Cited by 169Neural dynamics and brain functionFunctional Brain Connectivity StudiesNeuroscience and Neuropharmacology Research

The Phase of Thalamic Alpha Activity Modulates Cortical Gamma-Band Activity: Evidence from Resting-State MEG Recordings

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Roux, Frédéric, Wibral, Michael, Singer, Wolf, Aru, Jaan, Uhlhaas, Peter J.·2013·The Journal of Neuroscience

Abstract

Recent findings have implicated thalamic alpha oscillations in the phasic modulation of cortical activity. However, the precise relationship between thalamic alpha oscillations and neocortical activity remains unclear. Here we show in a large sample of healthy human participants ( n = 45) using spatial filtering techniques and measures of phase amplitude coupling that the amplitude of gamma-band activity in posterior medial parietal cortex is modulated by the phase of thalamic alpha oscillations during eyes-closed resting-state recordings. In addition, our findings show that gamma-band activity in visual cortex was not modulated by thalamic alpha oscillations but coupled to the phase of strong cortical alpha activity. To overcome the limitations of electromagnetic source localization we estimated conduction delays using transfer entropy and found nonspurious information transfer from thalamus to cortex. The present findings provide novel evidence for magneto-encephalography-measured phase coupling between cortical gamma-band activity and thalamic alpha oscillations, which highlight the role of phasic inhibition in the coordination of cortical activity.

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Crossref · 10.1523/jneurosci.5778-12.2013

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  • There is evidence for alpha-gamma cross-frequency coupling in the pulvinar study and others, forging a link between the first two gain-control mechanisms.

    “there is evidence in this study [57] and others [70,71] for alpha–gamma cross-frequency coupling, thus forging a link between the two mechanisms considered so far.”

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  1. Attal Y, Bhattacharjee M, Yelnik J, Cottereau B, Lefe `vre J, Okada Y, Bardinet E, Chupin M, Baillet S (2007) Modeling and detecting deep brain activity with MEG and EEG. Conf Proc IEEE Eng Med Biol Soc 2007:4937-4940. Medline

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Authors
Roux, F., Wibral, M., Singer, W., Aru, J., & Uhlhaas, P. J.
Affiliations
  • Goethe University Frankfurt (DE)
  • Frankfurt Institute for Advanced Studies (DE)
  • Ernst Strüngmann Institute for Neuroscience (DE)
Venue
The Journal of Neuroscience
Published
2013-11-06
Volume
33
Issue
45
Pages
17827-17835
ISSN
  • 0270-6474 (ISSN-L)
  • 1529-2401
OpenAlex
W2030440331
Cited by
169
References
78
Citations by year
2026: 7 · 2025: 6 · 2024: 6 · 2023: 9 · 2022: 10 · 2021: 15 · 2020: 17 · 2019: 14 · 2018: 17 · 2017: 17 · 2016: 17 · 2015: 21 · 2014: 12 · 2013: 1
FWCI
9.32
Type
journal article
Language
en
Open access
Locations
  • Journal of Neuroscience (publishedVersion, cc-by-nc-sa)
  • Europe PMC (PubMed Central) (publishedVersion)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • Max Planck Institute for Plasma Physics (submittedVersion)
  • ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords
gamma oscillations, phase-amplitude coupling, visual cortex, resting-state brain activity, phasic inhibition, information transmission, transfer entropy, conduction delay, spatial filtering
MeSH terms
Adolescent, Adult, Alpha Rhythm, Brain Mapping, Female, Humans, Male, Parietal Lobe, Thalamus, Magnetoencephalography, Brain Waves

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