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Cited by 151Neural dynamics and brain functionHeart Rate Variability and Autonomic ControlFunctional Brain Connectivity Studies

Phase-amplitude coupling at the organism level: The amplitude of spontaneous alpha rhythm fluctuations varies with the phase of the infra-slow gastric basal rhythm

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Richter, Craig G., Babo-Rebelo, Mariana, Schwartz, Denis, Tallon-Baudry, Catherine·2017·NeuroImage
DOI 10.1016/j.neuroimage.2016.08.043PMC PMC5312779
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Abstract

A fundamental feature of the temporal organization of neural activity is phase-amplitude coupling between brain rhythms at different frequencies, where the amplitude of a higher frequency varies according to the phase of a lower frequency. Here, we show that this rule extends to brain-organ interactions. We measured both the infra-slow (~0.05Hz) rhythm intrinsically generated by the stomach - the gastric basal rhythm - using electrogastrography, and spontaneous brain dynamics with magnetoencephalography during resting-state with eyes open. We found significant phase-amplitude coupling between the infra-slow gastric phase and the amplitude of the cortical alpha rhythm (10-11Hz), with gastric phase accounting for 8% of the variance of alpha rhythm amplitude fluctuations. Gastric-alpha coupling was localized to the right anterior insula, and bilaterally to occipito-parietal regions. Transfer entropy, a measure of directionality of information transfer, indicates that gastric-alpha coupling is due to an ascending influence from the stomach to both the right anterior insula and occipito-parietal regions. Our results show that phase-amplitude coupling so far only observed within the brain extends to brain-viscera interactions. They further reveal that the temporal structure of spontaneous brain activity depends not only on neuron and network properties endogenous to the brain, but also on the slow electrical rhythm generated by the stomach.

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  • In humans, part of the coupling observed corresponds to information flowing from stomach to brain.

    “but in humans part of the coupling observed corresponds information flowing from stomach to brain 183 .”

    From Interoceptive rhythms in the brain (2023) · cites this paper as [183]

  • Interoceptive mechanisms influence adaptive and maladaptive motivational decisions and have implications for preventing and managing clinical disorders.

    “Detailed understanding of these mechanisms is important given their influence on adaptive [16] and maladaptive [51 ] motivational decisions and their implications for preventing and managing clinical disorders [19 ,20 ,21 ,34,41, 42,46,50 ].”

    From Interoception and emotion. (2017) · cites this paper as [16]

    The Results section (‘Directionality of interactions between stomach and brain’) reports information transfer from gastric rhythm to brain activity, but does not address motivational decisions. Searches for adaptive or maladaptive decisions and for prevention or management of clinical disorders found no passage making those claims in our copy. (LLM, conf=0.76)

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Authors
Richter, C. G., Babo-Rebelo, M., Schwartz, D., & Tallon-Baudry, C.
Affiliations
  • Max Planck Society (DE)
  • Inserm (FR)
  • Centre National de la Recherche Scientifique (FR)
Corresponding author
Richter, Craig G.
ORCID
Venue
NeuroImage
Publisher
Elsevier BV
Published
2017-02
Volume
146
Pages
951-958
ISSN
1053-8119 (ISSN-L)
DOI
10.1016/j.neuroimage.2016.08.043
PMC
PMC5312779
OpenAlex
W2517088698
Cited by
151
References
8
Citations by year
2026: 16 · 2025: 15 · 2024: 17 · 2023: 14 · 2022: 24 · 2021: 16 · 2020: 10 · 2019: 15 · 2018: 13 · 2017: 11
FWCI
8.27
Type
journal article
Language
en
Open access
Licence
Locations
  • NeuroImage (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • HAL (submittedVersion, cc-by-nc-nd)
  • UCL Discovery (University College London) (submittedVersion)
  • Max Planck Digital Library (submittedVersion)
  • MPG.PuRe (Max Planck Society) (submittedVersion)
Funders
  • Agence Nationale de la Recherche (ANR-10-IDEX-0001-02 PSL, ANR-BLAN-BSH2-0002-01)
  • European Research Council
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
phase-amplitude coupling, alpha rhythm, electrogastrography, anterior insula, parieto-occipital cortex, transfer entropy, spontaneous brain activity, resting state
MeSH terms
Adult, Alpha Rhythm, Brain, Female, Humans, Male, Neural Pathways, Stomach, Magnetoencephalography, Young Adult

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