Cited by 110Advanced Neuroimaging Techniques and ApplicationsFunctional Brain Connectivity StudiesAdvanced MRI Techniques and Applications

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

Fusion in diffusion MRI for improved fibre orientation estimation: An application to the 3T and 7T data of the Human Connectome Project

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Abstract

Determining the acquisition parameters in diffusion magnetic resonance imaging (dMRI) is governed by a series of trade-offs. Images of lower resolution have less spatial specificity but higher signal to noise ratio (SNR). At the same time higher angular contrast, important for resolving complex fibre patterns, also yields lower SNR. Considering these trade-offs, the Human Connectome Project (HCP) acquires high quality dMRI data for the same subjects at different field strengths (3T and 7T), which are publically released. Due to differences in the signal behavior and in the underlying scanner hardware, the HCP 3T and 7T data have complementary features in k- and q-space. The 3T dMRI has higher angular contrast and resolution, while the 7T dMRI has higher spatial resolution. Given the availability of these datasets, we explore the idea of fusing them together with the aim of combining their benefits. We extend a previously proposed data-fusion framework and apply it to integrate both datasets from the same subject into a single joint analysis. We use a generative model for performing parametric spherical deconvolution and estimate fibre orientations by simultaneously using data acquired under different protocols. We illustrate unique features from each dataset and how they are retained after fusion. We further show that this allows us to complement benefits and improve brain connectivity analysis compared to analyzing each of the datasets individually.

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Crossref · 10.1016/j.neuroimage.2016.04.014

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Metadata

Authors
Sotiropoulos, S. N., Hernández-Fernández, M., Vu, A. T., Andersson, J. L., Moeller, S., Yacoub, E., Lenglet, C., Ugurbil, K., Behrens, T. E. J., & Jbabdi, S.
Affiliations
  • University of Oxford (GB)
  • University of Minnesota (US)
  • Wellcome Centre for Human Neuroimaging (GB)
Corresponding author
Sotiropoulos, Stamatios N.
Venue
NeuroImage
Publisher
Elsevier BV
Published
2016-07
Volume
134
Pages
396-409
ISSN
1053-8119 (ISSN-L)
OpenAlex
W2328941635
Cited by
110
References
57
Citations by year
2026: 2 · 2025: 14 · 2024: 15 · 2023: 6 · 2022: 13 · 2021: 13 · 2020: 13 · 2019: 8 · 2018: 11 · 2017: 10 · 2016: 4
FWCI
9.55
Type
journal article
Language
en
Open access
Locations
  • NeuroImage (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • Repository@Nottingham (University of Nottingham) (submittedVersion, cc-by)
Funders
  • Human Connectome Project (1U54MH091657-01)
  • NIH (P41 EB015894)
  • UK EPSRC (EP/L023067/1)
  • UK MRC (MR/L009013/1)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced MRI Techniques and Applications
Keywords
diffusion MRI, data fusion, Human Connectome Project, brain connectivity, generative models, high-field MRI
MeSH terms
Adult, Algorithms, Brain, Female, Humans, Image Enhancement, Image Interpretation, Computer-Assisted, Male, Sensitivity and Specificity, Subtraction Technique, Reproducibility of Results, Diffusion Tensor Imaging, Connectome, White Matter

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