The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Seizure-Induced Plasticity of h Channels in Entorhinal Cortical Layer III Pyramidal Neurons
Open accessAbstract
Summary The entorhinal cortex (EC) provides the predominant excitatory drive to the hippocampal CA1 and subicular neurons in chronic epilepsy. Discerning the mechanisms underlying signal integration within EC neurons is essential for understanding network excitability alterations involving the hippocampus during epilepsy. Twenty-four hours following a single seizure episode when there were no behavioral or electrographic seizures, we found enhanced spontaneous activity still present in the rat EC in vivo and in vitro. The increased excitability was accompanied by a profound reduction in Ih in EC layer III neurons and a significant decline in HCN1 and HCN2 subunits that encode for h channels. Consequently, dendritic excitability was enhanced, resulting in increased neuronal firing despite hyperpolarized membrane potentials. The loss of Ih and the increased neuronal excitability persisted for 1 week following seizures. Our results suggest that dendritic Ih plays an important role in determining the excitability of EC layer III neurons and their associated neural networks.
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Cited by
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Neurophysiology of HCN channels: From cellular functions to multiple regulations
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Optogenetic and potassium channel gene therapy in a rodent model of focal neocortical epilepsy
Wykes, R. C., Heeroma, J. H., Mantoan, L., Zheng, K., MacDonald, D. C., Deisseroth, K., Hashemi, K. S., Walker, M. C., Schorge, S., & Kullmann, D. M. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3004190 · Cited by 272
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Metadata
- Authors
- Shah, M. M., Anderson, A. E., Leung, V., Lin, X., & Johnston, D.
- Venue
- Neuron
- Publisher
- Elsevier BV
- Published
- 2004-10
- Volume
- 44
- Issue
- 3
- Pages
- 495-508
- ISSN
- 0896-6273 (ISSN-L)
- OpenAlex
- W2068805802
- Cited by
- 288
- References
- 52
- FWCI
- 11.19
- Type
- journal article
- Language
- en
- Open access
- bronze
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