Intraneuronal Aβ Causes the Onset of Early Alzheimer’s Disease-Related Cognitive Deficits in Transgenic Mice

The Mouse Brain in Stereotaxic Coordinates

Paxinos, G. (2001) · Cited by 12,859

Physical basis of cognitive alterations in alzheimer's disease: Synapse loss is the major correlate of cognitive impairment

Terry, R. D., Masliah, E., Salmon, D. P., Butters, N., DeTeresa, R., Hill, R., Hansen, L. A., & Katzman, R. (1991) · Annals of Neurology · doi:10.1002/ana.410300410 · Cited by 4,397

Correlative Memory Deficits, Aβ Elevation, and Amyloid Plaques in Transgenic Mice

Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., & Cole, G. (1996) · Science · doi:10.1126/science.274.5284.99 · Cited by 4,210

Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126

mouse brain in stereotaxic coordinates

Franklin, K. B. J., & Paxinos, G. (1997) · Cited by 3,258

Neurofibrillary tangles but not senile plaques parallel duration and severity of Alzheimer's disease

Arriagada, P. V., Growdon, J. H., Hedley-Whyte, E. T., & Hyman, B. T. (1992) · Neurology · doi:10.1212/wnl.42.3.631 · Cited by 2,668

The role of the amygdala in fear and anxiety

Davis, M. (1992) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.15.030192.002033 · Cited by 2,357

Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease

Morgan, D., Diamond, D. M., Gottschall, P. E., Ugen, K. E., Dickey, C. A., Hardy, J., Duff, K., Jantzen, P. T., DiCarlo, G., Wilcock, D. M., et al. (2000) · Nature · doi:10.1038/35050116 · Cited by 1,506

Aβ peptide immunization reduces behavioural impairment and plaques in a model of Alzheimer's disease

Janus, C., Pearson, J., McLaurin, J., Mathews, P. M., Jiang, Y., Schmidt, S. D., Chishti, M. A., Horne, P., Heslin, D., French, J., et al. (2000) · Nature · doi:10.1038/35050110 · Cited by 1,431

Attention and executive deficits in Alzheimer's disease: A critical review

Perry, R. J. (1999) · Brain · doi:10.1093/brain/122.3.383 · Cited by 1,252

Mitogen-activated protein kinase signaling pathways promote low-density lipoprotein receptor-related protein 1-mediated internalization of beta-amyloid protein in primary cortical neurons

Yang, W., Ma, K., Qian, Y., Zhang, J.-S., Feng, G.-F., Shi, L., Zhang, Z., & Liu, Z. (2015) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2015.04.013 · Cited by 29

Wading pools, fading memories—place navigation in transgenic mouse models of Alzheimer's disease

Tanila, H. (2012) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2012.00011 · Cited by 28

TDP-43: A new player on the AD field?

Youmans, K. L., & Wolozin, B. L. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.05.018 · Cited by 28

Citalopram Ameliorates Impairments in Spatial Memory and Synaptic Plasticity in Female 3xTgAD Mice

Zhang, W., Junhong, G., Niu, X., Jie, W., Zhaojun, W., Meina, W., Yang, W., Zhang, J., & Qi, J. (2017) · BioMed Research International · doi:10.1155/2017/1238687 · Cited by 29

APP transgenic mice: The effect of active and passive immunotherapy in cognitive tasks

Röskam, S., Neff, F., Schwarting, R. K. W., Bacher, M., & Dodel, R. C. (2009) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2009.10.006 · Cited by 29

BACE1 in the retina: a sensitive biomarker for monitoring early pathological changes in Alzheimer′s disease

Wang, H., Huang, J.-F., Li, L., Luo, J., Chen, D., Tong, J., Zeng, L., Cao, Y.-Q., Xiang, J., Luo, X.-G., et al. (2016) · Neural Regeneration Research · doi:10.4103/1673-5374.179057 · Cited by 27

Molecular Lysine Tweezers Counteract Aberrant Protein Aggregation

Hadrović, I., Rebmann, P., Klärner, F., Bitan, G., & Schrader, T. H. (2019) · Frontiers in Chemistry · doi:10.3389/fchem.2019.00657 · Cited by 27

Somatostatin Receptor Subtype-4 Regulates mRNA Expression of Amyloid-Beta Degrading Enzymes and Microglia Mediators of Phagocytosis in Brains of 3xTg-AD Mice

Sandoval, K. E., Umbaugh, D. S., House, A., Crider, A. M., & WITT, K. A. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02890-6 · Cited by 27

Early changes in synaptic and intrinsic properties of dentate gyrus granule cells in a mouse model of Alzheimer's disease neuropathology and atypical effects of the cholinergic antagonist atropine

Alcantara‐Gonzalez, D., Chartampila, E., Criscuolo, C., & Scharfman, H. E. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105274 · Cited by 25

Spatial coding defects of hippocampal neural ensemble calcium activities in the triple-transgenic Alzheimer's disease mouse model

Lin, X., Chen, L., Baglietto‐Vargas, D., Kamalipour, P., Ye, Q., LaFerla, F. M., Nitz, D. A., Holmes, T. C., & Xu, X. (2021) · Neurobiology of Disease · doi:10.1016/j.nbd.2021.105562 · Cited by 27

Parkin prevents cortical atrophy and Aβ-induced alterations of brain metabolism: 13C NMR and magnetic resonance imaging studies in AD models

Algarzae, N. K., Hebron, M. L., Miessau, M., & Moussa, C. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.08.057 · Cited by 29

Spatial learning impairments in PLB1Triple knock-in Alzheimer mice are task-specific and age-dependent

Ryan, D., Koss, D. J., Porcu, E., Woodcock, H., Robinson, L., Platt, B., & Riedel, G. (2013) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-013-1314-4 · Cited by 27

Design, Synthesis, and Structure–Activity Relationship ofN-Arylnaphthylamine Derivatives as Amyloid Aggregation Inhibitors

Santo, R. D., Costi, R., Crucitti, G. C., Pescatori, L., Rosi, F., Scipione, L., Celona, D., Vertechy, M., Ghirardi, O., Piovesan, P., et al. (2012) · Journal of Medicinal Chemistry · doi:10.1021/jm301105m · Cited by 27

AβPP Accumulation and/or Intraneuronal Amyloid-β Accumulation? The 3xTg-AD Mouse Model Revisited

Wirths, O., Dins, A., & Bayer, T. A. (2012) · Journal of Alzheimer s Disease · doi:10.3233/jad-2011-111529 · Cited by 26

Intraneuronal β‐amyloid and its interactions with proteins and subcellular organelles

Penke, B., Tóth, A. M., Földi, I., Szűcs, M., & Janáky, T. (2012) · Electrophoresis · doi:10.1002/elps.201200297 · Cited by 26

Intraneuronally injected amyloid beta inhibits long-term potentiation in rat hippocampal slices

Nomura, I., Takechi, H., & Kato, N. (2012) · Journal of Neurophysiology · doi:10.1152/jn.00589.2011 · Cited by 27

Activity of muscarinic, galanin and cannabinoid receptors in the prodromal and advanced stages in the triple transgenic mice model of Alzheimer’s disease

Manuel, I., Lombardero, L., LaFerla, F. M., Giménez‐Llort, L., & Rodríguez‐Puertas, R. (2016) · Neuroscience · doi:10.1016/j.neuroscience.2016.05.012 · Cited by 26

Glutamate receptor delocalization in postsynaptic membrane and reduced hippocampal synaptic plasticity in the early stage of Alzheimer’s disease

Li, N., Li, Y., Li, L.-J., Zhu, K., Zheng, Y., & Wang, X. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.250625 · Cited by 28

The Relevance of Amyloid β-Calmodulin Complexation in Neurons and Brain Degeneration in Alzheimer’s Disease

Poejo, J., Salazar, J., Mata, A. M., & Gutiérrez‐Merino, C. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094976 · Cited by 28

Microvascular degeneration occurs before plaque onset and progresses with age in 3xTg AD mice

Quintana, D. D., Anantula, Y., Garcia, J. A., Engler-Chiurazzi, E. B., Sarkar, S. N., Corbin, D. R., Brown, C. M., & Simpkins, J. W. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.04.019 · Cited by 27

Modulation of Neurolipid Signaling and Specific Lipid Species in the Triple Transgenic Mouse Model of Alzheimer’s Disease

Román, E. G. D. S., Llorente‐Ovejero, A., Martínez‐Gardeazabal, J., Moreno‐Rodríguez, M., Giménez‐Llort, L., Manuel, I., & Rodríguez‐Puertas, R. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222212256 · Cited by 27

Sex differences in metabolic phenotype and hypothalamic inflammation in the 3xTg-AD mouse model of Alzheimer’s disease

Robison, L. S., Gannon, O. J., Salinero, A. E., Abi‐Ghanem, C., Kelly, R. D., Riccio, D. A., Mansour, F. M., & Zuloaga, K. L. (2023) · Biology of Sex Differences · doi:10.1186/s13293-023-00536-5 · Cited by 26

Evaluation of the amyloid beta-GFP fusion protein as a model of amyloid beta peptides-mediated aggregation: a study of DNAJB6 chaperone

Hussein, R. M., Hashem, R. M., & Rashed, L. A. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00040 · Cited by 27

Function and Redox State of Peritoneal Leukocytes as Preclinical and Prodromic Markers in a Longitudinal Study of Triple-Transgenic Mice for Alzheimer's Disease

Maté, I., Cruces, J., Giménez‐Llort, L., & la Fuente, M. D. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-140861 · Cited by 28

Differential transgene expression patterns in Alzheimer mouse models revealed by novel human amyloid precursor protein‐specific antibodies

Höfling, C., Morawski, M., Zeitschel, U., Zanier, E. R., Moschke, K., Serdaroglu, A., Canneva, F., von Hörsten, S., Simoni, M. G. D., Forloni, G., et al. (2016) · Aging Cell · doi:10.1111/acel.12508 · Cited by 28

Endocannabinoid and Muscarinic Signaling Crosstalk in the 3xTg-AD Mouse Model of Alzheimer’s Disease

Llorente‐Ovejero, A., Manuel, I., Lombardero, L., Giralt, M. T., Ledent, C. A., Giménez‐Llort, L., & Rodríguez‐Puertas, R. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180137 · Cited by 26

Treatment with scFv-h3D6 Prevented Neuronal Loss and Improved Spatial Memory in Young 3xTg-AD Mice by Reducing the Intracellular Amyloid-β Burden

Esquerda-Canals, G., Roda, A. R., Martı́, J., Montoliu‐Gaya, L., Rivera-Hernández, G., & Villegas, S. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190484 · Cited by 26

Phospholipid transfer protein (PLTP) deficiency accelerates memory dysfunction through altering amyloid precursor protein (APP) processing in a mouse model of Alzheimer's disease

Tong, Y., Sun, Y., Tian, X., Zhou, T., Wang, H., Zhang, T., Zhan, R., Zhao, L., Kuerban, B., Li, Z., et al. (2015) · Human Molecular Genetics · doi:10.1093/hmg/ddv262 · Cited by 26

Drug Development in Alzheimer’s Disease: The Contribution of PET and SPECT

Declercq, L., Vandenberghe, R. R., Laere, K. V., Verbruggen, A., & Bormans, G. M. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00088 · Cited by 27

Mithramycin A Alleviates Cognitive Deficits and Reduces Neuropathology in a Transgenic Mouse Model of Alzheimer’s Disease

Wei, C., Zhang, W., Zhou, Q., Zhao, C., Du, Y., Yan, Q., Li, Z., & Miao, J. (2016) · Neurochemical Research · doi:10.1007/s11064-016-1903-3 · Cited by 25

Ubisol-Q10, a Nanomicellar and Water-Dispersible Formulation of Coenzyme-Q10 as a Potential Treatment for Alzheimer’s and Parkinson’s Disease

Wear, D., Vegh, C., Sandhu, J. K., Sikorska, M., Cohen, J., & Pandey, S. (2021) · Antioxidants · doi:10.3390/antiox10050764 · Cited by 16

Curcugreen Treatment Prevented Splenomegaly and Other Peripheral Organ Abnormalities in 3xTg and 5xFAD Mouse Models of Alzheimer’s Disease

Manna, J., Dunbar, G. L., & Maiti, P. (2021) · Antioxidants · doi:10.3390/antiox10060899 · Cited by 26

Intranasal Paclitaxel Alters Alzheimer’s Disease Phenotypic Features in 3xTg-AD Mice

Cross, D. J., Huber, B. R., Silverman, M. A., Cline, M. M., Gill, T. B., Cross, C. G., Cook, D. G., & Minoshima, S. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-210109 · Cited by 25

Untitled work

(2011) · Europe PMC (PubMed Central) · Cited by 25

Inflammation in Alzheimer’s disease

Heneka, M. T. (2006) · Clinical Neuroscience Research · doi:10.1016/j.cnr.2006.09.005 · Cited by 25

Proteomic alterations of brain subcellular organelles caused by low-dose copper exposure: implication for Alzheimer’s disease

Yu, H., Wang, D., Zou, L., Zhang, Z., Xu, H., Zhu, F., Ren, X., Xu, B., Yuan, J., Liu, J., et al. (2018) · Archives of Toxicology · doi:10.1007/s00204-018-2163-6 · Cited by 25

Galanin Protects Against Intracellular Amyloid Toxicity in Human Primary Neurons

Cui, J., Chen, Q., Yue, X., Jiang, X., Gao, G. F., Yu, L., & Zhang, Y. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1246 · Cited by 25

Short-term high fat diet impairs memory, exacerbates the neuroimmune response, and evokes synaptic degradation via a complement-dependent mechanism in a mouse model of Alzheimer’s disease

Mackey-Alfonso, S. E., Butler, M. J., Taylor, A., Williams-Medina, A. R., Muscat, S. M., Fu, H., & Barrientos, R. M. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.07.021 · Cited by 25

Protein Aggregation Diseases: Toxicity of Soluble Prefibrillar Aggregates and Their Clinical Significance

Stefani, M. (2010) · Methods in molecular biology · doi:10.1007/978-1-60761-756-3_2 · Cited by 25

Phosphorylated Aβ peptides in human Down syndrome brain and different Alzheimer’s-like mouse models

Kumar, S., Lemere, C. A., & Walter, J. (2020) · Acta Neuropathologica Communications · doi:10.1186/s40478-020-00959-w · Cited by 24

Animal Models of the Sporadic Form of Alzheimer's Disease: Focus on the Disease and Not Just the Lesions1

Iqbal, K., Bolognin, S., Wang, X., Basurto‐Islas, G., Blanchard, J., & Tung, Y. C. (2013) · Journal of Alzheimer s Disease · doi:10.3233/jad-130827 · Cited by 24

A sensitive colorimetric strategy for monitoring cerebral β-amyloid peptides in AD based on dual-functionalized gold nanoplasmonic particles

Yu, Y., Zhang, L., Sun, X., Li, C., Qiu, Y., Sun, H.-P., Tang, D., Liu, Y., & Yin, X. (2015) · Chemical Communications · doi:10.1039/c5cc01855b · Cited by 24

Increased Tau Phosphorylation and Tau Truncation, and Decreased Synaptophysin Levels in Mutant BRI2/Tau Transgenic Mice

Garringer, H. J., Murrell, J. R., Sammeta, N., Gnezda, A., Ghetti, B. F., & Vidal, R. (2013) · PLoS ONE · doi:10.1371/journal.pone.0056426 · Cited by 24

Effect of chronic and acute low-frequency repetitive transcranial magnetic stimulation on spatial memory in rats.

Li, W., Yang, Y., Ye, Q., Yang, B., & Wang, Z.-R. (2007) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2006.11.002 · Cited by 24

Experimentally induced diabetes worsens neuropathology, but not learning and memory, in middle aged 3xTg mice

Hayashi-Park, E., Ozment, B. N., Griffith, C. M., Zhang, H., Patrylo, P. R., & Rose, G. M. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.05.020 · Cited by 26

Stereological investigation of the CA1 pyramidal cell layer in untreated and lithium-treated 3xTg-AD and wild-type mice

Schaeffer, E. L., Catanozi, S., West, M. J., & Gattaz, W. F. (2016) · Annals of Anatomy - Anatomischer Anzeiger · doi:10.1016/j.aanat.2016.10.002 · Cited by 24

Intraneuronal β-Amyloid Is a Major Risk Factor – Novel Evidence from the APP/PS1KI Mouse Model

Bayer, T. A., Breyhan, H., Duan, K., Rettig, J., & Wirths, O. (2008) · Neurodegenerative Diseases · doi:10.1159/000113684 · Cited by 24

Vaccination Strategies for Alzheimer???s Disease

Woodhouse, A., Dickson, T. C., & Vickers, J. C. (2007) · Drugs & Aging · doi:10.2165/00002512-200724020-00003 · Cited by 24

The Design, Development, and Evaluation of BACE1 Inhibitors for the Treatment of Alzheimer’s Disease

Ghosh, A. K., Cárdenas, E. L., & Osswald, H. L. (2016) · Topics in medicinal chemistry · doi:10.1007/7355_2016_16 · Cited by 23

Discovery of an evodiamine derivative for PI3K/AKT/GSK3β pathway activation and AD pathology improvement in mouse models

Pang, S., Li, S., Cheng, H., Luo, Z., Qi, X., Guan, F., Dong, W., Gao, S., Liu, N., Gao, X., et al. (2023) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2022.1025066 · Cited by 23

Standardized Herbal Formula PM012 Decreases Cognitive Impairment and Promotes Neurogenesis in the 3xTg AD Mouse Model of Alzheimer’s Disease

Ye, M., Chung, H., An, Y. H., Lim, S.-J., Choi, W., Yu, A., Kim, J. S., Kang, M., Cho, S., Shim, I., et al. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9458-x · Cited by 22

Endogenous β-amyloid peptide synthesis modulates cAMP response element-regulated gene expression in PC12 cells

Echeverrı́a, V., Ducatenzeiler, A., Chen, C. H., & Cuello, A. C. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2005.06.057 · Cited by 24

Electrophysiological Characterization of Networks and Single Cells in the Hippocampal Region of a Transgenic Rat Model of Alzheimer’s Disease

Heggland, I., Kvello, P., & Witter, M. P. (2019) · eNeuro · doi:10.1523/eneuro.0448-17.2019 · Cited by 23

RAPGEF2 mediates oligomeric Aβ‐induced synaptic loss and cognitive dysfunction in the 3xTg‐AD mouse model of Alzheimer’s disease

Jang, Y., Jang, H., Kim, G. H., Noh, J., Chang, K., & Lee, K. J. (2020) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12686 · Cited by 24

Omi is a mammalian heat-shock protein that selectively binds and detoxifies oligomeric amyloid-β

Liu, M.-L., Liu, M.-J., Shen, Y.-F., Ryu, H., Kim, H., Klupsch, K., Downward, J., & Hong, S. (2009) · Journal of Cell Science · doi:10.1242/jcs.042226 · Cited by 23

Homing in on Intracellular Aβ?

Golde, T. E., & Janus, C. (2005) · Neuron · doi:10.1016/j.neuron.2005.02.013 · Cited by 23

Diffusion MRI detects early brain microstructure abnormalities in 2-month-old 3×Tg-AD mice

Falangola, M. F., Nie, X., Ward, R., McKinnon, E. T., Dhiman, S., Nietert, P. J., Helpern, J. A., & Jensen, J. H. (2020) · NMR in Biomedicine · doi:10.1002/nbm.4346 · Cited by 22

Aging induces abnormal accumulation of Aβ in extracellular vesicle and/or intraluminal membrane vesicle-rich fractions in nonhuman primate brain

Koinuma, S., Shimozawa, N., Yasutomi, Y., & Kimura, N. (2021) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2021.06.022 · Cited by 22

Limiting RyR2 open time prevents Alzheimer's disease‐related deficits in the 3xTG‐AD mouse model

Liu, Y., Yao, J., Song, Z., Guo, W., Sun, B., Wei, J., Estillore, J. P., Back, T. G., & Chen, S. R. W. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24936 · Cited by 22

Spatial Memory Impairment is Associated with Intraneural Amyloid-β Immunoreactivity and Dysfunctional Arc Expression in the Hippocampal-CA3 Region of a Transgenic Mouse Model of Alzheimer’s Disease

Morin, J., Cerón-Solano, G., Velázquez-Campos, G., Pacheco‐López, G., Bermúdez‐Rattoni, F., & Díaz-Cintra, S. Y. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150975 · Cited by 22

Age-Related Changes of the Neurovascular Unit in the Cerebral Cortex of Alzheimer Disease Mouse Models: A Neuroanatomical and Molecular Study

Giuliani, A., Sivilia, S., Baldassarro, V. A., Gusciglio, M., Lorenzini, L., Sannia, M., Calzà, L., & Giardino, L. (2019) · Journal of Neuropathology & Experimental Neurology · doi:10.1093/jnen/nly125 · Cited by 23

Dopamine and Aβ-Induced Stress Signaling and Decrements in Ca2+ Buffering In Primary Neonatal Hippocampal Cells Are Antagonized by Blueberry Extract

Joseph, J. A., Carey, A. N., Brewer, G. J., Lau, F. C., & Fisher, D. R. (2007) · Journal of Alzheimer s Disease · doi:10.3233/jad-2007-11404 · Cited by 22

Identification of amyloid-beta 1–42 binding protein fragments by screening of a human brain cDNA library

Munguía, M. E., Govezensky, T., Martinez, R., Manoutcharian, K., & Gevorkian, G. (2005) · Neuroscience Letters · doi:10.1016/j.neulet.2005.11.061 · Cited by 22

Alzheimer’s Amyloid-β Sequesters Caspase-3 in Vitro via Its C-Terminal Tail

Chang, Y., Nguyen, H. L., Shih, Y., Yu, H., Li, M. S., & Chen, Y. (2016) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.6b00049 · Cited by 22

Progressive excitability changes in the medial entorhinal cortex in the 3xTg mouse model of Alzheimer’s disease pathology

Chen, L., Christenson Wick, Z., Vetere, L. M., Vaughan, N., Jurkowski, A., Galas, A., Diego, K. S., Philipsberg, P. A., Soler, I., Feng, Y., et al. (2023) · The Journal of Neuroscience · doi:10.1523/jneurosci.1204-23.2023 · Cited by 21

Olfactory dysfunction in the 3xTg-AD model of Alzheimer’s disease

Mitrano, D. A., Houle, S., Pearce, P., Quintanilla, R. M., Lockhart, B. K., Genovese, B. C., Schendzielos, R., Croushore, E. E., Dymond, E. M., Bogenpohl, J. W., et al. (2021) · IBRO Neuroscience Reports · doi:10.1016/j.ibneur.2020.12.004 · Cited by 21

Maternal High Fat Diet Anticipates the AD-like Phenotype in 3xTg-AD Mice by Epigenetic Dysregulation of Aβ Metabolism

Natale, F., Spinelli, M., Rinaudo, M., Cocco, S., Sarrapochiello, I. N., Fusco, S., & Grassi, C. (2023) · Cells · doi:10.3390/cells12020220 · Cited by 21

Normative mice retinal thickness: 16-month longitudinal characterization of wild-type mice and changes in a model of Alzheimer's disease

Batista, A., Guimarães, P., Martins, J., Moreira, P. I., Ambrósio, A. F., Castelo-Branco, M. S., Serranho, P., & Bernardes, R. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2023.1161847 · Cited by 22

Protein restriction slows the development and progression of pathology in a mouse model of Alzheimer’s disease

Babygirija, R., Sonsalla, M. M., Mill, J., James, I., Han, J. H., Green, C. L., Calubag, M. F., Wade, G., Tobon, A., Michael, J., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49589-z · Cited by 22

Therapeutic Approaches of Leptin in Alzheimers Disease

Carro, E. (2009) · Recent Patents on CNS Drug Discovery · doi:10.2174/157488909789104848 · Cited by 21

Endogenous murine tau promotes neurofibrillary tangles in 3xTg-AD mice without affecting cognition

Baglietto‐Vargas, D., Kitazawa, M., Le, E. J., Estrada-Hernandez, T., Rodríguez‐Ortiz, C. J., Medeiros, R., Green, K. N., & LaFerla, F. M. (2013) · Neurobiology of Disease · doi:10.1016/j.nbd.2013.10.019 · Cited by 21

Genetic Mouse Models of Alzheimer′s Disease

Mineur, Y. S., McLoughlin, D. M., Crusio, W. E., & Sluyter, F. (2005) · Neural Plasticity · doi:10.1155/np.2005.299 · Cited by 22

Oral Triphenylmethane Food Dye Analog, Brilliant Blue G, Prevents Neuronal Loss in APPSwDI/NOS2-/- Mouse Model

Irwin, J. A., Erişir, A., & Kwon, I. (2016) · Current Alzheimer Research · doi:10.2174/1567205013666160208142456 · Cited by 21

BBB-Permeable, Neuroprotective, and Neurotrophic Polysaccharide, Midi-GAGR

Makani, V. S., Jang, Y.-G., Christopher, K., Judy, W., Eckstein, J. M., Hensley, K., Chiaia, N. L., Kim, D.-S., & Park, J. C. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149715 · Cited by 21

The p38 mitogen activated protein kinase regulates β-amyloid protein internalization through the α7 nicotinic acetylcholine receptor in mouse brain

Ma, K., Lv, J., Yang, W., Chang, K.-W., Hu, X., Shi, L., Zhai, W.-Y., Zong, H.-F., & Qian, Y. (2017) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2017.11.006 · Cited by 21

A new statistical method to analyze Morris Water Maze data using Dirichlet distribution

Maugard, M., Doux, C., & Bonvento, G. (2019) · F1000Research · doi:10.12688/f1000research.20072.2 · Cited by 21

Splenocytes derived from young WT mice prevent AD progression in APPswe/PSENldE9 transgenic mice

Wang, F., Shen, X., Li, S., Chen, L., Wang, Y., Qin, J., Zhou, G., Peng, Y., Feng, X., Li, R., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4930 · Cited by 21

Coexisting Cholinergic and Parahippocampal Degeneration: A Key to Memory Loss in Dementia and a Challenge for Transgenic Models?

Cassel, J., Mathis, C., Majchrzak, M. J., Moreau, P., & Dalrymple‐Alford, J. C. (2008) · Neurodegenerative Diseases · doi:10.1159/000135615 · Cited by 21

Amyloid β and impairment in multiple memory systems in older transgenic APP TgCRND8 mice

Hanna, A., Horne, P., Yager, D., Eckman, C., Eckman, E., & Janus, C. (2009) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2009.00510.x · Cited by 20

Development, Optimization and Use of Preclinical Behavioral Models to Maximize the Productivity of Drug Discovery for Alzheimer's Disease

Lindner, M. D., McArthur, R. A., Deadwyler, S. A., Hampson, R. E., & Tariot, P. N. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-373861-5.00016-3 · Cited by 20

Exercise and resveratrol increase fracture resistance in the 3xTg-AD mouse model of Alzheimer’s disease

Alkhouli, M. F., Hung, J., Squire, M., Anderson, M., Castro, M. J., Babu, J. R., Al‐Nakkash, L., Broderick, T. L., & Plochocki, J. H. (2019) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-019-2451-6 · Cited by 21

IL-6 Trans-Signaling in the Brain Influences the Metabolic Phenotype of the 3xTg-AD Mouse Model of Alzheimer’s Disease

Escrig, A., Molinero, A., Méndez, B. B. P., Giralt, M., Comes, G., Sanchís, P., Fernández‐Gayol, O., Giménez‐Llort, L., Becker‐Pauly, C., Rose‐John, S., et al. (2020) · Cells · doi:10.3390/cells9071605 · Cited by 21

Frequency modulation of entorhinal cortex neuronal activity drives distinct frequency-dependent states of brain-wide dynamics

Salvan, P., Lazari, A., Vidaurre, D., Mandino, F., Johansen‐Berg, H., & Grandjean, J. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109954 · Cited by 20

Age-Related Oxidative Redox and Metabolic Changes Precede Intraneuronal Amyloid-β Accumulation and Plaque Deposition in a Transgenic Alzheimer’s Disease Mouse Model

Pontrello, C. G., McWhirt, J., Glabe, C. G., & Brewer, G. J. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220824 · Cited by 20

Rational Design and Acoustic Assembly of Human Cerebral Cortex‐Like Microtissues from hiPSC‐Derived Neural Progenitors and Neurons

Wang, J., Qiao, H., Wang, Z., Zhao, W., Chen, T., Li, B., Zhu, L., Chen, S., Gu, L., Wu, Y., et al. (2023) · Advanced Materials · doi:10.1002/adma.202210631 · Cited by 20

Adipose tissue as a therapeutic target for vascular damage in Alzheimer's disease

Bettinetti‐Luque, M., Trujillo‐Estrada, L., García‐Fuentes, E., Andreo‐Lopez, J., Sanchez-Varo, R. M., Garrido‐Sánchez, L., Mediavilla, A. G., López, M. G., García‐Caballero, M., Gutiérrez, A., et al. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16243 · Cited by 21

Development of a brain-penetrant G9a methylase inhibitor to target Alzheimer’s disease-associated proteopathology

Xie, L., Sheehy, R. N., Muneer, A., Xiong, Y., Wrobel, J. A., Zhang, F., Park, K., Velez, J., Liu, J., Luo, Y., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-59128-z · Cited by 20

The combined treatment of amyloid-β1-42-stimulated bone marrow–derived dendritic cells plus splenocytes from young mice prevents the development of Alzheimer's disease in APPswe/PSENldE9 mice

Wang, F., Liu, H., Shen, X., Ao, H., Moore, N., Gao, L., Chen, L., Hu, H., Ma, H., Yang, Z., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.06.029 · Cited by 20

Early active immunization with Aβ 3–10 -KLH vaccine reduces tau phosphorylation in the hippocampus and protects cognition of mice

Cao, Y., Wang, J.-C., Zhu, K., Zhang, H., Wang, G., & Liu, H. (2019) · Neural Regeneration Research · doi:10.4103/1673-5374.266061 · Cited by 20

A new naphthalene derivative with anti-amyloidogenic activity as potential therapeutic agent for Alzheimer's disease

Rivera-Marrero, S., Bencomo-Martínez, A., Salazar, E. O., Sablón-Carrazana, M., García-Pupo, L., Zoppolo, F., Arredondo, F., Dapueto, R., Santi, M. D., Kreimerman, I., et al. (2020) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2020.115700 · Cited by 20

Impact of Caffeine on Alzheimer’s Disease Pathogenesis—Protective or Risk Factor?

Schreiner, T. G., & Popescu, B. O. (2022) · Life · doi:10.3390/life12030330 · Cited by 23

Exogenous β-amyloid peptide interferes with GLUT4 localization in neurons

de Oliveira, L. T., Leon, G., Provance, D. W., Mello, F. G. D., Sorenson, M. M., & Salerno, V. P. (2015) · Brain Research · doi:10.1016/j.brainres.2015.04.026 · Cited by 20

Immunization with Amyloid-β Attenuates Inclusion Body Myositis-Like Myopathology and Motor Impairment in a Transgenic Mouse Model

Kitazawa, M., Vasilevko, V., Cribbs, D. H., & LaFerla, F. M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.1150-09.2009 · Cited by 20

Early and progressive deficit of neuronal activity patterns in a model of local amyloid pathology in mouse prefrontal cortex

Koukouli, F., Rooy, M., & Maskos, U. (2016) · Aging · doi:10.18632/aging.101136 · Cited by 21

Targeting alpha synuclein and amyloid beta by a multifunctional, brain-penetrant dopamine D2/D3 agonist D-520: Potential therapeutic application in Parkinson’s disease with dementia

Yedlapudi, D., Xu, L., Luo, D., Marsh, G. B., Todi, S. V., & Dutta, A. K. (2019) · Scientific Reports · doi:10.1038/s41598-019-55830-3 · Cited by 20

Impairment of spatial memory consolidation in APP751SL mice results in cue-guided response

Blanchard, J., Martel, G., Guillou, J., Noguès, X., & Micheau, J. (2007) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.02.010 · Cited by 19

Mitochondria-sequestered Aβ renders synaptic mitochondria vulnerable in the elderly with a risk of Alzheimer disease

Jia, K., Tian, J., Wang, T., Guo, L., Xuan, Z., Swerdlow, R. H., & Du, H. (2023) · JCI Insight · doi:10.1172/jci.insight.174290 · Cited by 20

Using Drosophila amyloid toxicity models to study Alzheimer's disease

Tsintzas, E., & Niccoli, T. (2024) · Annals of Human Genetics · doi:10.1111/ahg.12554 · Cited by 20

Fecal Microbiota Transplantation ( FMT ) From a Human at Low Risk for Alzheimer's Disease Improves Short‐Term Recognition Memory and Increases Neuroinflammation in a 3xTg AD Mouse Model

Chevalier, C., Tournier, B. B., Marizzoni, M., Park, R., Paquis, A., Ceyzériat, K., Badina, A. M., Lathuilière, A., Saleri, S., Cillis, F. D., et al. (2025) · Genes Brain & Behavior · doi:10.1111/gbb.70012 · Cited by 19

Accumulation and age-related elevation of amyloid-β within basal forebrain cholinergic neurons in the rhesus monkey

Norvin, D., Kım, G., Baker‐Nigh, A., & Geula, C. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.04.011 · Cited by 19

Modeling behavioral and neuronal symptoms of Alzheimer's disease in mice: A role for intraneuronal amyloid

Giménez‐Llort, L., Blázquez, G., Cañete, T., Johansson, B. A., Oddo, S., Tobeña, A., LaFerla, F. M., & Fernández‐Teruel, A. (2006) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2006.07.007 · Cited by 246

Intraneuronal Amyloid Beta Accumulation Disrupts Hippocampal CRTC1-Dependent Gene Expression and Cognitive Function in a Rat Model of Alzheimer Disease

Wilson, E. N., Abela, A. R., Carmo, S. D., Allard, S. T. M., Marks, A. R., Welikovitch, L. A., Ducatenzeiler, A., Chudasama, Y., & Cuello, A. C. (2016) · Cerebral Cortex · doi:10.1093/cercor/bhv332 · Cited by 56

The Role of Presenilins in Aβ-Induced Cell Death in Alzheimer’s Disease

Ankarcrona, M. (2006) · Springer eBooks · doi:10.1007/978-1-84628-440-3_14

Temporal and regional progression of Alzheimer’s disease‐like pathology in 3xTg‐AD mice

Belfiore, R., Rodin, A., Ferreira, E., Velazquez, R., Branca, C., Caccamo, A., & Oddo, S. (2019) · Aging Cell · doi:10.1111/acel.12873 · Cited by 332

Early-onset behavioral and synaptic deficits in a mouse model of Alzheimer's disease

Jacobsen, J. S., Wu, C.-C., Redwine, J. M., Comery, T. A., Arias, R., Bowlby, M., Martone, R., Morrison, J. H., Pangalos, M. N., Reinhart, P. H., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600948103 · Cited by 701