functional ultrasound imaging, EEG, theta oscillations, epileptic seizures, hemodynamic imaging, neuronal activity, multimodal neuroimaging
MeSH terms
Animals, Brain, Brain Mapping, Echoencephalography, Electroencephalography, Equipment Design, Male, Theta Rhythm, Rats, Sprague-Dawley, Monitoring, Ambulatory, Maze Learning, Equipment Failure Analysis, Rats

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